Comparative induction of aryl hydrocarbon hydroxylase activity in vitro by analogues of dibenzo-p-dioxin

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Limits for qualitative detection and quantitative determination. Application to radiochemistry

1968 • 4,188 citations

Substrate-inducible Microsomal Aryl Hydroxylase in Mammalian Cell Culture

1968 • 1,691 citations

Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase.

1976 • 1,343 citations

Results of a two-year chronic toxicity and oncogenicity study of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats

1978 • 1,054 citations

Case-control study: Soft-tissue sarcomas and exposure to phenoxyacetic acids or chlorophenols

1979 • 419 citations

The comparative toxicity of chlorinated dibenzo-p-dioxins in mice and guinea pigs

1978 • 387 citations

Epidemiologic study on Yusho, a Poisoning Caused by Ingestion of Rice Oil Contaminated with a Commercial Brand of Polychlorinated Biphenyls

1972 • 372 citations

Chlorinated biphenyl induction of aryl hydrocarbon hydroxylase activity: a study of the structure-activity relationship.

1977 • 347 citations

Genetic Expression of Aryl Hydrocarbon Hydroxylase Activity

1974 • 326 citations

HEPATOMAS IN TISSUE CULTURE COMPARED WITH ADAPTING LIVER IN VIVO.

1964 • 314 citations

The Toxicity of Polychlorinated Polycyclic Compounds and Related Chemicals

1973 • 310 citations

The fate of 2,3,7,8-tetrachlorodibenzo-p-dioxin following single and repeated oral doses to the rat

1976 • 303 citations

Comparison of 2,3,7,8-tetrachlorodibenzo-p-dioxin, a potent inducer of aryl hydrocarbon hydroxylase, with 3-methylcholanthrene.

1974 • 293 citations

A Transplantable Bile-Secreting Hepatocellular Carcinoma in the Rat<xref ref-type="fn" rid="FN1">2</xref><xref ref-type="fn" rid="FN2">3</xref>

1961 • 248 citations

Genetic expression of aryl hydrocarbon hydroxylase activity in the mouse

1975 • 245 citations

Genetic Expression of Aryl Hydrocarbon Hydroxylase by 2,3,7,8-Tetrachlorodibenzo-p-dioxin: Evidence for a Receptor Mutation in Genetically Non-responsive Mice

1975 • 238 citations

Induction of multiple forms of mouse liver cytochrome P-450. Evidence for genetically controlled de novo protein synthesis in response to treatment with beta-naphthoflavone or phenobarbital.

1976 • 229 citations

Chlorinated dibenzo-p-dioxins: potent inducers of delta-aminolevulinic acid synthetase and aryl hydrocarbon hydroxylase. II. A study of the structure-activity relationship.

1973 • 218 citations

The Ah Locus and the Metabolism of Chemical Carcinogens and Other Foreign Compounds

1977 • 188 citations

The genetics of aryl hydrocarbon hydroxylase induction in mice: A single gene difference between C57BL/6J and DBA/2J

1972 • 184 citations

An analytical method for detecting TCDD (dioxin): levels of TCDD in samples from Vietnam.

1973 • 162 citations

Induction and suppression of hepatic and extrahepatic microsomal foreign-compound-metabolizing enzyme systems by 2,3,7,8-tetrachlorodibenzo-p-dioxin

1975 • 142 citations

Etiology of chick edema disease.

1973 • 113 citations

Preparation and characterization of chlorinated dibenzo-p-dioxins

1972 • 113 citations

Induction of Enzyme Activity in Cell Culture: A Rapid Screen for Detection of Planar Poly chlorinated Organic Compounds

1979 • 112 citations

Aryl hydrocarbon hydroxylase induction in mammalian liver-derived cell cultures. Stimulation of "cytochrome P1-450-associated" enzyme activity by many inducing compounds.

1975 • 109 citations

Effects of pentachlorophenol on hepatic drug-metabolizing enzymes and porphyria related to contamination with chlorinated dibenzo-p-dioxins and dibenzofurans

1977 • 104 citations

A review of the genetic toxicology of chlorinated dibenzo-p-dioxins

1977 • 100 citations

Cytosolic receptor for aryl hydrocarbon hydroxylase induction by polycyclic aromatic compounds. Evidence for structural and regulatory variants among established cell cultured lines.

1977 • 96 citations

Chromatographic evidence for the formation of chlorodioxins from chloro-2-phenoxyphenols

1974 • 92 citations

Yusho, a Poisoning Caused by Rice Oil Contaminated with Polychlorinated Biphenyls

1971 • 86 citations

Chlorodioxins—Origin and Fate

1973 • 81 citations

Induction of Aryl Hydrocarbon Hydroxylase Activity in Various Cell Cultures by 2,3,7,8-Tetrachlorodibenzo-p-dioxin

1975 • 75 citations

A transplantable bile-secreting hepatocellular carcinoma in the rat

1962 • 74 citations

Aryl hydrocarbon hydroxylase induction in human lymphocyte cultures by 2,3,7,8-tetrachlorodibenzo--dioxin

1974 • 74 citations

2,3,7,8-tetrachlorodibenzo-p-dioxin as cocarcinogen causing 3-methylcholanthrene-initiated subcutaneous tumors in mice genetically "nonresponsive" at Ah locus.

1978 • 73 citations

Relationship between "aromatic hydrocarbon responsiveness" and the survival times in mice treated with various drugs and environmental compounds.

1975 • 72 citations

Guiding concepts relating to trace analysis

1973 • 71 citations

Synthesis and Fourier transform carbon-13 spectroscopy of new toxic polyhalodibenzo-p-dioxins

1974 • 71 citations

Postnatal stimulation of hepatic microsomal enzymes following administration of TCDD to pregnant rats

1975 • 70 citations

Importance of genetic factors influencing the metabolism of foreign compounds.

1976 • 66 citations

Genetic expression of aryl hydrocarbon hydroxylase activity in the mouse

1975 • 65 citations

Detailed examination of polychlorinated dibenzofurans in PCB preparations and Kanemi Yusho oil

1977 • 63 citations

Aryl hydrocarbon hydroxylase induction in mammalian liver cell culture—IV. Stimulation of the enzyme activity in established cell lines derived from rat or mouse hepatoma and from normal rat liver

1973 • 62 citations

Organ specific induction of drug metabolizing enzymes by 2,3,7,8-tetrachlorodibenzo-p-dioxin in the rat

1978 • 56 citations

Differential induction of murine Ah locus-associated monooxygenase activities in rabbit liver and kidney

1975 • 45 citations

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on mammalian cells in tissue cultures

1975 • 45 citations

2,3,7,8-Tetrachlorodibenzo-p-dioxin induction of aryl hydrocarbon hydroxylase in female rat liver. Evidence for de novo synthesis of cytochrome P-448.

1978 • 40 citations

PROPERTIES OF THE H-4-II-E TUMOR CELL SYSTEM.

1977 • 40 citations

Intervention of the smiles rearrangement in syntheses of dibenzo--dioxins. 1,2,3,6,7,8- and 1,2,3,7,8,9-hexachlorodibenzo--dioxin (hcdd)

1975 • 40 citations

Aryl hydrocarbon hydroxylase induction in mammalian liver-derived cell cultures

1976 • 39 citations

Transplacental induction of carcinogen-hydroxylating systems with 2,3,7,8-tetrachlorodibenzo-p-dioxin

1976 • 35 citations

Graphic representation of nuclear magnetic resonance proton chemical shifts for the acyclic methine group

1968 • 31 citations

Studies on the Compounds Related to PCB (V)

1978 • 22 citations

Determination of polychlorodibenzo-p-dioxins and polychlorodibenzofurans in commercial gelatins by gas-liquid chromatography

1977 • 22 citations

Effects of environmental chemicals on the genetic regulation of microsomal enzyme systems

1977 • 20 citations

Health hazards from chemical impurities: chlorinated dibenzodioxins and chlorinated dibenzofurans

1974 • 18 citations

ChemInform Abstract: SYNTHESIS AND FOURIER TRANSFORM CARBON‐13 NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY OF NEW TOXIC POLYHALODIBENZO‐P‐DIOXINS

1974 • 15 citations

Les polychloro dibenzo-p-dioxines

1975 • 6 citations