Mice with gene targetted prion protein alterations show that Prnp, Sine and Prni are congruent

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

1987 • 5,413 citations

THE UNLABELED ANTIBODY ENZYME METHOD OF IMMUNOHISTOCHEMISTRY PREPARATION AND PROPERTIES OF SOLUBLE ANTIGEN-ANTIBODY COMPLEX (HORSERADISH PEROXIDASE-ANTIHORSERADISH PEROXIDASE) AND ITS USE IN IDENTIFICATION OF SPIROCHETES

1970 • 5,141 citations

Mice devoid of PrP are resistant to scrapie

1993 • 2,058 citations

A novel progressive spongiform encephalopathy in cattle

1987 • 1,062 citations

Transgenetic studies implicate interactions between homologous PrP isoforms in scrapie prion replication

1990 • 874 citations

Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie.

1996 • 872 citations

Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene

1986 • 829 citations

Genetic variation among 129 substrains and its importance for targeted mutagenesis in mice

1997 • 702 citations

Separation and properties of cellular and scrapie prion proteins.

1986 • 619 citations

Fatal Familial Insomnia and Dysautonomia with Selective Degeneration of Thalamic Nuclei

1986 • 617 citations

Degenerative Disease of the Central Nervous System in New Guinea

1957 • 570 citations

ENCEPHALOPATHY IN MICE PRODUCED BY INOCULATION WITH SCRAPIE BRAIN MATERIAL

1961 • 505 citations

Transmission of bovine spongiform encephalopathy and scrapie to mice: strain variation and the species barrier

1994 • 489 citations

Distinct prion proteins in short and long scrapie incubation period mice

1987 • 482 citations

The sequential development of the brain lesions of scrapie in three strains of mice

1968 • 463 citations

Ablation of the prion protein (PrP) gene in mice prevents scrapie and facilitates production of anti-PrP antibodies.

1993 • 461 citations

Identification of a gene which controls the incubation period of some strains of scrapie agent in mice

1968 • 425 citations

Germ line transmission and expression of a corrected HPRT gene produced by gene targeting in embryonic stem cells

1989 • 423 citations

Linkage of prion protein and scrapie incubation time genes

1986 • 405 citations

The disease characteristics of different strains of scrapie in Sinc congenic mouse lines: implications for the nature of the agent and host control of pathogenesis

1991 • 385 citations

The major polypeptide of scrapie-associated fibrils (SAF) has the same size, charge distribution and N-terminal protein sequence as predicted for the normal brain protein (PrP).

1986 • 322 citations

Über eigenartige erkrankungen des zentralnervensystems mit bemerkenswertem anatomischen befunde

1921 • 300 citations

Über eine eigenartige herdförmige erkrankung des zentralnervensystems (Vorläufige mitteilung)

1920 • 299 citations

Identification of prion amyloid filaments in scrapie-infected brain

1985 • 293 citations

Precise targeting of the pathology of the sialoglycoprotein, PrP, and vacuolar degeneration in mouse scrapie

1989 • 277 citations

PrP gene dosage determines the timing but not the final intensity or distribution of lesions in scrapie pathology.

1994 • 267 citations

Interactions between wild-type and mutant prion proteins modulate neurodegeneration in transgenic mice.

1996 • 253 citations

A new mouse embryonic stem cell line with good germ line contribution and gene targeting frequency

1992 • 249 citations

Replication of distinct scrapie prion isolates is region specific in brains of transgenic mice and hamsters.

1992 • 213 citations

Transmission of bovine spongiform encephalopathy and scrapie to mice

1992 • 199 citations

Linkage of the Scrapie-associated Fibril Protein (PrP) Gene and Sinc Using Congenic Mice and Restriction Fragment Length Polymorphism Analysis

1987 • 159 citations

Genetics and polymorphism of the mouse prion gene complex: control of scrapie incubation time.

1988 • 157 citations

Prion isolate specified allotypic interactions between the cellular and scrapie prion proteins in congenic and transgenic mice.

1994 • 154 citations

Post-mortem immunodiagnosis of scrapie and bovine spongiform encephalopathy

1989 • 154 citations

Accumulation of proteinase K-resistant prion protein (PrP) is restricted by the expression level of normal PrP in mice inoculated with a mouse-adapted strain of the Creutzfeldt-Jakob disease agent

1995 • 139 citations

Paradoxical shortening of scrapie incubation times by expression of prion protein transgenes derived from long incubation period mice

1991 • 136 citations

Neuropathology of spongiform encephalopathies in humans

1993 • 115 citations

Structure and polymorphism of the mouse prion protein gene.

1994 • 104 citations

Genetic control of scrapie and Creutzfeldt-Jakob disease in mice.

1983 • 104 citations

Distribution of Experimentally Induced Scrapie Lesions in the Brain

1967 • 96 citations

Pathology and Immunocytochemistry of a Kuru Brain

1997 • 77 citations

Double Replacement Gene Targeting for the Production of a Series of Mouse Strains with Different Prion Protein Gene Alterations

1995 • 65 citations

Analysis of linkage between scrapie incubation period and the prion protein gene in mice

1990 • 64 citations

Genetic Control of Amyloid Plaque Production and Incubation Period in Scrapie-infected Mice

1985 • 56 citations

Genetical control of the incubation period in mice of the neurological disease, scrapie

1964 • 51 citations

Characterisation of two promoters for prion protein (PrP) gene expression in neuronal cells

1997 • 48 citations

Are Sinc and the PrP gene congruent? Evidence from PrP gene analysis in Sinc congenic mice

1992 • 34 citations

Delimiting the location of the scrapie prion incubation time gene on chromosome 2 of the mouse.

1993 • 34 citations

Protease-resistant PrP deposition in brain and non-central nervous system tissues of a murine model of bovine spongiform encephalopathy

1996 • 31 citations