Cellular and molecular effects of adriamycin on dividing and nondividing cells

Radiation Biology in Cancer Research

1980 • 782 citations

The relation between cell proliferation and the vascular system in a transplanted mouse mammary tumour

1968 • 764 citations

Selective heat sensitivity of cancer cells. Biochemical and clinical studies

1967 • 728 citations

Increased accumulation of vincristine and adriamycin in drug-resistant P388 tumor cells following incubation with calcium antagonists and calmodulin inhibitors.

1982 • 667 citations

Selective heat sensitivity of cancer cells. Biochemical and clinical studies

1967 • 653 citations

A general mechanism for microsomal activation of quinone anticancer agents to free radicals.

1978 • 645 citations

Heterogeneity of tumor cells from a single mouse mammary tumor.

1978 • 582 citations

The Anticancer Agent Adriamycin Can Be Actively Cytotoxic Without Entering Cells

1982 • 578 citations

Classification of antineoplastic agents by their selective toxicities toward oxygenated and hypoxic tumor cells.

1981 • 552 citations

Thermochemotherapy: synergism between hyperthermia (42-43 degrees) and adriamycin (of bleomycin) in mammalian cell inactivation.

1975 • 489 citations

Adriamycin—A Review

1975 • 458 citations

Active efflux of daunorubicin and adriamycin in sensitive and resistant sublines of P388 leukemia.

1979 • 454 citations

THE CYTOPLASMIC SYNTHESIS OF HISTONES IN HELA CELLS AND ITS TEMPORAL RELATIONSHIP TO DNA REPLICATION

1967 • 421 citations

Effect of adriamycin on DNA, RNA, and protein synthesis in cell-free systems and intact cells.

1976 • 413 citations

In vitro selection of murine B16 melanoma variants with enhanced tissue-invasive properties.

1980 • 408 citations

Anthracycline antibiotic augmentation of microsomal electron transport and free radical formation.

1977 • 365 citations

Concepts for systemic treatment of micrometastases

1975 • 338 citations

Isolation, karyotype, and clonal growth of heterogeneous subpopulations of human malignant gliomas.

1981 • 281 citations

Heterogeneity in drug sensitivity among tumor cell subpopulations of a single mammary tumor.

1978 • 281 citations

Adriamycin (NSC-123,127): a new antibiotic with antitumor activity.

1969 • 239 citations

Clinical trials with adriamycin

1971 • 229 citations

Adriamycin (14-hydroxydaunomycin), a novel antitumor antibiotic

1969 • 218 citations

Uptake and retention of adriamycin and daunorubicin by sensitive and anthracycline-resistant sublines of P388 leukemia

1978 • 212 citations

Determination of ploidy and proliferative characteristics of human solid tumors by pulse cytophotometry.

1978 • 211 citations

Specificity of arrest, survival, and growth of selected metastatic variant cell lines.

1978 • 203 citations

Synergistic interaction of anticancer agents: a cellular perspective.

1975 • 190 citations

Mechanism of Action of Antimicrobial and Antitumor Agents

1975 • 171 citations

Heterogeneous chemosensitivities of subpopulations of human glioma cells in culture.

1982 • 170 citations

The response to chemotherapy of a variety of human tumour xenografts

1983 • 167 citations

Inhibition of DNA and RNA metabolism by daunorubicin and adriamycin in L1210 mouse leukemia.

1972 • 166 citations

Tumor cell heterogeneity : origins and implications

1982 • 159 citations

Inhibition of coenzyme Q10-enzymes, succinoxidase and NADH-oxidase, by adriamycin and other quinones having antitumor activity

1974 • 153 citations

Alteration of plasma membrane glycopeptides and gangliosides of Chinese hamster cells accompanying development of resistance to daunorubicin and vincristine.

1983 • 146 citations

Differences in drug sensitivity among tumor cells from parental tumors, selected variants, and spontaneous metastases.

1981 • 140 citations

Flow cytometry studies of intracellular adriamycin in multicell spheroids in vitro.

1981 • 134 citations

Adriamycin: A proposal on the specificity of drug action

1978 • 130 citations

N-trifluoroacetyladriamycin-14-valerate, an analog with greater experimental antitumor activity and less toxicity than adriamycin.

1975 • 129 citations

Combination chemotherapy in vitro with adriamycin. Observations of additive, antagonistic, and synergistic effects when used in two-drug combinations on cultured human lymphoma cells.

1976 • 120 citations

Lethal effect of adriamycin on the division cycle of HeLa cells.

1972 • 115 citations

Cross resistance between vinca alkaloids and anthracyclines in Ehrlich ascites tumor in vivo.

1972 • 115 citations

Cellular resistance to daunomycin in Chinese hamster cells in vitro.

1971 • 113 citations

Laser flow cytometric studies on the intracellular fluorescence of anthracyclines.

1980 • 113 citations

Effects of adriamycin on surface properties of sarcoma 180 ascites cells

1976 • 113 citations

Response of Chinese hamster ovary cells to anticancer drugs under aerobic and hypoxic conditions

1981 • 110 citations

4'-O-tetrahydropyranyladriamycin as a potential new antitumor agent.

1982 • 107 citations

Membrane-Mediated Drug Resistance and Phenotypic Reversion to Normal Growth Behavior of Chinese Hamster Cells 2

1975 • 106 citations

Adriamycin-induced changes in the surface membrane of sarcoma 180 ascites cells

1981 • 102 citations

Flow cytometry studies of intracellular adriamycin in single cells in vitro.

1981 • 97 citations

Sensitivity of different cell lines and of different phases in the cell cycle to hyperthermia.

1977 • 97 citations

Expression of epidermal and nerve growth factor receptors and soft agar growth factor production by human lung cancer cells.

1981 • 97 citations

Differential sensitivites of human melanoma cells grown in vitro to arabinosylcytosine.

1972 • 95 citations

Combined adriamycin and hyperthermia treatment of a murine mammary carcinoma in vivo.

1976 • 94 citations

Amplification of Dihydrofolate Reductase Genes in Methotrexate-resistant Cultured Mouse Cells

1978 • 93 citations

The interaction between radiation and adriamycin damage in mammalian cells.

1977 • 93 citations

Uptake and subcellular localization of daunorubicin and adriamycin in cultured fibroblasts

1978 • 88 citations

Response of aerobic and hypoxic cells in a solid tumor to adriamycin and cyclophosphamide and interaction of the drugs with radiation.

1982 • 86 citations

Flow-cytometric demonstration of tumour-cell subpopulations with different DNA content in human colo-rectal carcinoma

1979 • 85 citations

Cytotoxicity of adriamycin on aerobic and hypoxic chinese hamster V79 cells in vitro

1980 • 77 citations

Kinetic response of human lymphoid cells to adriamycin-DNA complex in vitro.

1976 • 76 citations

Obtention d'amines primaires par action d'organo-magnesiens sur l'acetoxime

1972 • 73 citations

Heterogeneity in growth pattern and drug sensitivity of primary tumor and metastases in the human tumor colony-forming assay.

1982 • 72 citations

Cyclophosphamide-adriamycin combination chemotherapy of transplantable murine tumors.

1975 • 71 citations

Cell cycle stage-dependent induction of G2 phase arrest by different antitumor agents

1978 • 71 citations

Survival and cell kinetics effects of adriamycin on mammalian cells.

1973 • 70 citations

Response of Solid Tumor Cells Exposed to Chemotherapeutic Agents In Vivo: Cell Survival After 2- and 24-Hour Exposure2

1973 • 69 citations

Comparative biochemical studies of adriamycin and daunomycin in leukemic cells.

1972 • 67 citations

Transport and storage of daunorubicin and doxorubicin in cultured fibroblasts.

1978 • 62 citations

Effects of alpha-difluoromethylornithine alone and combined with adriamycin or vindesine on L1210 leukemia in mice, EMT6 solid tumors in mice, and solid tumors induced by injection of hepatoma tissue culture cells in rats.

1981 • 62 citations

Cellular effects of combined adriamycin and x‐irradiation in human tumor cells

1977 • 58 citations

Effects of adriamycin on ultrastructure of nucleoli in the heart and liver cells of the rat.

1976 • 58 citations

Optimal schedule of methotrexate and 5-fluorouracil in human breast cancer.

1982 • 57 citations

Therapy for metastatic colorectal carcinoma with a combination of methyl-CCNU, 5-fluorouracil vincristine and streptozotocin (MOF-strep)

1980 • 55 citations

Differential response by human melanoma cells to 1,3-bis-(2-chloroethyl)-1-nitrosourea and bleomycin

1973 • 55 citations

Differential sensitivities of five rat hepatoma cell lines to anticancer drugs.

1978 • 54 citations

Patterns of cell survival following treatment with antitumor agents in vitro

1979 • 53 citations

Effect of different physiological conditions on the action of adriamycin on Chinese hamster cells in vitro

1981 • 53 citations

Enhanced glycosylation induced by adriamycin.

1979 • 53 citations

In Vitro Biological Activity of Adriamycin

1970 • 53 citations

Cell proliferation kinetics and drug sensitivity of exponential and stationary populations of cultured L1210 cells.

1977 • 52 citations

Inhibition of chicken myeloblastosis RNA polymerase II activity by adriamycin

1979 • 52 citations

Studies on recovery from chemically induced damage in mammalian cells.

1975 • 50 citations

Effects of anthracyclines on oxygenated and hypoxic tumor cells.

1983 • 49 citations

Cytofluorescence localization of anthracycline antibiotics.

1980 • 46 citations

Adriamycin-irradiation cutaneous complications

1977 • 44 citations

Comparison of adjuvant chemotherapeutic activity against primary and metastatic spontaneous murine tumors.

1977 • 42 citations

Effects of Adriamycin on the Radiation Response of Murine Hematopoietic Stem Cells

1976 • 40 citations

BIOCHEMICAL AND CARCINOSTATIC EFFECTS OF 2'-DEOXYTHIOGUANOSINE.

1964 • 40 citations

Molecular interactions and cellular changes during the cell cycle

1983 • 40 citations

Enhanced Effectiveness of Adriamycin and Bleomycin Combined with Local Hyperthermia in Neck Node Metastases from Head and Neck Cancers

1979 • 35 citations

The effect of dose rate and adriamycin on the tolerance of thoracic radiation in mice

1982 • 35 citations

A Comparison of the Lethal and Kinetic Effects of Doxorubicin and 4′-EPI-Doxorubicin in Vitro

1982 • 35 citations

Cell-cycle phase-dependence of drug-induced cycle progression delay.

1979 • 34 citations

In vivo interaction of anti-cancer drugs with misonidazole or metronidazole: methotrexate, 5-fluorouracil and adriamycin

1980 • 34 citations

Comparative effects of adriamycin and N-trifluoroacetyladriamycin-14-valerate on cell kinetics, chromosomal damage, and macromolecular synthesis in vitro.

1981 • 33 citations

Survival kinetics of cultured human lymphoma cells exposed to adriamycin.

1973 • 32 citations

Interaction between Radiation and Drug Damage in Mammalian Cells

1979 • 31 citations

Comparative uptake, metabolism and retention of anthracyclines by tumors growing in vitro and in vivo

1980 • 31 citations

Heterogeneous responses of an in vitro model of human stomach cancer to anticancer drugs

1983 • 31 citations

A comparison of adriamycin and mAMSA in vitro: Cell lethality and SCE studies

1981 • 29 citations

Enhancement of the effectiveness of daunorubicin (NSC-82151) or adriamycin (NSC-123127) against early mouse L1210 leukemia with ICRF-159 (NSC-129943).

1975 • 29 citations

Intracellular uptake of 7-con-o-methylnogarol and adriamycin by cells in culture and its relationship to cell survival.

1981 • 28 citations

Effects of aclacinomycin on cell survival and cell cycle progression of cultured mammalian cells.

1981 • 27 citations

Influence of adriamycin and adriamycin-radiation combination on jejunal proliferation in the mouse.

1977 • 26 citations

Sensitivity of G1 phase of the mitotic cycle to chromosome aberrations induced by daunomycin

1969 • 25 citations

Adriamycin resistance and radiation response

1979 • 25 citations

The usefulness of human tumor cell lines in the study of chemosensitivity. A study of malignant melanomas

1981 • 24 citations

Enhanced survival of adriamycin-treated Chinese hamster cells by 2-deoxy-D-glucose and 2,4-dinitrophenol.

1982 • 24 citations

A differential interaction of daunomycin, adriamycin, and N-trifluoroacetyladriamycin 14-valerate with mouse peritoneal macrophages.

1978 • 22 citations

Effect of 7-con-O-methylnogarol on DNA synthesis, survival, and cell cycle progression of Chinese hamster ovary cells.

1981 • 22 citations

Analytical cytometric approaches to heterogeneous cell populations in solid tumors: A review

1980 • 22 citations

Flow cytometric analysis of adriamycin-perturbed mouse mammary tumors.

1979 • 22 citations

Arrested and cycling CHO cells as a kinetic model: studies with adriamycin.

1976 • 20 citations

Enhancement of the Antitumor Activity of Adriamycin by Tween 80

1978 • 19 citations

Effect of hyperthermia, radiation and adriamycin combinations on tumor vascular function

1982 • 19 citations

The effect of adriamycin and radiation on G2 progression.

1976 • 19 citations

X-ray repair replication in L1210 leukemia cells.

1974 • 19 citations

Partial synchronization of L1210 cells by 5-fluorouracil and its use in drug combinations.

1977 • 18 citations

In vivo tumor response to single and multiple exposures of adriamycin

1980 • 18 citations

Comparison of the effects of dihydroxyanthraquinone and adriamycin on the survival of cultured Chinese hamster cells.

1982 • 18 citations

Ergebnisse der Adriamycin-Therapie

1975 • 17 citations

In vitro uptake and cytotoxicity of adriamycin in primary and metastatic lewis lung carcinoma

1979 • 16 citations

Adriamycin-Induced Chromosome Aberrations in Human Fibroblasts 2

1975 • 15 citations

Adriamycin, 1,3-bis (2-chloroethyl)-1-nitrosourea (BCNU, NSC 409962) and cyclophosphamide therapy of drug-resistant metastatic breast carcinoma

1977 • 15 citations

Biochemical and Morphological Study of Adriamycin-Induced Changes in Murine Neuroblastoma Cells

1982 • 15 citations

A phase II trial of ftorafur. Adriamycin and mitomycin-C (FAM II) in advanced gastric adenocarcinoma

1979 • 14 citations

Clonogenicity and growth of experimental tumors in relation to developing resistance and therapeutic failure.

1981 • 14 citations

Use of 1,2:5,6-dianhydrogalactitol in studies on cell kinetics-directed chemotherapy schedules in human tumors in vivo.

1982 • 14 citations

Inhibitory activity of diarylamidine derivatives on murine leukemia L1210 cell growth

1983 • 14 citations

Subcellular localization of daunorubicin in sensitive and resistant Ehrlich ascites tumor cells

1980 • 14 citations

Effect of adriamycin on the cell kinetics of 13762 rat mammary tumors and implications for therapy.

1980 • 13 citations

Pharmacological studies of 3'-(4-morpholinyl)-3'-deaminodaunorubicin in human colon carcinoma cells in vitro.

1983 • 13 citations

On the reported lack of effectiveness of daunomycin (NSC-82151) and adriamycin (NSC-123127) on solid tumors.

1972 • 13 citations

Adriamycin and cyclophosphamide in combination chemotherapy of L1210 leukemia.

1977 • 12 citations

Adriamycin effect on the Lewis lung carcinoma. Comparison between the original line and its derivative subline

1980 • 12 citations

Selective protection by anguidine of normal versus transformed cells against 1-beta-D-arabinofuranosylcytosine and Adriamycin.

1983 • 11 citations

In vitro cellular characteristics and survival responses of human astrocytoma clones to chloroethyl-nitrosoureas and dianhydrogalactitol

1983 • 10 citations

Response kinetics of host and experimental solid tumour after adriamycin

1978 • 10 citations

Effect of methylprednisolone on the cell kinetic response of C3H/HeJ mammary tumors to cyclophosphamide and adriamycin.

1979 • 9 citations

Adriamycin effects and the interactions of adriamycin with X irradiation on murine mammary tumors.

1982 • 8 citations

Toxicity of aziridinylbenzoquinone for aerobic and hypoxic cells of a transplanted mouse mammary tumor and interaction of the drug with radiation and adriamycin.

1983 • 8 citations

Adriamycin Effects and the Interactions of Adriamycin with X Irradiation on Murine Mammary Tumors

1982 • 7 citations

Cytotoxic effect of adriamycin in vivo on synchronized murine fibrosarcoma cellst

1979 • 7 citations

Murine pulmonary adenoma bioassay of potentially effective agents against slow-growing solid tumors.

1977 • 7 citations

The repair of radiation injury in L-cells treated by adriamycin

1980 • 7 citations

In vivo tumour-cell proliferation after adriamycin treatment

1982 • 6 citations

Time dependent cytotoxicity of adriamycin and daunomycin in primary cultures of normal and neoplastic mammary glands

1976 • 6 citations

Duodenal Crypt Survival and Crypt Cellular Recovery Kinetics Following Combined Treatment with Adriamycin and X Irradiation

1980 • 6 citations

Importance of schedule in adriamycin/cyclophosphamide combination chemotherapy

1978 • 5 citations

X-ray excision repair replication and radiation survival in placental mammal cells

1976 • 5 citations

Synchronisierung von Tumorzellen durch Adriamycin — Möglichkeiten der Kombinationstherapie

1975 • 4 citations

Route dependence of adriamycin effectiveness in murine osteosarcoma

1977 • 3 citations

Cytotoxicity of adriamycin combined with methotrexate against L1210 leukemia in mice.

1980 • 3 citations

Superiority of Adriamycin-14-octanoate Over Adriamycin in Reducing Viability of Methotrexate-Resistant L5178Y Cells: Brief Communication

1977 • 3 citations

Ultrastructural Alterations of Hepatic Cell Nucleoli Induced by Adriamycin

1972 • 3 citations

STUDY OF IN VITRO SENSITIVITY OF HUMAN BLADDER CANCER CELL LINES TO SEX STEROID HORMONES

1982 • 2 citations

[Certain parameters of kinetics of proliferation of small intestine epithelium after administration of carminomycin].

1982 • 1 citations