Ascorbate independent differentiation of human chondrocytes in vitro: simultaneous expression of types I and × collagen and matrix mineralization

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Dedifferentiated chondrocytes reexpress the differentiated collagen phenotype when cultured in agarose gels

1982 • 2,259 citations

Relationship between cell shape and type of collagen synthesised as chondrocytes lose their cartilage phenotype in culture

1977 • 1,054 citations

VESICLES ASSOCIATED WITH CALCIFICATION IN THE MATRIX OF EPIPHYSEAL CARTILAGE

1969 • 1,005 citations

Structure and Function of Collagen Types

1987 • 653 citations

Independent regulation of collagen types by chondrocytes during the loss of differentiated function in culture

1978 • 596 citations

Isolation and Characterization of Calcifying Matrix Vesicles from Epiphyseal Cartilage

1970 • 573 citations

Biosynthesis of Procollagen

1978 • 452 citations

Immunohistochemical localization of short chain cartilage collagen (type X) in avian tissues.

1985 • 451 citations

Characterization of the antibody response in mice with type II collagen–induced arthritis, using monoclonal anti–type II collagen antibodies

1986 • 400 citations

Changes in type of collagen synthesized as clones of chick chondrocytes grow and eventually lose division capacity.

1976 • 355 citations

Ascorbic Acid Induces Alkaline Phosphatase, Type X Collagen, and Calcium Deposition in Cultured Chick Chondrocytes

1989 • 243 citations

A Review of the Primary Mechanism of Endochondral Calcification with Special Emphasis on the Role of Cells, Mitochondria and Matrix Vesicles

1982 • 206 citations

A unique low molecular weight collagen secreted by cultured chick embryo chondrocytes.

1982 • 202 citations

Hypertrophic chondrocytes undergo further differentiation in culture

1992 • 192 citations

Changes in the expression of collagen genes show two stages in chondrocyte differentiation in vitro

1988 • 169 citations

Collagen-binding proteins in collagenase-released matrix vesicles from cartilage. Interaction between matrix vesicle proteins and different types of collagen.

1991 • 158 citations

The identification of matrix Gla protein in cartilage.

1988 • 154 citations

Induction and prevention of chondrocyte hypertrophy in culture.

1989 • 151 citations

The role of three genetically distinct collagen types in endochondral ossification and calcification of cartilage

1977 • 149 citations

Collagens of the Chicken Eggshell Membranes

1991 • 143 citations

Type X collagen synthesis during in vitro development of chick embryo tibial chondrocytes.

1986 • 141 citations

Association of an extracellular protein (chondrocalcin) with the calcification of cartilage in endochondral bone formation.

1984 • 138 citations

Gene expression and extracellular matrix ultrastructure of a mineralizing chondrocyte cell culture system.

1991 • 135 citations

In situ hybridization studies on the expression of type X collagen in fetal human cartilage

1991 • 129 citations

The stimulation of collagen secretion by ascorbate as a result of increased proline hydroxylation in chick embryo fibroblasts

1975 • 121 citations

Synthesis of a low molecular weight collagen by chondrocytes from the presumptive calcification region of the embryonic chick sterna: the influence of culture with collagen gels.

1984 • 116 citations

Immunoelectron microscopic studies of type X collagen in endochondral ossification.

1989 • 111 citations

Spatiotemporal pattern of type X collagen gene expression and collagen deposition in embryonic chick vertebrae undergoing endochondral ossification

1991 • 111 citations

Immunochemical and biochemical study of collagen synthesis by chondrocytes in culture

1977 • 111 citations

Induction of Mineral Deposition by Primary Cultures of Chicken Growth Plate Chondrocytes in Ascorbate-containing Media

1989 • 110 citations

Coordinate regulation of collagen and alkaline phosphatase levels in chick embryo chondrocytes.

1985 • 109 citations

Identification and partial characterization of three low-molecular-weight collagenous polypeptides synthesized by chondrocytes cultured within collagen gels in the absence and in the presence of fibronectin

1983 • 109 citations

Collagen synthesis by articular chondrocytes in monolayer culture

1972 • 108 citations

Developmental expression of genes in chick growth cartilage detected byin situ hybridization

1989 • 97 citations

Resting chondrocytes in culture survive without growth factors, but are sensitive to toxic oxygen metabolites.

1990 • 89 citations

Isolation of human type X collagen and immunolocalization in fetal human cartilage

1991 • 88 citations

Elevated extracellular calcium concentrations induce type X collagen synthesis in chondrocyte cultures.

1991 • 87 citations

Changes in osteonectin distribution and levels are associated with mineralization of the chicken tibial growth cartilage

1990 • 85 citations

The human collagen X gene. Complete primary translated sequence and chromosomal localization

1991 • 85 citations

Synthesis of cartilage matrix by mammalian chondrocytes in vitro. III. Effects of ascorbate.

1984 • 81 citations

In vitro morphogenesis of chick embryo hypertrophic cartilage.

1987 • 80 citations

Effects of Ascorbic Acid on Collagen Mrna Levels in Short Term Chondrocyte Cultures

1988 • 74 citations

Endosomes and Golgi vesicles in adsorptive and fluid phase endocytosis.

1984 • 74 citations

Remodelling of collagen types I, II and X and calcification of human fetal cartilage

1992 • 73 citations

ISI Atlas of Science

1983 • 68 citations

Simulation of the initial stage of endochondral ossification: in vitro sequential culture of growth cartilage cells and bone marrow cells.

1981 • 64 citations

Isolation of cDNAs encoding the complete sequence of bovine type X collagen. Evidence for the condensed nature of mammalian type X collagen genes

1991 • 58 citations

Expression of collagen type transcripts in chick embryonic bone detected by in situ cDNA-mRNA hybridization

1989 • 56 citations

Modulation of type X collagen gene expression by calcium β-glycerophosphate and levamisole: implications for a possible role for type X collagen in endochondral bone formation

1990 • 56 citations

Ca²⁺ binding properties of type X collagen

1991 • 54 citations

The synthesis of type X collagen by bovine and human growth-plate chondrocytes

1991 • 46 citations

The low molecular weight collagen synthesized by chick tibial chondrocytes is deposited in the extracellular matrix both in culture and in vivo.

1984 • 44 citations

An ultrastructural and biochemical study of high density primary cultures of embryonic chick chondrocytes

1977 • 44 citations

Calcification of in vitro developed hypertrophic cartilage

1989 • 42 citations

Cytosolic ionized calcium concentration in isolated chondrocytes from each zone of the growth plate

1989 • 39 citations

Cytosolic free calcium concentrations in avian growth plate chondrocytes

1990 • 37 citations

The effect of ascorbic acid on growth and synthesis of matrix components by cultured chick embryo chondrocytes

1977 • 32 citations

Role of calcium in the phenotypic expression of rabbit articular chondrocytes in culture

1976 • 32 citations

In vitro development of hypertrophic chondrocytes starting from selected clones of dedifferentiated cells.

1990 • 27 citations

Matrix Synthesis in High Density Cultures of Bovine Epiphyseal Plate Chondrocytes

1983 • 23 citations

Independent secretion of proteoglycans and collagens in chick chondrocyte cultures during acute ascorbic acid treatment

1990 • 20 citations

Treatment of Chondrocytes with β‐Glycerophosphate Increases Synthesis of Short‐Chain (Type X) Collagen

1985 • 8 citations