Mutations in p53 do not account for heritable breast cancer: a study in five affected families

Mutation and Cancer: Statistical Study of Retinoblastoma

1971 • 7,335 citations

Mutations in the p53 gene occur in diverse human tumour types

1989 • 2,765 citations

T antigen is bound to a host protein in SY40-transformed cells

1979 • 2,378 citations

Chromosome 17 Deletions and p53 Gene Mutations in Colorectal Carcinomas

1989 • 2,081 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

Characterization of a 54K Dalton cellular SV40 tumor antigen present in SV40-transformed cells and uninfected embryonal carcinoma cells

1979 • 1,830 citations

Allelotype of Colorectal Carcinomas

1989 • 1,333 citations

Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation

1984 • 761 citations

Participation of p53 cellular tumour antigen in transformation of normal embryonic cells

1984 • 754 citations

Detection of a transformation-related antigen in chemically induced sarcomas and other transformed cells of the mouse.

1979 • 736 citations

Reactivity of cytosine and thymine in single-base-pair mismatches with hydroxylamine and osmium tetroxide and its application to the study of mutations.

1988 • 636 citations

P53 expression in breast cancer

1988 • 612 citations

Cellular immortalization by a cDNA clone encoding the transformation-associated phosphoprotein p53

1984 • 606 citations

Mutation is required to activate the p53 gene for cooperation with the ras oncogene and transformation

1989 • 599 citations

Localization of gene for human p53 tumour antigen to band 17p13

1986 • 498 citations

p53 cellular tumor antigen: analysis of mRNA levels in normal adult tissues, embryos, and tumors.

1985 • 380 citations

Suppression of malignancy in human cells

1976 • 313 citations

p53 and DNA polymerase α compete for binding to SV40 T antigen

1987 • 291 citations

A variation in the structure of the protein-coding region of the human p53 gene

1988 • 286 citations

Gene losses in human tumours

1988 • 280 citations

Detection of a common feature in several human tumor cell lines--a 53,000-dalton protein.

1981 • 263 citations

Meth A fibrosarcoma cells express two transforming mutant p53 species.

1988 • 247 citations

ALLELE LOSS ON SHORT ARM OF CHROMOSOME 17 IN BREAST CANCERS

1988 • 236 citations

Role of the p53 protein in cell proliferation as studied by microinjection of monoclonal antibodies.

1984 • 216 citations

Evidence implicating at least two genes on chromosome 17p in breast carcinogenesis

1990 • 205 citations

At least four different chromosomal regions are involved in loss of heterozygosity in human breast carcinoma

1989 • 198 citations

Radioimmunoassay of the cellular protein p53 in mouse and human cell lines.

1982 • 172 citations

Direct detection of point mutations by mismatch analysis: application to haemophilia B

1989 • 168 citations

Evidence that p53 behaves as a tumour suppressor gene in sporadic breast tumours.

1990 • 165 citations

p53, a transformation-related cellular-encoded protein, can be used as a biochemical marker for the detection of primary mouse tumor cells.

1983 • 154 citations

p53 gene mRNA expression and chromosome 17p allele loss in breast cancer

1990 • 120 citations

p53 Cellular Tumor Antigen: Analysis of mRNA Levels in Normal Adult Tissues, Embryos, and Tumors

1985 • 117 citations

Characterization of human p53 antigens employing primate specific monoclonal antibodies

1983 • 75 citations

Role of the p53 Protein in Cell Proliferation as Studied by Microinjection of Monoclonal Antibodies

1984 • 64 citations

p53 — Oncogene or Anti-Oncogene?

1990 • 32 citations