High Mobility Group A2 Potentiates Genotoxic Stress in Part through the Modulation of Basal and DNA Damage–Dependent Phosphatidylinositol 3-Kinase–Related Protein Kinase Activation

DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139

1998 • 5,093 citations

Cellular processing of platinum anticancer drugs

2005 • 3,539 citations

Anthracyclines: Molecular Advances and Pharmacologic Developments in Antitumor Activity and Cardiotoxicity

2004 • 3,483 citations

RNA interference

2002 • 3,369 citations

ATM and related protein kinases: safeguarding genome integrity

2003 • 2,516 citations

Megabase Chromatin Domains Involved in DNA Double-Strand Breaks in Vivo

1999 • 2,380 citations

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

2000 • 2,052 citations

Cell cycle checkpoint signaling through the ATM and ATR kinases

2001 • 1,962 citations

ATM Phosphorylates Histone H2AX in Response to DNA Double-strand Breaks

2001 • 1,861 citations

Activation of the interferon system by short-interfering RNAs

2003 • 1,416 citations

Genomic Instability in Mice Lacking Histone H2AX

2002 • 1,343 citations

Sequence-specific potent induction of IFN-α by short interfering RNA in plasmacytoid dendritic cells through TLR7

2005 • 1,196 citations

Histone H2AX Is Phosphorylated in an ATR-dependent Manner in Response to Replicational Stress

2001 • 1,109 citations

Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine.

1999 • 1,032 citations

Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

2003 • 968 citations

MDC1 is a mediator of the mammalian DNA damage checkpoint

2003 • 862 citations

A Pathway of Double-Strand Break Rejoining Dependent upon ATM, Artemis, and Proteins Locating to γ-H2AX Foci

2004 • 819 citations

Interfaces Between the Detection, Signaling, and Repair of DNA Damage

2002 • 693 citations

Mutation responsible for the mouse pygmy phenotype in the developmentally regulated factor HMGI-C

1995 • 608 citations

53BP1, a Mediator of the DNA Damage Checkpoint

2002 • 559 citations

Absence of p350 Subunit of DNA-Activated Protein Kinase from a Radiosensitive Human Cell Line

1995 • 530 citations

Molecular biology of HMGA proteins: hubs of nuclear function

2001 • 527 citations

Tumor Cell Death Induced by Topoisomerase-Targeting Drugs

2001 • 499 citations

DNA-PK, ATM and ATR as sensors of DNA damage: variations on a theme?

2001 • 494 citations

DNA damage-induced activation of ATM and ATM-dependent signaling pathways

2004 • 472 citations

Characteristics of γ-H2AX foci at DNA double-strand breaks sites

2003 • 442 citations

Defining the Roles of Nucleotide Excision Repair and Recombination in the Repair of DNA Interstrand Cross-Links in Mammalian Cells

2000 • 440 citations

Interferon induction by siRNAs and ssRNAs synthesized by phage polymerase

2004 • 385 citations

5 DNA Breakage and Repair

1998 • 363 citations

HMGI/Y proteins: flexible regulators of transcription and chromatin structure

2001 • 346 citations

Radiosensitization and DNA repair inhibition by the combined use of novel inhibitors of DNA-dependent protein kinase and poly(ADP-ribose) polymerase-1.

2003 • 331 citations

Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response

2000 • 327 citations

Caffeine Abolishes the Mammalian G2/M DNA Damage Checkpoint by Inhibiting Ataxia-Telangiectasia-mutated Kinase Activity

2000 • 278 citations

Targeted Therapies for Cancer 2004

2004 • 266 citations

A novel DNA-dependent protein kinase inhibitor, NU7026, potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia

2004 • 262 citations

In vivo modulation of Hmgic reduces obesity

2000 • 221 citations

ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK

1999 • 221 citations

Role of DNA–PK in the cellular response to DNA double-strand breaks

2004 • 218 citations

Overexpression of the HMGA2 gene in transgenic mice leads to the onset of pituitary adenomas

2002 • 207 citations

Inhibition of HMGI-C Protein Synthesis Suppresses Retrovirally Induced Neoplastic Transformation of Rat Thyroid Cells

1995 • 195 citations

Expression of Mesenchyme-Specific Gene HMGA2 in Squamous Cell Carcinomas of the Oral Cavity

2004 • 190 citations

Collaboration of homologous recombination and nonhomologous end-joining factors for the survival and integrity of mice and cells

2004 • 153 citations

Topoisomerase II and histone deacetylase inhibitors delay the G2/M transition by triggering the p38 MAPK checkpoint pathway

2004 • 151 citations

Caffeine Inhibits Checkpoint Responses without Inhibiting the Ataxia-Telangiectasia-mutated (ATM) and ATM- and Rad3-related (ATR) Protein Kinases

2003 • 147 citations

Cancer pharmacogenomics: current and future applications

2003 • 141 citations

Transcriptional Activation of the Cyclin A Gene by the Architectural Transcription Factor HMGA2

2003 • 137 citations

RNA interference and double-stranded-RNA-activated pathways

2004 • 123 citations

HMGI(Y) and HMGI-C Dysregulation

1999 • 121 citations

Human Immunodeficiency Virus Type 1 Vpr-Mediated G₂ Arrest Requires Rad17 and Hus1 and Induces Nuclear BRCA1 and γ-H2AX Focus Formation

2004 • 115 citations

An increased high-mobility group A2 expression level is associated with malignant phenotype in pancreatic exocrine tissue

2003 • 114 citations

The Cyclin A1-CDK2 Complex Regulates DNA Double-Strand Break Repair

2004 • 113 citations

Expression ofHMGI-C, a member of the high mobility group protein family, in a subset of breast cancers: Relationship to histologic grade

1997 • 109 citations

The expression pattern of theHmgic gene during development

1998 • 105 citations

The High Mobility Group A2 gene is amplified and overexpressed in human prolactinomas.

2002 • 101 citations

ATR Is Not Required for p53 Activation but Synergizes with p53 in the Replication Checkpoint

2002 • 96 citations

HMGA1 protein over-expression is a frequent feature of epithelial ovarian carcinomas

2003 • 90 citations

Expression of high-mobility-group-protein HMGI-C mRNA in the peripheral blood is an independent poor prognostic indicator for survival in metastatic breast cancer

2003 • 74 citations

Genomic structure and expression of the murine Hmgi-c gene

1996 • 68 citations

Oncogenic Raf-1 Induces the Expression of Non-histone Chromosomal Architectural Protein HMGI-C via a p44/p42 Mitogen-activated Protein Kinase-dependent Pathway in Salivary Epithelial Cells

1997 • 40 citations

Defining the Roles of Nucleotide Excision Repair and Recombination in the Repair of DNA Interstrand Cross-Links in Mammalian Cells

2000 • 14 citations

Deleted Work

1955 • 0 citations