A pathway distinct from the mammalian unfolded protein response regulates expression of endoplasmic reticulum chaperones in non-stressed cells

Protein folding in the cell

1992 • 4,138 citations

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 • 3,111 citations

MOLECULAR CHAPERONE FUNCTIONS OF HEAT-SHOCK PROTEINS

1993 • 1,591 citations

Molecular thanatopsis: a discourse on the BCL2 family and cell death

1996 • 1,412 citations

Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus.

1996 • 1,306 citations

Cytokine receptor signalling

1995 • 1,242 citations

JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin

1993 • 1,223 citations

Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase

1993 • 1,197 citations

CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription.

1992 • 1,156 citations

The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells

1989 • 1,097 citations

A Novel Mechanism for Regulating Activity of a Transcription Factor That Controls the Unfolded Protein Response

1996 • 1,017 citations

Posttranslational association of immunoglobulin heavy chain binding protein with nascent heavy chains in nonsecreting and secreting hybridomas.

1986 • 896 citations

Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis.

1991 • 861 citations

A transmembrane protein with a cdc2+CDC28-related kinase activity is required for signaling from the ER to the nucleus

1993 • 814 citations

Signals from the Stressed Endoplasmic Reticulum Induce C/EBP-Homologous Protein (CHOP/GADD153)

1996 • 671 citations

DNA damage-inducible transcripts in mammalian cells.

1988 • 613 citations

Mammalian stress response: induction of the glucose-regulated protein family

1992 • 452 citations

A novel signal transduction pathway from the endoplasmic reticulum to the nucleus is mediated by transcription factor NF-kappa B.

1995 • 402 citations

A 22 bp cis-acting element is necessary and sufficient for the induction of the yeast KAR2 (BiP) gene by unfolded proteins.

1992 • 375 citations

Overexpression of GRP78 mitigates stress induction of glucose regulated proteins and blocks secretion of selective proteins in Chinese hamster ovary cells.

1992 • 348 citations

CHOP (GADD153) and its oncogenic variant, TLS-CHOP, have opposing effects on the induction of G1/S arrest.

1994 • 331 citations

The Promoter Region of the Yeast KAR2 (BiP) Gene Contains a Regulatory Domain that Responds to the Presence of Unfolded Proteins in the Endoplasmic Reticulum

1993 • 328 citations

Activation of Src family kinases by colony stimulating factor-1, and their association with its receptor.

1993 • 238 citations

Membrane biogenesis during B cell differentiation: most endoplasmic reticulum proteins are expressed coordinately.

1990 • 226 citations

Identity of the immunoglobulin heavy-chain-binding protein with the 78,000-dalton glucose-regulated protein and the role of posttranslational modifications in its binding function.

1988 • 211 citations

Regulation of the C/EBP-related gene gadd153 by glucose deprivation.

1993 • 190 citations

Hematopoietic cell phosphatase associates with erythropoietin (Epo) receptor after Epo-induced receptor tyrosine phosphorylation: identification of potential binding sites

1995 • 187 citations

The Unfolded Protein Response Pathway in

1996 • 180 citations

Activation of the gadd153 promoter by genotoxic agents: a rapid and specific response to DNA damage.

1992 • 175 citations

Inactivation of erythropoietin receptor function by point mutations in a region having homology with other cytokine receptors.

1993 • 174 citations

Gadd45 and Gadd153 messenger RNA levels are increased during hypoxia and after exposure of cells to agents which elevate the levels of the glucose-regulated proteins.

1992 • 173 citations

E2F-1:DP-1 Induces p53 and Overrides Survival Factors To Trigger Apoptosis

1995 • 167 citations

Tyrosine kinase oncogenes abrogate interleukin-3 dependence of murine myeloid cells through signaling pathways involving c-myc: conditional regulation of c-myc transcription by temperature-sensitive v-abl.

1989 • 136 citations

Glucose-regulated protein (GRP94 and GRP78) genes share common regulatory domains and are coordinately regulated by common trans-acting factors.

1989 • 130 citations

Calcium ionophore A23187 induces expression of the growth arrest and DNA damage inducible CCAAT/enhancer-binding protein (C/EBP)-related gene, gadd153. Ca2+ increases transcriptional activity and mRNA stability.

1992 • 129 citations

Transduction of Calcium Stress through Interaction of the Human Transcription Factor CBF with the Proximal CCAAT Regulatory Element of the grp78/BiP Promoter

1995 • 97 citations

Effect of UV-irradiation on cell cycle, viability and the expression of p53, gadd153 and gadd45 genes in normal and HPV-immortalized human oral keratinocytes.

1994 • 88 citations

The 48-kDa subunit of the mammalian oligosaccharyltransferase complex is homologous to the essential yeast protein WBP1.

1992 • 88 citations

Induction of GADD153, a CCAAT/enhancer-binding protein (C/EBP)-related gene, during the acute phase response in rats. Evidence for the involvement of C/EBPs in regulating its expression.

1994 • 85 citations

Induction of the Mammalian GRP78/BiP Gene by Ca²⁺ Depletion and Formation of Aberrant Proteins: Activation of the Conserved Stress-Inducible grp Core Promoter Element by the Human Nuclear Factor YY1

1997 • 78 citations

Role of myc in the abrogation of IL3 dependence of myeloid FDC-P1 cells.

1987 • 75 citations

Identity of the Immunoglobulin Heavy-Chain-Binding Protein with the 78,000-Dalton Glucose-Regulated Protein and the Role of Posttranslational Modifications in Its Binding Function

1988 • 73 citations

Activation of the growth arrest and DNA damage-inducible gene gadd 153 by nephrotoxic cysteine conjugates and dithiothreitol.

1992 • 69 citations

Stress induction of the mammalian GRP78/BiP protein gene: in vivo genomic footprinting and identification of p70CORE from human nuclear extract as a DNA-binding component specific to the stress regulatory element.

1994 • 63 citations

Regulation of endoplasmic reticulum stress proteins in COS cells transfected with immunoglobulin mu heavy chain cDNA.

1991 • 63 citations

Requirement of Tyrosine- and Serine/Threonine Kinases in the Transcriptional Activation of the Mammalian grp78/BiP Promoter by Thapsigargin

1995 • 57 citations

Inactivation of Erythropoietin Receptor Function by Point Mutations in a Region Having Homology with other Cytokine Receptors

1993 • 45 citations

A Binding Site for the Cyclic Adenosine 3′,5′-Monophosphate-Response Element-Binding Protein as a Regulatory Element in the grp78 Promoter

1991 • 42 citations

The molecular response to reductive stress in LLC-PK1 renal epithelial cells: coordinate transcriptional regulation of gadd153 and grp78 genes by thiols

1997 • 37 citations

Glucose-Regulated Protein (GRP94 and GRP78) Genes Share Common Regulatory Domains and Are Coordinately Regulated by Common trans-Acting Factors

1989 • 33 citations

Tyrosine Kinase Oncogenes Abrogate Interleukin-3 Dependence of Murine Myeloid Cells through Signaling Pathways Involving c-myc: Conditional Regulation of c-myc Transcription by Temperature-Sensitive v-abl

1989 • 28 citations

Stress Induction of the Mammalian GRP78/BiP Protein Gene: In Vivo Genomic Footprinting and Identification of p70CORE from Human Nuclear Extract as a DNA-Binding Component Specific to the Stress Regulatory Element

1994 • 23 citations

Expression and Phosphorylation of BiP/GRP78, a Molecular Chaperone in the Endoplasmic Reticulum, during the Differentiation of a Mouse Myeloblastic Cell Line.

1995 • 22 citations