The Leukemia Inhibitory Factor and Its Receptor

Establishment in culture of pluripotential cells from mouse embryos

1981 • 8,424 citations

Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells.

1981 • 5,629 citations

Structural design and molecular evolution of a cytokine receptor superfamily.

1990 • 2,104 citations

Altering the Genome by Homologous Recombination

1989 • 2,021 citations

Blastocyst implantation depends on maternal expression of leukaemia inhibitory factor

1992 • 2,004 citations

Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells

1988 • 2,004 citations

Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides

1988 • 1,848 citations

Interferon beta 2/B-cell stimulatory factor type 2 shares identity with monocyte-derived hepatocyte-stimulating factor and regulates the major acute phase protein response in liver cells.

1987 • 1,667 citations

Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130

1989 • 1,411 citations

Molecular cloning and expression of an IL-6 signal transducer, gp130

1990 • 1,307 citations

Derivation of pluripotential embryonic stem cells from murine primordial germ cells in culture

1992 • 1,205 citations

IL-6 is produced by osteoblasts and induces bone resorption.

1990 • 1,121 citations

Biological and clinical aspects of interleukin 6

1990 • 1,091 citations

The IL-6 Signal Transducer, gp130: an Pncostatin M Receptor and Affinity Converter for the LIF Receptor

1992 • 897 citations

cDNA Expression Cloning of the IL-1 Receptor, a Member of the Immunoglobulin Superfamily

1988 • 896 citations

Interleukin 6 enhancement of interleukin 3-dependent proliferation of multipotential hemopoietic progenitors.

1987 • 847 citations

Ciliary neurotrophic factor prevents the degeneration of motor neurons after axotomy

1990 • 840 citations

Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor.

1989 • 711 citations

CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130

1992 • 693 citations

Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine.

1990 • 649 citations

Tumors secreting human TNF/cachectin induce cachexia in mice

1987 • 634 citations

Expression cloning of the human IL-3 receptor cDNA reveals a shared β subunit for the human IL-3 and GM-CSF receptors

1991 • 617 citations

The Receptor for Ciliary Neurotrophic Factor

1991 • 604 citations

Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130.

1991 • 587 citations

Molecular cloning and expression of cDNA encoding a murine myeloid leukaemia inhibitory factor (LIF).

1987 • 567 citations

Ciliary neurotrophic factor prevents degeneration of motor neurons in mouse mutant progressive motor neuronopathy

1992 • 559 citations

The Cholinergic Neuronal Differentiation Factor from Heart Cells Is Identical to Leukemia Inhibitory Factor

1989 • 557 citations

Uterine expression of leukemia inhibitory factor coincides with the onset of blastocyst implantation.

1991 • 507 citations

A new cytokine receptor superfamily

1990 • 506 citations

Effect of Steel factor and leukaemia inhibitory factor on murine primordial germ cells in culture

1991 • 459 citations

Interleukin-6 is a potent thrombopoietic factor in vivo in mice

1989 • 422 citations

Oncostatin M: a growth regulator produced by differentiated histiocytic lymphoma cells.

1986 • 419 citations

Involvement of IL-6 in mesangial proliferative glomerulonephritis.

1989 • 415 citations

Effects of the steel gene product on mouse primordial germ cells in culture

1991 • 405 citations

Induction of Neuronal Differentiation in PC12 Cells by B-Cell Stimulatory Factor 2/Interleukin 6

1988 • 402 citations

Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6.

1991 • 372 citations

Regulation of hepatic acute phase plasma protein genes by hepatocyte stimulating factors and other mediators of inflammation.

1990 • 335 citations

Establishment of germ-line-competent embryonic stem (ES) cells using differentiation inhibiting activity

1990 • 332 citations

Purification of a factor inducing differentiation of mouse myeloid leukemic M1 cells from conditioned medium of mouse fibroblast L929 cells.

1984 • 318 citations

Induction of neuronal differentiation in PC12 cells by B-cell stimulatory factor 2/interleukin 6.

1988 • 295 citations

Fatal syndrome in mice engrafted with cells producing high levels of the leukemia inhibitory factor.

1989 • 280 citations

Leukaemia inhibitory factor is identical to the myeloid growth factor human interleukin for DA cells

1988 • 273 citations

Hepatocyte-stimulating factor III shares structural and functional identity with leukemia-inhibitory factor.

1989 • 272 citations

Differentiation inhibiting activity is produced in matrix-associated and diffusible forms that are generated by alternate promoter usage

1990 • 271 citations

Oncostatin M as a Potent Mitogen for AIDS-Kaposi's Sarcoma-Derived Cells

1992 • 251 citations

Direct and synergistic effects of interleukin 11 on murine hemopoiesis in culture.

1991 • 234 citations

Isolation of embryonic stem (ES) cells in media supplemented with recombinant leukemia inhibitory factor (LIF)

1990 • 228 citations

Effects of injected leukemia inhibitory factor on hematopoietic and other tissues in mice

1990 • 226 citations

Purification and partial characterization of a cholinergic neuronal differentiation factor.

1985 • 211 citations

Molecular cloning and expression of the human homologue of the murine gene encoding myeloid leukemia-inhibitory factor.

1988 • 209 citations

Generation of sensory neurons is stimulated by leukemia inhibitory factor.

1991 • 208 citations

Chinese Hamster Ovarian Cells Transfected with the Murine lnterleukin-6 Gene cause Hypercalcemia as well as Cachexia, Leukocytosis and Thrombocytosis in Tumor-Bearing Nude Mice

1991 • 207 citations

Interleukin-11 regulates the hepatic expression of the same plasma protein genes as interleukin-6.

1991 • 207 citations

Recombinant oncostatin M stimulates the production of acute phase proteins in HepG2 cells and rat primary hepatocytes in vitro.

1992 • 197 citations

Leukemia Inhibitory Factor and Interleukin-6 Trigger the Same Immediate Early Response, Including Tyrosine Phosphorylation, upon Induction of Myeloid Leukemia Differentiation

1991 • 186 citations

Recombinant human interleukin 6 (B‐cell stimulatory factor 2) is a potent inducer of differentiation of mouse myeloid leukemia cells (M1)

1988 • 166 citations

Purification of a lipoprotein lipase-inhibiting protein produced by a melanoma cell line associated with cancer cachexia

1989 • 164 citations

Regulation of IL-6 expression by oncostatin M.

1991 • 157 citations

Molecular cloning of cDNA encoding adipogenesis inhibitory factor and identity with interleukin‐11

1991 • 156 citations

Interferon regulatory factor 1 is a myeloid differentiation primary response gene induced by interleukin 6 and leukemia inhibitory factor: role in growth inhibition.

1991 • 155 citations

Leukemia Inhibitory Factor: A Novel Bone-Active Cytokine*

1990 • 155 citations

Effects of ciliary neurotrophic factor (CNTF) and depolarization on neuropeptide expression in cultured sympathetic neurons

1992 • 155 citations

Stimulation of myoblast proliferation in culture by leukaemia inhibitory factor and other cytokines

1991 • 152 citations

Effects of recombinant interleukin 11 on human megakaryocyte progenitor cells.

1991 • 151 citations

Interleukin-6 signal transducer gp130 mediates oncostatin M signaling.

1992 • 147 citations

A major binding protein for leukemia inhibitory factor in normal mouse serum: identification as a soluble form of the cellular receptor.

1992 • 146 citations

Identification of the second subunit of the murine interleukin-5 receptor: interleukin-3 receptor-like protein, AIC2B is a component of the high affinity interleukin-5 receptor.

1991 • 144 citations

Purification of a murine leukemia inhibitory factor from Krebs ascites cells

1988 • 135 citations

Osteoblasts display receptors for and responses to leukemia‐inhibitory factor

1990 • 134 citations

Leukemia inhibitory factor differentiation-inhibiting activity/human interleukin for DA cells augments proliferation of human hematopoietic stem cells

1990 • 133 citations

Specific binding of murine leukemia inhibitory factor to normal and leukemic monocytic cells.

1988 • 130 citations

Resolution and purification of three distinct factors produced by Krebs ascites cells which have differentiation-inducing activity on murine myeloid leukemic cell lines.

1988 • 128 citations

Developmentally programmed induction of differentiation inhibiting activity and the control of stem cell populations.

1990 • 126 citations

Differentiation-inducing factor purified from conditioned medium of mitogen-treated spleen cell cultures stimulates bone resorption.

1986 • 125 citations

Pituitary follicular cells secrete an inhibitor of aortic endothelial cell growth: identification as leukemia inhibitory factor.

1992 • 122 citations

Differentiation inhibiting activity () and mouse development

1992 • 121 citations

Oncostatin M binds the high-affinity leukemia inhibitory factor receptor.

1992 • 117 citations

Leukemia inhibitory factor can potentiate murine megakaryocyte production in vitro

1991 • 117 citations

Human thymic epithelial cells produce IL-6, granulocyte-monocyte-CSF, and leukemia inhibitory factor.

1990 • 116 citations

Leukemia inhibitory factor sustains the survival of mouse primordial germ cells cultured on TM4 feeder layers

1991 • 116 citations

The genes for leukemia inhibitory factor and interleukin-6 are expressed in mouse blastocysts prior to the onset of hemopoiesis.

1990 • 113 citations

Molecular basis of a high affinity murine interleukin-5 receptor.

1991 • 112 citations

Clonal analysis of the actions of the murine leukemia inhibitory factor on leukemic and normal murine hemopoietic cells.

1988 • 107 citations

Distribution and comparison of receptors for leukemia inhibitory factor on murine hemopoietic and hepatic cells

1991 • 106 citations

Structural organization of the genes for murine and human leukemia inhibitory factor. Evolutionary conservation of coding and non-coding regions.

1990 • 103 citations

Cytokines and neurokines: related ligands and related receptors

1992 • 95 citations

Leukemia inhibitory factor and interleukin-6 trigger the same immediate early response, including tyrosine phosphorylation, upon induction of myeloid leukemia differentiation.

1991 • 95 citations

Developmental expression of myeloid leukemia inhibitory factor gene in preimplantation blastocysts and in extraembryonic tissue of mouse embryos.

1990 • 91 citations

Leukemia inhibitory factor/human interleukin for DA cells: a growth factor that stimulates the in vitro development of multipotential human hematopoietic progenitors

1991 • 87 citations

Production of Leukemia Inhibitory Factor in Escherichia coli by a Novel Procedure and Its Use in Maintaining Embryonic Stem Cells in Culture

1989 • 84 citations

Generation of Neuronal Diversity: Analogies and Homologies with Hematopoiesis

1990 • 79 citations

Genomic Cloning and Heterologous Expression of Human Differentiation-Stimulating Factor

1989 • 79 citations

High and low affinity receptors for human interleukin for DA cells/leukemia inhibitory factor on human cells. Molecular characterization and cellular distribution.

1992 • 77 citations

Kinetic analyses of the binding of leukemia inhibitory factor to receptor on cells and membranes and in detergent solution.

1992 • 69 citations

Characterization of interleukin-11 receptor and protein tyrosine phosphorylation induced by interleukin-11 in mouse 3T3-L1 cells.

1992 • 69 citations

Leukemia Inhibitory Factor Suppresses Proliferation, Alkaline Phosphatase Activity, and Type I Collagen Messenger Ribonucleic Acid Level and Enhances Osteopontin mRNA Level in Murine Osteoblast-Like (MC3T3E1) Cells

1990 • 68 citations

Human hepatocyte-stimulating factor-III and interleukin-6 are structurally and immunologically distinct but regulate the production of the same acute phase plasma proteins

1989 • 65 citations

LIF, the ES-cell inhibition factor, reversibly blocks nephrogenesis in cultured mouse kidney rudiments

1991 • 61 citations

The cholinergic neuronal differentiation factor from heart cell conditioned medium is different from the cholinergic factors in sciatic nerve and spinal cord

1990 • 61 citations

Clonal suppression of HL60 and U937 cells by recombinant human leukemia inhibitory factor in combination with GM-CSF or G-CSF.

1989 • 60 citations

Biochemical characterization and purification of HILDA, a human lymphokine active on eosinophils and bone marrow cells

1988 • 58 citations

Leukemia Inhibitory Factor Binds with High Affinity to Preosteoblastic RCT-1 Cells and Potentiates the Retinoic Acid Induction of Alkaline Phosphatase

1990 • 58 citations

Leukemia inhibitory factor (LIF) inhibits basal bone resorption in fetal rat long bone cultures

1990 • 58 citations

Cross‐species comparison of the sequence of the leukaemia inhibitory factor gene and its protein

1992 • 58 citations

The gene for human leukemia inhibitory factor (LIF) maps to 22q12.

1989 • 57 citations

A myelosclerotic syndrome in mice engrafted with cells producing high levels of leukemia inhibitory factor (LIF).

1989 • 57 citations

Identification and characterization of cellular receptors for the growth regulator, oncostatin M

1989 • 54 citations

Enhanced suppression of human myeloid leukemic cell lines by combinations of IL‐6, LIF, GM‐CSF and G‐CSF

1990 • 53 citations

Macrophage Differentiation Inducing Factor from Human Monocytic Cells Is Equivalent to Murine Leukemia Inhibitory Factor

1989 • 50 citations

Complete sequence of murine myeloid leukaemia inhibuitory factor (LIF)

1988 • 50 citations

Murine leukemia inhibitory factor enhances retroviral-vector infection efficiency of hematopoietic progenitors

1990 • 50 citations

Leukemia inhibitory factor improves survival of retroviral vector-infected hematopoietic stem cells in vitro, allowing efficient long-term expression of vector-encoded human adenosine deaminase in vivo.

1991 • 50 citations

Phosphorylation of the stress protein HSP27 is an early event in murine myelomonocytic leukemic cell differentiation induced by leukemia inhibitory factor/D-factor

1991 • 47 citations

Further Studies of the Distribution of CDF/LIF mRNA

2007 • 47 citations

Characterization and NH2-terminal amino acid sequence of natural human interleukin for DA cells: leukemia inhibitory factor

1989 • 43 citations

Polyfunctional cytokines : IL-6 and LIF

1992 • 41 citations

Close proximity of the genes for leukemia inhibitory factor and oncostatin M

1993 • 38 citations

Diastematomyelia and the tight filum terminale

1970 • 38 citations

Localization of the Murine Leukemia Inhibitory Factor Gene Near the Centromere on Chromosome 11

1990 • 33 citations

Structural characterization of a murine myeloid leukaemia inhibitory factor

1988 • 32 citations

Effects of leukemia inhibitory factor on bone resorption and DNA synthesis in neonatal mouse calvaria

1991 • 22 citations

Murine erythroid cell lines derived with c-myc retroviruses respond to leukemia-inhibitory factor, erythropoietin, and interleukin 3.

1991 • 21 citations

CDF/LIF selectively increases c-fos and jun-B transcripts in sympathetic neurons

1991 • 21 citations

Inhibition of development of Na⁺‐dependent hexose transport in renal epithelial LLC‐PK1 cells by differentiation‐stimulating factor for myeloid leukemic cells/leukemia inhibitory factor

1990 • 19 citations

Specific binding of a factor inducing differentiation to mouse myeloid leukemic M1 cells

1986 • 18 citations

Constitutive expression of leukemia inhibitory factor (LIF) mRNA and production of LIF by a cloned murine thymic stromal cell line.

1992 • 7 citations

D-factor and growth hormone enhance tumor necrosis factor-induced increase of Mn superoxide dismutase mRNA and oxygen tolerance

1992 • 7 citations