Exploratory Chemoinformatic Analysis of Cell Type-Selective Anticancer Drug Targeting

Handbook of Molecular Descriptors

2000 • 4,065 citations

A gene expression database for the molecular pharmacology of cancer

2000 • 1,447 citations

An Information-Intensive Approach to the Molecular Pharmacology of Cancer

1997 • 1,177 citations

Chemosensitivity prediction by transcriptional profiling

2001 • 673 citations

Delocalized lipophilic cations selectively target the mitochondria of carcinoma cells

2001 • 523 citations

A novel mitochondriotoxic small molecule that selectively inhibits tumor cell growth

2002 • 224 citations

Generation of a drug resistance profile by quantitation of mdr-1/P-glycoprotein in the cell lines of the National Cancer Institute Anticancer Drug Screen.

1995 • 215 citations

Tubulin sulfhydryl groups as probes and targets for antimitotic and antimicrotubule agents

1991 • 205 citations

Interfacial properties and critical micelle concentration of lysophospholipids

1989 • 174 citations

Podophyllotoxin, steganacin and combretastatin: Natural products that bind at the colchicine site of tubulin

1993 • 172 citations

Alkyl-lysophospholipid Accumulates in Lipid Rafts and Induces Apoptosis via Raft-dependent Endocytosis and Inhibition of Phosphatidylcholine Synthesis

2002 • 165 citations

Combinatorial Approach to Organelle-Targeted Fluorescent Library Based on the Styryl Scaffold

2003 • 153 citations

Developmental Therapeutics Program at the NCI: molecular target and drug discovery process

2002 • 143 citations

Human mitochondria and mitochondrial genome function as a single dynamic cellular unit.

1994 • 142 citations

Panel of human cancer cell lines provides valuable database for drug discovery and bioinformatics

2003 • 141 citations

Mining the National Cancer Institute's Tumor-Screening Database: Identification of Compounds with Similar Cellular Activities

2002 • 134 citations

Ethidium Bromide-induced Inhibition of Mitochondrial Gene Transcription Suppresses Glucose-stimulated Insulin Release in the Mouse Pancreatic β-Cell Line βHC9

1998 • 106 citations

Pharmacogenomic analysis: correlating molecular substructure classes with microarray gene expression data

2002 • 93 citations

Nucleoside transporters in the disposition and targeting of nucleoside analogs in the kidney

2003 • 84 citations

Molecular Determinants of the Cytotoxicity of Platinum Compounds

2004 • 80 citations

Mitochondrial ABC transporters

2001 • 76 citations

F16, a Mitochondriotoxic Compound, Triggers Apoptosis or Necrosis Depending on the Genetic Background of the Target Carcinoma Cell

2004 • 74 citations

Effects of antimitotic agents on tubulin-nucleotide interactions

1991 • 73 citations

Direct photoaffinity labeling of tubulin with colchicine.

1991 • 59 citations

Functional assay of multidrug resistant cells using JC-1, a carbocyanine fluorescent probe

1997 • 58 citations

New insights into the P‐glycoprotein‐mediated effluxes of rhodamines

2003 • 55 citations

Different modes of internalization of apoptotic alkyl-lysophospholipid and cell-rescuing lysophosphatidylcholine

2003 • 54 citations

Using the National Cancer Institute Anticancer Drug Screen to Assess the Effect ofMRPExpression on Drug Sensitivity Profiles

1998 • 50 citations

N*-N*-S* Tridentate ligand system as potential antitumor agents

1981 • 46 citations

Analysis of the colchicine‐binding site of β‐tubulin

1992 • 43 citations

Kinetic Analysis of Rhodamines Efflux Mediated by the Multidrug Resistance Protein (MRP1)

2003 • 39 citations

Discrimination techniques applied to the NCI in vitro anti‐tumour drug screen: Predicting biochemical mechanism of action

1994 • 38 citations

Linking the growth inhibition response from the National Cancer Institute's anticancer screen to gene expression levels and other molecular target data

2003 • 32 citations

Chemoinformatic Analysis of a Supertargeted Combinatorial Library of Styryl Molecules

2003 • 30 citations

Toxicity of the Mitochondrial Poison Dequalinium Chloride in a Murine Model System

1993 • 24 citations

Synthesis and antineoplastic activity of mitosene analogs of the mitomycins

1981 • 23 citations

Steady-state catecholamine distribution in chromaffin granule preparations: a test of the pump-leak hypothesis of general anesthesia

1989 • 20 citations

The 2,2′-Bipyridyl-6-carbothioamide copper (II) complex differs from the iron (II) complex in its biochemical effects in tumor cells, suggesting possible differences in the mechanism leading to cytotoxicity

1996 • 12 citations

A rational approach to personalized anticancer therapy: chemoinformatic analysis reveals mechanistic gene-drug associations.

2003 • 11 citations

Antitumor activity of 2,2′-bipyridyl-6-carbothioamide: a ribonucleotide reductase inhibitor

1997 • 10 citations

Isolation of two cellular lines resistant to ribonucleotide reductase inhibitors to investigate the inhibitory activity of 2,2-bipyridyl-6-carbothioamide

1990 • 9 citations

Early onset bladder cancers show distinct clinical, pathological and molecular features

2004 • 2 citations