Cyclin-dependent Kinase-5 Is Involved in Neuregulin-dependent Activation of Phosphatidylinositol 3-Kinase and Akt Activity Mediating Neuronal Survival

Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death Machinery

1997 • 5,665 citations

Cellular survival: a play in three Akts

1999 • 4,229 citations

Cell Death During Development of the Nervous System

1991 • 3,033 citations

Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase Bα

1997 • 2,747 citations

Negative Regulation of PKB/Akt-Dependent Cell Survival by the Tumor Suppressor PTEN

1998 • 2,505 citations

Requirement for Phosphatidylinositol-3 Kinase in the Prevention of Apoptosis by Nerve Growth Factor

1995 • 1,400 citations

Multiple essential functions of neuregulin in development

1995 • 1,236 citations

Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor

1995 • 1,108 citations

The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

1997 • 1,075 citations

Neurotoxicity induces cleavage of p35 to p25 by calpain

2000 • 1,031 citations

Identification of Heregulin, a Specific Activator of p185 ^erbB2

1992 • 963 citations

p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5

1994 • 915 citations

Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death.

1996 • 901 citations

Mice Lacking p35, a Neuronal Specific Activator of Cdk5, Display Cortical Lamination Defects, Seizures, and Adult Lethality

1997 • 727 citations

Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity.

1994 • 692 citations

Calcium promotes cell survival through CaM-K kinase activation of the protein-kinase-B pathway

1998 • 612 citations

ARIA, a protein that stimulates acetylcholine receptor synthesis, is a member of the neu ligand family

1993 • 612 citations

Neuronal Cell Death

1998 • 593 citations

A brain-specific activator of cyclin-dependent kinase 5

1994 • 575 citations

Neuroprotection by Brain-derived Neurotrophic Factor Is Mediated by Extracellular Signal-regulated Kinase and Phosphatidylinositol 3-Kinase

1999 • 561 citations

Phosphorylation of DARPP-32 by Cdk5 modulates dopamine signalling in neurons

1999 • 557 citations

Isolation of the NeuHER-2 stimulatory ligand: A 44 kd glycoprotein that induces differentiation of mammary tumor cells

1992 • 534 citations

Glial growth factor restricts mammalian neural crest stem cells to a glial fate

1994 • 496 citations

Neuregulin and ErbB receptor signaling pathways in the nervous system

2001 • 490 citations

Neuregulins and Their Receptors: A Versatile Signaling Module in Organogenesis and Oncogenesis

1997 • 471 citations

Neu differentiation factor is a neuron-glia signal and regulates survival, proliferation, and maturation of rat schwann cell precursors

1995 • 449 citations

Neuregulin-3 (NRG3): A novel neural tissue-enriched protein that binds and activates ErbB4

1997 • 385 citations

Neuregulin and erbB Receptors Play a Critical Role in Neuronal Migration

1997 • 381 citations

p35 and p39 Are Essential for Cyclin-Dependent Kinase 5 Function during Neurodevelopment

2001 • 379 citations

Calpain-dependent Proteolytic Cleavage of the p35 Cyclin-dependent Kinase 5 Activator to p25

2000 • 378 citations

Role of GGF/neuregulin signaling in interactions between migrating neurons and radial glia in the developing cerebral cortex

1997 • 366 citations

Deregulation of Cdk5 in a Mouse Model of ALS

2001 • 336 citations

Fyn and Cdk5 Mediate Semaphorin-3A Signaling, Which Is Involved in Regulation of Dendrite Orientation in Cerebral Cortex

2002 • 331 citations

Gene Expression Induced by Cerebral Ischemia: An Apoptotic Perspective

1997 • 305 citations

Ligands for ErbB-family receptors encoded by a neuregulin-like gene

1997 • 288 citations

Neuronal cdc2-like kinase: a cdc2-related protein kinase with predominantly neuronal expression.

1992 • 275 citations

Mechanism of Protein Kinase B Activation by Cyclic AMP-Dependent Protein Kinase

1999 • 262 citations

Regulation of NMDA receptors by cyclin-dependent kinase-5

2001 • 255 citations

Schwann cell survival mediated by the signaling phospholipid lysophosphatidic acid

1999 • 253 citations

Mitogen-Activated Protein Kinases (Erk1,2) Phosphorylate Lys-Ser-Pro (KSP) Repeats in Neurofilament Proteins NF-H and NF-M

1998 • 231 citations

cdc2-like kinase from rat spinal cord specifically phosphorylates KSPXK motifs in neurofilament proteins: isolation and characterization.

1993 • 207 citations

Activation of RAC-protein kinase by heat shock and hyperosmolarity stress through a pathway independent of phosphatidylinositol 3-kinase.

1996 • 194 citations

Regulation of Exocytosis by Cyclin-dependent Kinase 5 via Phosphorylation of Munc18

1999 • 191 citations

p39 activates cdk5 in neurons, and is associated with the actin cytoskeleton

2000 • 185 citations

Aberrant development of motor axons and neuromuscular synapses in erbB2-deficient mice

2000 • 181 citations

Role of neuregulins in glial cell development

2000 • 175 citations

Neuregulin receptors, erbB3 and erbB4, are localized at neuromuscular synapses.

1995 • 172 citations

Cdk5 is involved in neuregulin-induced AChR expression at the neuromuscular junction

2001 • 171 citations

Biochemical characterization of the protein tyrosine kinase homology domain of the ErbB3 (HER3) receptor protein

1997 • 164 citations

Receptor stimulated accumulation of phosphatidylinositol (3,4,5)-trisphosphate by G-protein mediated pathways in human myeloid derived cells.

1993 • 162 citations

Regulation of Munc-18/Syntaxin 1A Interaction by Cyclin-dependent Kinase 5 in Nerve Endings

1998 • 160 citations

Cdk5 behind the wheel: a role in trafficking and transport?

2002 • 159 citations

Neurofilament protein synthesis and phosphorylation.

2000 • 158 citations

Migration Defects ofcdk5^−/−Neurons in the Developing Cerebellum is Cell Autonomous

1999 • 142 citations

Heregulin Stimulates Mitogenesis and Phosphatidylinositol 3-Kinase in Mouse Fibroblasts Transfected with erbB2/neu and erbB3

1995 • 141 citations

Cyclin-dependent kinase 5 prevents neuronal apoptosis by negative regulation of c-Jun N-terminal kinase 3

2002 • 134 citations

Amphiphysin 1 Binds the Cyclin-dependent Kinase (cdk) 5 Regulatory Subunit p35 and Is Phosphorylated by cdk5 and cdc2

2001 • 129 citations

Synergistic contributions of cyclin-dependant kinase 5/p35 and Reelin/Dab1 to the positioning of cortical neurons in the developing mouse brain

2001 • 126 citations

Neuregulins and neuregulin receptors in neural development

1997 • 120 citations

Regulated coupling of the Neu receptor to phosphatidylinositol 3'-kinase and its release by oncogenic activation.

1992 • 91 citations

T Cell Activation-dependent Association between the p85 Subunit of the Phosphatidylinositol 3-Kinase and Grb2/Phospholipase C-γ1-binding Phosphotyrosyl Protein pp36/38

1995 • 90 citations

Neuronal Cyclin-Dependent Kinase 5 Activity Is Critical for Survival

2001 • 88 citations

p35 nck5a and cyclin-dependent kinase 5 colocalize in Lewy bodies of brains with Parkinson's disease

1997 • 81 citations

Callosal axon guidance defects in p35?/? mice

1999 • 76 citations

Association of cyclin-dependent kinase 5 and its activator p35 with apoptotic cell death

1997 • 61 citations

Cdk5/p25nck5a interaction with synaptic proteins in bovine brain

2000 • 60 citations

Niemann-Pick Disease Type C Yields Possible Clue for Why Cerebellar Neurons Do Not Form Neurofibrillary Tangles

2002 • 58 citations

Reelin Signaling and Cdk5 in the Control of Neuronal Positioning

2002 • 45 citations

Activation of the Phosphatidylinositol 3-Kinase-Akt/Protein Kinase B Signaling Pathway in Arachidonic Acid-stimulated Human Myeloid and Endothelial Cells

2001 • 41 citations

Cdk5 mediates changes in morphology and promotes apoptosis of astrocytoma cells in response to heat shock

2001 • 39 citations

Cloning of the rat ErbB3 cDNA and characterization of the recombinant protein

1995 • 34 citations

p25 protein in neurodegeneration

2001 • 23 citations