A role for AP-1 in apoptosis: the case for and against

AP-1 as a regulator of cell life and death

2002 • 2,752 citations

CD95's deadly mission in the immune system

2000 • 1,714 citations

Requirement of JNK for Stress- Induced Activation of the Cytochrome c-Mediated Death Pathway

2000 • 1,703 citations

AP-1 in cell proliferation and survival

2001 • 1,686 citations

Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

1997 • 1,229 citations

JNK phosphorylation of Bim-related members of the Bcl2 family induces Bax-dependent apoptosis

2003 • 1,045 citations

Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis.

1994 • 820 citations

A c-jun dominant negative mutant protects sympathetic neurons against programmed cell death

1995 • 800 citations

AP-1 in mouse development and tumorigenesis

2001 • 727 citations

DNA Damaging Agents Induce Expression of Fas Ligand and Subsequent Apoptosis in T Lymphocytes via the Activation of NF-κB and AP-1

1998 • 726 citations

Amino-terminal phosphorylation of c-Jun regulates stress-induced apoptosis and cellular proliferation

1999 • 676 citations

Dominant-Negative c-Jun Promotes Neuronal Survival by Reducing BIM Expression and Inhibiting Mitochondrial Cytochrome c Release

2001 • 568 citations

Control of cell cycle progression by c-Jun is p53 dependent

1999 • 562 citations

Withdrawal of Survival Factors Results in Activation of the JNK Pathway in Neuronal Cells Leading to Fas Ligand Induction and Cell Death

1999 • 472 citations

Liver Tumor Development

2003 • 466 citations

The Bax Subfamily of Bcl2-Related Proteins Is Essential for Apoptotic Signal Transduction by c-Jun NH₂-Terminal Kinase

2002 • 463 citations

Induction of apoptosis by the transcription factor c-Jun

1997 • 421 citations

The mammalian Jun proteins: redundancy and specificity

2001 • 333 citations

Apoptosis in Neural Development and Disease

2000 • 332 citations

Gene expression elicited by NFAT in the presence or absence of cooperative recruitment of Fos and Jun

2000 • 316 citations

BH3-only Bcl-2 Family Members Are Coordinately Regulated by the JNK Pathway and Require Bax to Induce Apoptosis in Neurons

2001 • 309 citations

JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development

1999 • 305 citations

The Mammalian UV Response

2000 • 295 citations

c-fos regulates neuronal excitability and survival

2002 • 292 citations

Functions of c-Jun in Liver and Heart Development

1999 • 274 citations

Impaired postnatal hepatocyte proliferation and liver regeneration in mice lacking c-jun in the liver

2002 • 266 citations

JunD Protects Cells from p53-Dependent Senescence and Apoptosis

2000 • 257 citations

Cooperation between STAT3 and c-Jun Suppresses Fas Transcription

2001 • 248 citations

The JNK Pathway Regulates the In Vivo Deletion of Immature CD4+CD8+ Thymocytes

1998 • 221 citations

Stress-Induced Fas Ligand Expression in T Cells Is Mediated through a MEK Kinase 1-Regulated Response Element in the Fas Ligand Promoter

1998 • 193 citations

POSH acts as a scaffold for a multiprotein complex that mediates JNK activation in apoptosis

2003 • 183 citations

c-Jun-Dependent CD95-L Expression Is a Rate-Limiting Step in the Induction of Apoptosis by Alkylating Agents

2000 • 159 citations

JunB can substitute for Jun in mouse development and cell proliferation

2002 • 156 citations

Transcriptional Regulation of the Human FasL Promoter-Enhancer Region

1998 • 156 citations

A Novel AP-1 Element in the CD95 Ligand Promoter Is Required for Induction of Apoptosis in Hepatocellular Carcinoma Cells upon Treatment with Anticancer Drugs

2000 • 132 citations

c-junis essential for sympathetic neuronal death induced by NGF withdrawal but not by p75 activation

2002 • 122 citations

Amyloid-β Induces Smac Release via AP-1/Bim Activation in Cerebral Endothelial Cells

2002 • 112 citations

Regulation of FAS Ligand Expression during Activation-Induced Cell Death in T Cells by p38 Mitogen-Activated Protein Kinase and C-Jun Nh2-Terminal Kinase

2000 • 87 citations

Jun N-terminal kinase 2 modulates thymocyte apoptosis and T cell activation through c-Jun and nuclear factor of activated T cell (NF-AT)

2001 • 87 citations

The c-fos Proto-Oncogene Is a Target for Transactivation by the p53 Tumor Suppressor

1999 • 61 citations

An unexpected role for FosB in activation-induced cell death of T cells

2003 • 54 citations

Aberrant expression of c-Fos accompanies photoreceptor cell death in therd mouse

1997 • 52 citations

Role of Activator Protein-1 in TCR-Mediated Regulation of the Murine fasl Promoter

2000 • 31 citations

Life and death in the JUNgle

2001 • 11 citations