Characterization of Intracellular Calcium Responses Produced by Polycyclic Aromatic Hydrocarbons in Surface Marker-Defined Human Peripheral Blood Mononuclear Cells

Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture.

1970 • 1,464 citations

Immunotoxicology and immunopharmacology

1986 • 428 citations

Signal Transduction by the B Cell Antigen Receptor and its Coreceptors

1994 • 419 citations

Cell Surface Molecules and Early Events Involved in Human T Lymphocyte Activation

1987 • 297 citations

Immunotoxicology and immunopharmacology

1995 • 253 citations

Human T Cells Are Highly Sensitive to Suppression of Mitogenesis by Polycyclic Aromatic Hydrocarbons and This Effect Is Differentially Reversed by α-Naphthoflavone

1996 • 150 citations

Improved sensitivity in flow cytometric intracellular ionized calcium measurement using fluo‐3/Fura Red fluorescence ratios

1994 • 136 citations

2,3,7,8-Tetrachlorodibenzo-p-Dioxin-Induced Changes in Immunocompetence: Possible Mechanisms

1991 • 130 citations

Role of alterations in ca²⁺‐associated signaling pathways in the immunotoxicity of polycyclic aromatic hydrocarbons

1995 • 109 citations

Immunosuppression following 7,12-dimethylbenz[a]anthracene exposure in B6C3F1 mice. I. Effects on humoral immunity and host resistance

1984 • 103 citations

Molecular and Cellular Basis of Chemically Induced Immunotoxicity

1987 • 101 citations

Immunosuppression by polycyclic aromatic hydrocarbons: A structure-activity relationship in B6C3F1 and DBA/2 mice

1985 • 97 citations

Direct suppression of in vitro antibody production by mouse spleen cells by the carcinogen benzo(a)pyrene but not by the noncarcinogenic congener benzo(e)pyrene.

1984 • 87 citations

Different patterns of calcium signaling triggered through two components of the B lymphocyte antigen receptor.

1994 • 71 citations

7,12-Dimethylbenz[a]anthracene activates protein-tyrosine kinases Fyn and Lck in the HPB-ALL human T-cell line and increases tyrosine phosphorylation of phospholipase C-gamma 1, formation of inositol 1,4,5-trisphosphate, and mobilization of intracellular calcium.

1993 • 71 citations

Depletion of Glutathione by Benzo(a)pyrene Metabolites, Ionomycin, Thapsigargin, and Phorbol Myristate in Human Peripheral Blood Mononuclear Cells

1997 • 62 citations

Suppression of the in vitro humoral immune response of mouse splenocytes by 7,12-dimethylbenz[a]anthracene metabolites and inhibition of immunosuppression by α-naphthoflavone

1991 • 61 citations

Effects of Benzo[a]pyrene on Concanavalin A-Stimulated Human Peripheral Blood Mononuclear cells in Vitro: Inhibition of Proliferation but No Effect on Parameters Related to the G1 Phase of the Cell Cycle

1993 • 55 citations

Inhibition of Sarcoplasmic/Endoplasmic Reticulum Calcium ATPases (SERCA) by Polycyclic Aromatic Hydrocarbons in HPB-All Human T Cells and Other Tissues

1995 • 52 citations

Persistence of Calcium Elevation in the HPB-ALL Human T Cell Line Correlates with Immunosuppressive Properties of Polycyclic Aromatic Hydrocarbons

1994 • 51 citations

DMBA Induces Programmed Cell Death (Apoptosis) in the A20.1 Murine B Cell Lymphoma

1993 • 49 citations

Persistent suppression of humoral and cell-mediated immunity in mice following exposure to the polycyclic aromatic hydrocarbon 7,12-dimethylbenz[a]anthracene

1986 • 45 citations

Molecular Mechanisms of Toxicant-Induced Immunosuppression: Role of Second Messengers

1996 • 44 citations

Inhibition of lymphocyte activation in splenic and gut-associated lymphoid tissues following oral exposure of mice to 7,12-dimethylbenz[a]anthracene

1990 • 41 citations

Persistent suppression of humoral immunity produced by 7,12-dimethylbenz(a)anthracene (DMBA) in B6C3F1 mice: Correlation with changes in spleen cell surface markers detected by flow cytometry

1988 • 36 citations

Alterations in mitogen-induced calcium mobilization and intracellular free calcium produced by 7,12-dimethylbenz(a)anthracene in the Jurkat human T cell line

1991 • 34 citations

Metabolism of benzo[a]pyrene by murine splenic cell types

1992 • 31 citations

Molecular mechanism of 7,12-dimethylbenz[a]anthracene-induced immunosuppression: evidence for action via the interleukin-2 pathway.

1989 • 29 citations

Inhibition of calcium-dependent pathways of B-cell activation by DMBA

1992 • 18 citations

Inhibition of Calcium-Dependent B Cell Activation by 2,3,7,8-Tetrachlorodibenzo-p-dioxin

1994 • 17 citations

Immune modification due to chemical interference with transmembrane signalling: Application to polycyclic aromatic hydrocarbons

1992 • 15 citations

The role of cytoplasmic free calcium concentration in B-cell tolerance

1987 • 8 citations

Development of a Human Peripheral Blood Mononuclear Leukocyte Model for Immunotoxicity Evaluation

1991 • 2 citations