Complementary whole-genome technologies reveal the cellular response to proteasome inhibition by PS-341

Cluster analysis and display of genome-wide expression patterns

1998 • 16,410 citations

Genomic sequencing.

1984 • 8,343 citations

Functional Characterization of the S. cerevisiae Genome by Gene Deletion and Parallel Analysis

1999 • 3,929 citations

Proteasome inhibitors: a novel class of potent and effective antitumor agents.

1999 • 1,447 citations

Ubiquitin-Dependent Sorting into the Multivesicular Body Pathway Requires the Function of a Conserved Endosomal Protein Sorting Complex, ESCRT-I

2001 • 1,373 citations

Simultaneous Identification of Bacterial Virulence Genes by Negative Selection

1995 • 1,202 citations

Methods in molecular medicine.

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Quantitative phenotypic analysis of yeast deletion mutants using a highly parallel molecular bar–coding strategy

1996 • 570 citations

Genomic profiling of drug sensitivities via induced haploinsufficiency

1999 • 568 citations

Activation of a Membrane-Bound Transcription Factor by Regulated Ubiquitin/Proteasome-Dependent Processing

2000 • 561 citations

Yap1 and Skn7 Control Two Specialized Oxidative Stress Response Regulons in Yeast

1999 • 548 citations

RPN4 is a ligand, substrate, and transcriptional regulator of the 26S proteasome: A negative feedback circuit

2001 • 438 citations

The ubiquitin‐proteasome pathway and proteasome inhibitors

2001 • 428 citations

Two RING finger proteins mediate cooperation between ubiquitin-conjugating enzymes in DNA repair

2000 • 425 citations

Selective Inhibitors of the Proteasome-dependent and Vacuolar Pathways of Protein Degradation in Saccharomyces cerevisiae

1996 • 395 citations

The SWI-SNF complex: a chromatin remodeling machine?

1995 • 379 citations

Regulation of the APC and the exit from mitosis

1999 • 375 citations

Regulatory Networks Revealed by Transcriptional Profiling of DamagedSaccharomyces cerevisiaeCells: Rpn4 Links Base Excision Repair with Proteasomes

2000 • 336 citations

Rpn4p acts as a transcription factor by binding to PACE, a nonamer box found upstream of 26S proteasomal and other genes in yeast

1999 • 329 citations

Proteasome Inhibition Measurements: Clinical Application

2000 • 308 citations

SAP30, a Novel Protein Conserved between Human and Yeast, Is a Component of a Histone Deacetylase Complex

1998 • 288 citations

Proteasome Inhibitors Cause Induction of Heat Shock Proteins and Trehalose, Which Together Confer Thermotolerance in Saccharomyces cerevisiae

1998 • 226 citations

A novel complex of membrane proteins required for formation of a spherical nucleus

1998 • 222 citations

A putative protein complex consisting of Ctf19, Mcm21, and Okp1 represents a missing link in the budding yeast kinetochore

1999 • 197 citations

A Role for Ubiquitination in Mitochondrial Inheritance in Saccharomyces cerevisiae

1999 • 177 citations

Ric1p and Rgp1p form a complex that catalyses nucleotide exchange on Ypt6p

2000 • 165 citations

MGA2 or SPT23 Is Required for Transcription of the Δ9 Fatty Acid Desaturase Gene, OLE1, and Nuclear Membrane Integrity in Saccharomyces cerevisiae

1999 • 155 citations

The Complete Set of Predicted Genes from Saccharomyces cerevisiae in a Readily Usable Form

1997 • 124 citations

Transcriptional Elements Involved in the Repression of Ribosomal Protein Synthesis

1999 • 117 citations

KINETOCHORES AND THE CHECKPOINT MECHANISM THAT MONITORS FOR DEFECTS IN THE CHROMOSOME SEGREGATION MACHINERY

1998 • 113 citations

Mitochondrial morphological and functional defects in yeast caused by yme1 are suppressed by mutation of a 26S protease subunit homologue.

1994 • 109 citations

Mutation of the Rab6 Homologue of Saccharomyces cerevisiae, YPT6, Inhibits Both Early Golgi Function and Ribosome Biosynthesis

1996 • 108 citations

An orchestrated gene expression component of neuronal programmed cell death revealed by cDNA array analysis

2001 • 105 citations

A role for unsaturated fatty acids in mitochondrial movement and inheritance.

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Cut8, essential for anaphase, controls localization of 26S proteasome, facilitating destruction of cyclin and Cut2

2000 • 93 citations

Organelle Structure, Function, and Inheritance in Yeast: A Role for Fatty Acid Synthesis?

1997 • 89 citations

Exit from Mitosis

2000 • 86 citations

The yeast multidrug resistance pump, Pdr5p, confers reduced drug resistance in erg mutants of Saccharomyces cerevisiae

1999 • 82 citations

A Mutation in a Novel Yeast Proteasomal Gene,RPN11/MPR1, Produces a Cell Cycle Arrest, Overreplication of Nuclear and Mitochondrial DNA, and an Altered Mitochondrial Morphology

1998 • 74 citations

Cycloheximide-resistant temperature-sensitive lethal mutations of Saccharomyces cerevisiae.

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The IML3/MCM19 gene of Saccharomyces cerevisiae is required for a kinetochore-related process during chromosome segregation

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RIC1, a novel gene required for ribosome synthesis in Saccharomyces cerevisiae

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Proteasome Mutants, pre4-2 and ump1-2, Suppress the Essential Function but Not the Mitochondrial RNase P Function of the Saccharomyces cerevisiae Gene RPM2

2000 • 10 citations