Applications of novel resonance energy transfer techniques to study dynamic hormone receptor interactions in living cells

Zwischenmolekulare Energiewanderung und Fluoreszenz

1948 • 7,839 citations

Evolving concepts in G protein-coupled receptor endocytosis: the role in receptor desensitization and signaling.

2001 • 1,794 citations

Specific Covalent Labeling of Recombinant Protein Molecules Inside Live Cells

1998 • 1,509 citations

Studying protein dynamics in living cells

2001 • 1,174 citations

The role of β-arrestins in the termination and transduction of G-protein-coupled receptor signals

2002 • 1,070 citations

The renaissance of fluorescence resonance energy transfer.

2000 • 963 citations

Proteomics: quantitative and physical mapping of cellular proteins

1999 • 878 citations

Receptors for Dopamine and Somatostatin: Formation of Hetero-Oligomers with Enhanced Functional Activity

2000 • 866 citations

Fluorescence lifetime imaging microscopy: spatial resolution of biochemical processes in the cell

1999 • 692 citations

Detection of β ₂ -adrenergic receptor dimerization in living cells using bioluminescence resonance energy transfer (BRET)

2000 • 631 citations

A bioluminescence resonance energy transfer (BRET) system: Application to interacting circadian clock proteins

1999 • 585 citations

Dimerization: An Emerging Concept for G Protein–Coupled Receptor Ontogeny and Function

2002 • 580 citations

Subtypes of the Somatostatin Receptor Assemble as Functional Homo- and Heterodimers

2000 • 528 citations

Imaging Protein-Protein Interactions Using Fluorescence Resonance Energy Transfer Microscopy

2001 • 524 citations

Imaging biochemistry inside cells

2001 • 453 citations

Oligomerization of epidermal growth factor receptors on A431 cells studied by time-resolved fluorescence imaging microscopy. A stereochemical model for tyrosine kinase receptor activation.

1995 • 432 citations

A CD14-independent LPS receptor cluster

2001 • 422 citations

Quantitative Imaging of Lateral ErbB1 Receptor Signal Propagation in the Plasma Membrane

2000 • 346 citations

G-protein-coupled receptors function as oligomers in vivo

2000 • 313 citations

Detection of beta 2-adrenergic receptor dimerization in living cells using bioluminescence resonance energy transfer (BRET)

2000 • 304 citations

Interaction of EGF receptor and Grb2 in living cells visualized by fluorescence resonance energy transfer (FRET) microscopy

2000 • 301 citations

Photobleaching GFP reveals protein dynamics inside live cells

1999 • 260 citations

Monitoring Receptor Oligomerization Using Time-resolved Fluorescence Resonance Energy Transfer and Bioluminescence Resonance Energy Transfer

2001 • 257 citations

Imaging into the future: visualizing gene expression and protein interactions with fluorescent proteins

2002 • 233 citations

Homo- and hetero-oligomeric interactions between G-protein-coupled receptors in living cells monitored by two variants of bioluminescence resonance energy transfer (BRET): hetero-oligomers between receptor subtypes form more efficiently than between less closely related sequences

2002 • 207 citations

Imaging FRET between spectrally similar GFP molecules in single cells

2001 • 199 citations

Constitutive and Agonist-dependent Homo-oligomerization of the Thyrotropin-releasing Hormone Receptor

2001 • 194 citations

Towards an understanding of complex protein networks

2001 • 177 citations

G protein coupled receptor dimerization: implications in modulating receptor function

2001 • 173 citations

Characterization of Sequence Determinants within the Carboxyl-terminal Domain of Chemokine Receptor CCR5 That Regulate Signaling and Receptor Internalization

2001 • 160 citations

Gonadotropin-releasing Hormone Receptor Microaggregation

2001 • 136 citations

Probing the Structure and Function of the Tachykinin Neurokinin-2 Receptor through Biosynthetic Incorporation of Fluorescent Amino Acids at Specific Sites

1996 • 133 citations

Agonist-dependent Dissociation of Oligomeric Complexes of G Protein-coupled Cholecystokinin Receptors Demonstrated in Living Cells Using Bioluminescence Resonance Energy Transfer

2001 • 125 citations

Oligomerization of the Human Thyrotropin Receptor

2001 • 115 citations

Observing proteins in their natural habitat: the living cell

2000 • 114 citations

Agonist-Induced Endocytosis and Recycling of the Gonadotropin-Releasing Hormone Receptor: Effect of β-Arrestin on Internalization Kinetics

1998 • 113 citations

Recent advances in technology for measuring and manipulating cell signals

2000 • 103 citations

The Rat Gonadotropin-Releasing Hormone Receptor Internalizes via a β-Arrestin-Independent, but Dynamin-Dependent, Pathway: Addition of a Carboxyl-Terminal Tail Confers β-Arrestin Dependency

2000 • 90 citations

Monitoring the activation state of the insulin receptor using bioluminescence resonance energy transfer.

2001 • 83 citations

Demonstration of a Homogeneous Noncompetitive Immunoassay Based on Bioluminescence Resonance Energy Transfer

2001 • 74 citations

Optimal Inhibition of X4 HIV Isolates by the CXC Chemokine Stromal Cell-derived Factor 1α Requires Interaction with Cell Surface Heparan Sulfate Proteoglycans

2001 • 68 citations

A novel approach for the identification of protein-protein interaction with integral membrane proteins

2001 • 68 citations

Binding of Agonist but Not Antagonist Leads to Fluorescence Resonance Energy Transfer between Intrinsically Fluorescent Gonadotropin-Releasing Hormone Receptors

2001 • 61 citations

Characterization of RANTES- and aminooxypentane-RANTES-triggered desensitization signals reveals differences in recruitment of the G protein-coupled receptor complex.

1999 • 57 citations

Epidermal growth factor receptor, c-erbB2 and c-erbB3 receptor interaction, and related cell cycle kinetics of SK-BR-3 and BT474 breast carcinoma cells

2001 • 51 citations

EGF-induced redistribution of erbB2 on breast tumor cells: Flow and image cytometric energy transfer measurements

1998 • 50 citations

Characterization of RANTES- and Aminooxypentane-RANTES- Triggered Desensitization Signals Reveals Differences in Recruitment of the G Protein-Coupled Receptor Complex

1999 • 48 citations

Isolation of putative plant transcriptional coactivators using a modified two‐hybrid system incorporating a GFP reporter gene

1998 • 48 citations

Subcellular Compartmentalization of Activation and Desensitization of Responses Mediated by NK2 Neurokinin Receptors

1999 • 47 citations

Measurement of proteases using chemiluminescence-resonance-energy-transfer chimaeras between green fluorescent protein and aequorin

2001 • 45 citations

Agonist‐independent and ‐dependent oligomerization of dopamine D₂ receptors by fusion to fluorescent proteins

2001 • 39 citations

A green fluorescent protein-reporter mammalian two-hybrid system with extrachromosomal maintenance of a prey expression plasmid: Application to interaction screening

2000 • 34 citations

A Homogenous 384-Well High Throughput Screen for Novel Tumor Necrosis Factor Receptor: Ligand Interactions Using Time Resolved Energy Transfer

1999 • 31 citations

Agonist-Induced Endocytosis and Recycling of the Gonadotropin-Releasing Hormone Receptor: Effect of -Arrestin on Internalization Kinetics

1998 • 29 citations

Binding of Agonist but Not Antagonist Leads to Fluorescence Resonance Energy Transfer between Intrinsically Fluorescent Gonadotropin-Releasing Hormone Receptors

2001 • 25 citations

The Rat Gonadotropin-Releasing Hormone Receptor Internalizes via a -Arrestin-Independent, but Dynamin-Dependent, Pathway: Addition of a Carboxyl-Terminal Tail Confers -Arrestin Dependency

2000 • 24 citations

Proteomics: an holistic analysis of nature's proteins

2001 • 18 citations

Mapping the Antagonist Binding Site of the Serotonin Type 3 Receptor by Fluorescence Resonance Energy Transfer

2001 • 16 citations

Membrane Recruitment Systems for Analysis of Protein-Protein Interactions

2003 • 12 citations

Fluorescent Probes: Looking Backward and Looking Forward

2000 • 9 citations