Responsiveness of clonal limb bud cell lines to bone morphogenetic protein 2 reveals a sequential relationship between cartilage and bone cell phenotypes

Bone: Formation by Autoinduction

1965 • 5,498 citations

Novel Regulators of Bone Formation: Molecular Clones and Activities

1988 • 3,919 citations

Recombinant human bone morphogenetic protein induces bone formation.

1990 • 1,538 citations

SPECIFIC STAINING OF SULPHATE GROUPS WITH ALCIAN BLUE AT LOW pH

1964 • 917 citations

Identification of transforming growth factor beta family members present in bone-inductive protein purified from bovine bone.

1990 • 837 citations

The Possible Significance of Hexosephosphoric Esters in Ossification

1923 • 802 citations

Recombinant human bone morphogenetic protein-2 stimulates osteoblastic maturation and inhibits myogenic differentiation in vitro.

1991 • 735 citations

Differentiation of muscle, fat, cartilage, and bone from progenitor cells present in a bone-derived clonal cell population: effect of dexamethasone.

1988 • 656 citations

Involvement of Bone Morphogenetic Protein-4 (BMP-4) and Vgr-1 in morphogenesis and neurogenesis in the mouse

1991 • 646 citations

Organogenesis and pattern formation in the mouse: RNA distribution patterns suggest a role for Bone Morphogenetic Protein-2A (BMP-2A)

1990 • 616 citations

Stage-related capacity for limb chondrogenesis in cell culture

1977 • 616 citations

Independent regulation of collagen types by chondrocytes during the loss of differentiated function in culture

1978 • 596 citations

OP-1 cDNA encodes an osteogenic protein in the TGF-beta family.

1990 • 554 citations

Cell Biology and Biochemistry of Endochondral Bone Development

1981 • 487 citations

The mouse short ear skeletal morphogenesis locus is associated with defects in a bone morphogenetic member of the TGFβ superfamily

1992 • 483 citations

Bone morphogenetic proteins and a signalling pathway that controls patterning in the developing chick limb

1994 • 465 citations

Patterns of expression of murine Vgr-1 and BMP-2a RNA suggest that transforming growth factor-beta-like genes coordinately regulate aspects of embryonic development.

1989 • 440 citations

Recombinant human bone morphogenetic protein-2 induces osteoblastic differentiation in W-20-17 stromal cells.

1992 • 395 citations

Osteocalcin. Biochemical considerations and clinical applications

1988 • 328 citations

The Effect of Parathyroid Hormone on the Concentration of Adenosine 3',5'-Monophosphate in Skeletal Tissue in Vitro

1970 • 319 citations

An analysis of the condensation process during chondrogenesis in the embryonic chick hind limb

1975 • 288 citations

Stimulation of the expression of osteogenic and chondrogenic phenotypes in vitro by osteogenin.

1989 • 224 citations

Stimulation of chondrogenesis in limb bud mesoderm cells by recombinant human bone morphogenetic protein 2B (BMP-2B) and modulation by transforming growth factor ?1 and ?2*1

1991 • 205 citations

Hypertrophic chondrocytes undergo further differentiation in culture

1992 • 192 citations

Secretion of the vitamin K-dependent protein of bone by rat osteosarcoma cells. Evidence for an intracellular precursor.

1980 • 190 citations

Recombinant human bone morphogenetic protein-2 induces osteoblastic differentiation in W-20-17 stromal cells

1992 • 190 citations

Gene expression during osteogenic differentiation in mandibular condyles in vitro.

1990 • 177 citations

Bone-Inducing Activity of Mature BMP-2b Produced from a Hybrid BMP-2a/2b Precursor

1991 • 172 citations

Changes in the expression of collagen genes show two stages in chondrocyte differentiation in vitro

1988 • 169 citations

Adhesion molecules in skeletogenesis: II. Neural cell adhesion molecules mediate precartilaginous mesenchymal condensations and enhance chondrogenesis

1993 • 164 citations

Osteocalcin

1988 • 139 citations

Retinoic Acid Induces Rapid Mineralization and Expression of Mineralization-Related Genes in Chondrocytes

1993 • 136 citations

Trans-differentiation of hypertrophic chondrocytes into cells capable of producing a mineralized bone matrix

1992 • 135 citations

Bone morphogenetic protein-2b stimulation of growth and osteogenic phenotypes in rat osteoblast-like cells: Comparison with TGF-β1

1991 • 129 citations

The transient expression of type II collagen at tissue interfaces during mammalian craniofacial development

1991 • 114 citations

Cell proliferation, extracellular matrix mineralization, and ovotransferrin transient expression during in vitro differentiation of chick hypertrophic chondrocytes into osteoblast-like cells

1993 • 112 citations

Continuously growing bipotential and monopotential myogenic, adipogenic, and chondrogenic subclones isolated from the multipotential RCJ 3.1 clonal cell line

1990 • 111 citations

Osteogenin (bone morphogenetic protein-3) stimulates cartilage formation by chick limb bud cells in vitro

1991 • 105 citations

Cartilage proteoglycan core protein gene expression during limb cartilage differentiation

1986 • 96 citations

An established rat cell line expressing chondrocyte properties

1988 • 88 citations

Activin Enhances Chondrogenesis of Limb Bud Cells: Stimulation of Precartilaginous Mesenchymal Condensations and Expression of NCAM

1993 • 86 citations

Limb Development and Regeneration

1993 • 78 citations

A conditioned medium (CM) factor produced by chondrocytes that promotes their own differentiation

1973 • 74 citations

Modulation of NCAM expression by transforming growth factor-beta, serum, and autocrine factors.

1990 • 74 citations

Generation of murine stromal cell lines supporting hematopoietic stem cell proliferation by use of recombinant retrovirus vectors encoding simian virus 40 large T antigen.

1988 • 68 citations

Transdifferentiation of hypertrophic chondrocytes into osteoblasts in murine fetal metatarsal bones, induced by co-cultured cerebrum

1991 • 66 citations

myc and src oncogenes have complementary effects on cell proliferation and expression of specific extracellular matrix components in definitive chondroblasts.

1985 • 64 citations

Electron microscopic observations on the fate of hypertrophic chondrocytes in condylar cartilage of rat mandible.

1988 • 62 citations

The fate of Meckel's cartilage chondrocytes in ocular culture

1988 • 49 citations

Induction of the neural cell adhesion molecule and neuronal aggregation by osteogenic protein 1.

1992 • 47 citations

The development of three manifestations of the short ear gene in the mouse

1942 • 38 citations

Effects of the short ear gene in the mouse on cartilage formation in healing bone fractures

1958 • 36 citations

Establishment of an osseous cell line from fetal rat calvaria using an immunocytolytic method of cell selection: Characterization of the cell line and of derived clones

1990 • 29 citations

Constitutive myc expression impairs hypertrophy and calcification in cartilage

1992 • 27 citations

Generation of Murine Stromal Cell Lines Supporting Hematopoietic Stem Cell Proliferation by Use of Recombinant Retrovirus Vectors Encoding Simian Virus 40 Large T Antigen

1988 • 26 citations

Bone alkaline phosphatase kinetics studied by a new method

1977 • 11 citations

Antisense c‐myc oligonucleotide promotes chondrogenesis and enhances RA responsiveness of mouse limb mesenchymal cells in vitro

1994 • 7 citations