A peptide that binds and stabilizes p53 core domain: Chaperone strategy for rescue of oncogenic mutants

SWISS‐MODEL and the Swiss‐Pdb Viewer: An environment for comparative protein modeling

1997 • 10,943 citations

Crystal Structure of a p53 Tumor Suppressor-DNA Complex: Understanding Tumorigenic Mutations

1994 • 2,460 citations

p53 and Human Cancer: The First Ten Thousand Mutations

1999 • 968 citations

Pharmacological Rescue of Mutant p53 Conformation and Function

1999 • 794 citations

ASPP Proteins Specifically Stimulate the Apoptotic Function of p53

2001 • 656 citations

Structure of the p53 Tumor Suppressor Bound to the Ankyrin and SH3 Domains of 53BP2

1996 • 569 citations

Rescuing the function of mutant p53

2001 • 563 citations

Small peptides activate the latent sequence-specific DNA binding function of p53

1995 • 444 citations

Two cellular proteins that bind to wild-type but not mutant p53.

1994 • 423 citations

Quantitative analysis of residual folding and DNA binding in mutant p53 core domain: definition of mutant states for rescue in cancer therapy

2000 • 412 citations

Thermodynamic stability of wild-type and mutant p53 core domain

1997 • 401 citations

Restoration of the growth suppression function of mutant p53 by a synthetic peptide derived from the p53 C-terminal domain

1997 • 346 citations

Competition BIAcore for Measuring True Affinities: Large Differences from Values Determined from Binding Kinetics

1996 • 290 citations

Hot-spot mutants of p53 core domain evince characteristic local structural changes

1999 • 218 citations

Regulation of the Sequence-specific DNA Binding Function of p53 by Protein Kinase C and Protein Phosphatases

1995 • 199 citations

Stimulation of p53-mediated Transcriptional Activation by the p53-binding Proteins, 53BP1 and 53BP2

1998 • 199 citations

Strategies for manipulating the p53 pathway in the treatment of human cancer

2000 • 142 citations

Reactivation of Mutant p53 through Interaction of a C-Terminal Peptide with the Core Domain

1999 • 138 citations

Conformational and Molecular Basis for Induction of Apoptosis by a p53 C-terminal Peptide in Human Cancer Cells

1999 • 114 citations

The carboxyl-terminal domain of the p53 protein regulates sequence-specific DNA binding through its nonspecific nucleic acid-binding activity.

1995 • 101 citations

Identification of an additional negative regulatory region for p53 sequence-specific DNA binding

1998 • 86 citations

Restoration of the transcription activation function to mutant p53 in human cancer cells.

1996 • 66 citations

Proapoptotic p53-Interacting Protein 53BP2 Is Induced by UV Irradiation but Suppressed by p53

2000 • 40 citations