Retinoic acid induces cells cultured from oral squamous cell carcinomas to become anti-angiogenic.

Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line.

1988 • 4,008 citations

“Field cancerization” in oral stratified squamous epithelium. Clinical implications of multicentric origin

1953 • 3,421 citations

Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a lewis lung carcinoma

1994 • 3,367 citations

Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro.

1986 • 2,878 citations

Interleukin-8 as a Macrophage-Derived Mediator of Angiogenesis

1992 • 2,130 citations

Control of Angiogenesis in Fibroblasts by p53 Regulation of Thrombospondin-1

1994 • 1,460 citations

Prevention of Second Primary Tumors with Isotretinoin in Squamous-Cell Carcinoma of the Head and Neck

1990 • 1,375 citations

A tumor suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin.

1990 • 1,062 citations

Transforming Growth Factor-α: a More Potent Angiogenic Mediator than Epidermal Growth Factor

1986 • 856 citations

13-cis-Retinoic Acid in the Treatment of Oral Leukoplakia

1986 • 825 citations

Regulation of Vascular Endothelial Growth Factor Expression in Cultured Keratinocytes.

1995 • 764 citations

Tumorigenic keratinocyte lines requiring anchorage and fibroblast support cultured from human squamous cell carcinomas.

1981 • 743 citations

Association between Cigarette Smoking and Mutation of the p53 Gene in Squamous-Cell Carcinoma of the Head and Neck

1995 • 664 citations

Peptides derived from two separate domains of the matrix protein thrombospondin-1 have anti-angiogenic activity

1993 • 574 citations

Retinoids in cancer therapy.

1992 • 505 citations

Transforming growth factor beta 1-induced changes in cell migration, proliferation, and angiogenesis in the chicken chorioallantoic membrane.

1990 • 470 citations

Comparison of Low-Dose Isotretinoin with Beta Carotene to Prevent Oral Carcinogenesis

1993 • 402 citations

Inhibition of interleukin 8 attenuates angiogenesis in bronchogenic carcinoma.

1994 • 373 citations

Biphasic Effect of Transforming Growth Factor-β1 on in Vitro Angiogenesis

1993 • 338 citations

Intratumoral microvessel density and L53 protein: Correlation with metastasis in head‐and‐neck squamous‐cell carcinoma

1993 • 314 citations

Second malignant tumors in head and neck squamous cell carcinoma: The overshadowing threat for patients with early-stage disease

1989 • 282 citations

Discordant p53 gene mutations in primary head and neck cancers and corresponding second primary cancers of the upper aerodigestive tract.

1993 • 241 citations

Inhibition of angiogenesis through modulation of collagen metabolism.

1988 • 240 citations

Expression of mutated p53 occurs in tumor-distant epithelia of head and neck cancer patients: a possible molecular basis for the development of multiple tumors.

1993 • 200 citations

Tumor angiogenesis as a prognostic factor in oral cavity tumors

1994 • 192 citations

Aberrant production of interleukin-8 and thrombospondin-1 by psoriatic keratinocytes mediates angiogenesis.

1994 • 190 citations

Retinoids, retinoid-responsive genes, cell differentiation, and cancer.

1992 • 158 citations

A highly potent antiangiogenic activity of retinoids

1989 • 143 citations

Synergistic effect of retinoids and interferon α on tumor‐induced angiogenesis: Anti‐angiogenic effect on HPV‐harboring tumor‐cell lines

1994 • 123 citations

Interleukin-8 Expression by Head and Neck Squamous Cell Carcinoma

1995 • 99 citations

Activity of isotretinoin against squamous cell cancers and preneoplastic lesions.

1982 • 97 citations

Inhibition of squamous cell carcinoma angiogenesis by direct interaction of retinoic acid with endothelial cells.

1996 • 88 citations

Modulation by retinoic acid (RA) of squamous cell differentiation, cellular RA-binding proteins, and nuclear RA receptors in human head and neck squamous cell carcinoma cell lines.

1994 • 88 citations

Inhibition of tumor cell-induced angiogenesis by retinoids, 1,25-dihydroxyvitamin D3 and their combination

1993 • 87 citations

Retinoid-sensitive cells and cell lines

1990 • 80 citations

A Human Keratinocyte Cell Line Produces Two Autocrine Growth Inhibitors, Transforming Growth Factor-β and Insulin-like Growth Factor Binding Protein-6, in a Calcium- and Cell Density-dependent Manner

1995 • 74 citations

Assay and purification of naturally occurring inhibitor of angiogenesis

1991 • 73 citations

Transforming growth factor β‐1 positively modulates the bioactivity of fibroblast growth factor on corneal endothelial cells

1989 • 73 citations

Retinoids, Interferon α, 1,25-dihydroxyvitamin D3 and their combination inhibit angiogenesis induced by non-HPV-harboring tumor cell lines. RARα mediates the antiangiogenic effect of retinoids

1995 • 71 citations

Escape from transforming growth factor beta control and oncogene cooperation in skin tumor development.

1991 • 67 citations

Angiogenesis Induced by Head and Neck Squamous Cell Carcinoma Xenografts in the Chick Embryo Chorioallantoic Membrane Model

1993 • 62 citations

Beta-fibroblast growth factor expression in human and murine squamous cell carcinomas and its relationship to regional endothelial cell proliferation.

1993 • 60 citations

p53 gene mutations in oropharyngeal carcinomas: A comparison of solitary and multiple primary tumours and lymph‐node metastases

1994 • 56 citations

Enhanced expression of IL‐8 in normal human keratinocytes and human keratinocyte cell line HaCaT in vitro after stimulation with contact sensitizers., tolerogens and irritants

1994 • 55 citations

Modulation of growth and proliferation in squamous cell carcinoma by retinoic acid: A rationale for combination therapy with chemotherapeutic agents

1995 • 53 citations

Retinoid-induced suppression of squamous cell differentiation in human oral squamous cell carcinoma xenografts (line 1483) in athymic nude mice.

1995 • 47 citations

Inhibition of tumor cell growth by retinoids

1990 • 47 citations

Expression of basic fibroblast growth factor in squamous cell carcinoma of the head and neck is associated with degree of histologic differentiation

1995 • 39 citations

Sequential loss of suppressor genes for three specific functions during in vivo carcinogenesis.

1990 • 38 citations

Tumour Progression in experimental oral carcinogenesis is associated with changes in EGF and TGF-β receptor expression and altered responses to these growth factors

1990 • 30 citations

Resistance of human squamous carcinoma cells to transforming growth factor beta 1 is a recessive trait.

1993 • 23 citations

Inhibition of epithelial cell adhesion by retinoic acid. Relationship to reduced extracellular matrix production and alterations in Ca2+ levels.

1991 • 22 citations

Acitretin Decreases Tumor Cell-Induced Angiogenesis

1991 • 20 citations

Vitamin A effect on tumor angiogenesis

1979 • 16 citations