Leukemia Inhibitory Factor Modulates Interleukin-1β-Induced Activation of the Hypothalamo-Pituitary-Adrenal Axis¹

Biologic basis for interleukin-1 in disease

1996 • 4,324 citations

The Hypothalamic–Pituitary–Adrenal Axis and Immune-Mediated Inflammation

1995 • 2,525 citations

Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor

1992 • 2,004 citations

Immune-Neuro-Endocrine Interactions: Facts and Hypotheses

1996 • 1,477 citations

Association and Activation of Jak-Tyk Kinases by CNTF-LIF-OSM-IL-6 β Receptor Components

1994 • 972 citations

Defective inflammatory response in interleukin 6-deficient mice.

1994 • 540 citations

Human interleukin (IL) 1 alpha, murine IL-1 alpha and murine IL-1 beta are transported from blood to brain in the mouse by a shared saturable mechanism.

1991 • 449 citations

In the Mouse, the Activation of the Hypothalamic Pituitary-Adrenal Axis by a Lipopolysaccharide (Endotoxin) Is Mediated through Interleukin-1*

1989 • 271 citations

Differentiation inhibiting activity is produced in matrix-associated and diffusible forms that are generated by alternate promoter usage

1990 • 271 citations

Regulation of the HPA Axis by Cytokines

1995 • 270 citations

Ciliary neurotropic factor, interleukin 11, leukemia inhibitory factor, and oncostatin M are growth factors for human myeloma cell lines using the interleukin 6 signal transducer gp130.

1994 • 239 citations

IL-6 cytokine family and signal transduction: a model of the cytokine system

1996 • 238 citations

Synergistic roles of interleukin-6, interleukin-1, and tumor necrosis factor in the adrenocorticotropin response to bacterial lipopolysaccharide in vivo.

1993 • 237 citations

Modulation of leukemia inhibitory factor gene expression and protein biosynthesis in human endometrium.

1995 • 236 citations

Pituitary Cytokine and Growth Factor Expression and Action

1997 • 221 citations

Immune-neuro-endocrine interactions: facts and hypotheses

1996 • 192 citations

Effect of endotoxin in IL-1 beta-deficient mice.

1996 • 190 citations

Leukemia inhibitory factor (LIF) stimulates proopiomelanocortin (POMC) expression in a corticotroph cell line. Role of STAT pathway.

1996 • 156 citations

Effects of recombinant human interleukin-1α, -1β, 2 and 6 on ACTH synthesis and release in the mouse pituitary tumour cell line AtT-20

1989 • 145 citations

Human and murine pituitary expression of leukemia inhibitory factor. Novel intrapituitary regulation of adrenocorticotropin hormone synthesis and secretion.

1995 • 134 citations

Human Recombinant Interleukin-1Beta and -Alpha, but Not Recombinant Tumor Necrosis Factor Alpha Stimulate ACTH Release from Rat Anterior Pituitary Cells in vitro in a Prostaglandin E<sub>2</sub> and cAMP Independent Manner

1988 • 133 citations

The Leukemia Inhibitory Factor and Its Receptor

1993 • 129 citations

Pituitary follicular cells secrete an inhibitor of aortic endothelial cell growth: identification as leukemia inhibitory factor.

1992 • 122 citations

Modulation of leukemia inhibitory factor gene expression and protein biosynthesis in human endometrium

1995 • 120 citations

Synergistic roles of interleukin-6, interleukin-1, and tumor necrosis factor in the adrenocorticotropin response to bacterial lipopolysaccharide in vivo

1993 • 114 citations

Murine Leukemia Inhibitory Factor Gene Disruption Attenuates the Hypothalamo-Pituitary-Adrenal Axis Stress Response¹

1998 • 113 citations

Six different cytokines that share GP130 as a receptor subunit, induce serum amyloid A and potentiate the induction of interleukin-6 and the activation of the hypothalamus-pituitary-adrenal axis by interleukin-1

1996 • 112 citations

Interleukin-2 and interleukin-2 receptor expression in human corticotrophic adenoma and murine pituitary cell cultures.

1992 • 109 citations

Hypothalamic and pituitary leukemia inhibitory factor gene expression in vivo: a novel endotoxin-inducible neuro-endocrine interface.

1996 • 105 citations

Structural organization of the genes for murine and human leukemia inhibitory factor. Evolutionary conservation of coding and non-coding regions.

1990 • 103 citations

The Signal Transducer gp130 Is Shared by lnterleukin-6 Family of Haematopoietic and Neurotrophic Cytokines

1997 • 78 citations

Bacterial lipopolysaccharide-induced expression of interleukin-6 messenger ribonucleic acid in the rat hypothalamus, pituitary, adrenal gland, and spleen.

1993 • 77 citations

Leukemia inhibitory factor induces differentiation of pituitary corticotroph function: an immuno-neuroendocrine phenotypic switch.

1996 • 75 citations

Disrupted murine leukemia inhibitory factor (LIF) gene attenuates adrenocorticotropic hormone (ACTH) secretion.

1996 • 71 citations

A Common Pro-opiomelanocortin-binding Element Mediates Leukemia Inhibitory Factor and Corticotropin-releasing Hormone Transcriptional Synergy

1997 • 69 citations

Regulation of the Rat Proopiomelanocortin Gene Expression in AtT-20 Cells. I: Effects of the Common Secretagogues

1997 • 68 citations

Pituitary-directed leukemia inhibitory factor transgene forms Rathke's cleft cysts and impairs adult pituitary function. A model for human pituitary Rathke's cysts.

1997 • 68 citations

Pituitary Cytokine and Growth Factor Expression and Action

1997 • 67 citations

Cytokine-dependent gp130 receptor subunit regulates human fetal pituitary adrenocorticotropin hormone and growth hormone secretion.

1997 • 67 citations

Induction of Interleukin-6 Release by Interleukin-1 in Rat Anterior Pituitary Cellsin Vitro: Evidence for an Eicosanoid-Dependent Mechanism*

1991 • 64 citations

Tumor necrosis factor receptors in the pituitary cells

1997 • 62 citations

Induction of leukemia inhibitory factor in human synovial fibroblasts by IL-1 and tumor necrosis factor-alpha.

1993 • 56 citations

Molecular Identification of Two Types of lnterleukin‐1 Receptors in the Murine Pituitary Gland

1993 • 47 citations

Expression of IL-6 mRNA in normal rat and human pituitaries and in human pituitary adenomas.

1994 • 44 citations

Involvement of interleukin-1 and interleukin-1 receptor antagonist in rat pituitary cell growth regulation.

1995 • 42 citations

Production of leukemia inhibitory factor by human articular chondrocytes and cartilage in response to interleukin‐1 and tumor necrosis factor α

1993 • 40 citations

Negative regulation of cytokine gene transcription ¹

1997 • 39 citations

Bacterial lipopolysaccharide-induced expression of interleukin-6 messenger ribonucleic acid in the rat hypothalamus, pituitary, adrenal gland, and spleen

1993 • 38 citations

Hypothalamic and pituitary leukemia inhibitory factor gene expression in vivo: a novel endotoxin-inducible neuro-endocrine interface

1996 • 34 citations

Murine Leukemia Inhibitory Factor Gene Disruption Attenuates the Hypothalamo-Pituitary-Adrenal Axis Stress Response

1998 • 34 citations

Effects of cytokines on pituitary β-endorphin and adrenal corticosterone release in vitro

1996 • 32 citations

Leukemia inhibitory factor (LIF) induces acute adrenocorticotrophic hormone (ACTH) secretion in fetal rhesus macaque primates: a novel dynamic test of pituitary function.

1996 • 31 citations

Regulation of the Rat Proopiomelanocortin Gene Expression in AtT-20 Cells. I: Effects of the Common Secretagogues

1997 • 31 citations

In vitro biosynthesis of leukemia inhibitory factor/human interleukin for DA cells by human endothelial cells: differential regulation by interleukin-1 alpha and glucocorticoids

1995 • 31 citations

Interleukin-1β and tumour necrosis factor-α stimulate the mRNA expression of interleukin-1 receptors in mouse anterior pituitary AtT-20 cells

1995 • 25 citations

Disrupted murine leukemia inhibitory factor (LIF) gene attenuates adrenocorticotropic hormone (ACTH) secretion

1996 • 24 citations

Interleukin-1 increases protein kinase A activity by a cAMP-independent mechanism in AtT-20 cells

1994 • 21 citations

LIF mRNA expression is transcriptionally regulated in murine bone marrow stromal cells.

1993 • 20 citations

Nitric Oxide Plays No Role in ACTH Release Induced by Interleukin-1.BETA., Corticotropin-Releasing Hormone, Arginine Vasopressin and Phorbol Myristate Acetate in Rat Pituitary Cell Cultures.

1995 • 15 citations

Involvement of interleukin-1 and interleukin-1 receptor antagonist in rat pituitary cell growth regulation

1995 • 14 citations

Modulation of interleukin‐1 receptos in the neuro‐endocrine‐immune axis

1995 • 13 citations

Six different cytokines that share GP130 as a receptor subunit, induce serum amyloid A and potentiate the induction of interleukin-6 and the activation of the hypothalamus-pituitary-adrenal axis by interleukin-1

1996 • 9 citations

MOLECULAR-BIOLOGY OF THE LEUKEMIA INHIBITORY FACTOR GENE

1992 • 9 citations

Molecular identification of two types of interleukin-1 receptors in the murine pituitary gland

1993 • 3 citations