Suppression of the in vitro humoral immune response of mouse splenocytes by 7,12-dimethylbenz[a]anthracene metabolites and inhibition of immunosuppression by α-naphthoflavone

Nonparametric Statistical Methods.

1974 • 2,964 citations

Simultaneous analysis of families of sigmoidal curves: application to bioassay, radioligand assay, and physiological dose-response curves.

1978 • 2,400 citations

Macrophages synthesise and release prostaglandins in response to inflammatory stimuli

1977 • 573 citations

Immunotoxicology and immunopharmacology

1986 • 428 citations

Genetic expression of aryl hydrocarbon hydroxylase induction. IV. Interaction of various compounds with different forms of cytochrome P-450 and the effect on benzo(a)pyrene metabolism in vitro.

1972 • 180 citations

A 7-Hydroxymethyl Sulfate Ester as an Active Metabolite of 7,12-Dimethylbenz[ a ]anthracene

1982 • 178 citations

Ontogenetic expression of polycyclic aromatic compound-inducible monooxygenase activities and forms of cytochrome P-450 in rabbit. Evidence for temporal control and organ specificity of two genetic regulatory systems.

1977 • 164 citations

Free Radicals and Cancer

1983 • 127 citations

Evidence that binding of 7,12-dimethylbenz(a)anthracene to DNA in mouse embryo cell cultures results in extensive substitution of both adenine and guanine residues.

1983 • 116 citations

Immunosuppression following 7,12-dimethylbenz[a]anthracene exposure in B6C3F1 mice. I. Effects on humoral immunity and host resistance

1984 • 103 citations

Selective immunosuppression resulting from exposure to the carcinogenic congener of benzopyrene in B6C3F1 mice.

1983 • 99 citations

Immunosuppression by polycyclic aromatic hydrocarbons: A structure-activity relationship in B6C3F1 and DBA/2 mice

1985 • 97 citations

Potent tumor-initiating activity of the 3,4-dihydrodiol of 7,12-dimethylbenz(a)anthracene in mouse skin.

1979 • 93 citations

Metabolism of benzo (a) pyrene to reactive intermediate (S) via prostaglandin biosynthesis

1978 • 87 citations

Direct suppression of in vitro antibody production by mouse spleen cells by the carcinogen benzo(a)pyrene but not by the noncarcinogenic congener benzo(e)pyrene.

1984 • 87 citations

Products of binding of 7,12-dimethylbenz(a)anthracene to DNA in mouse skin.

1983 • 82 citations

Suppression of the vitro humoral immune response of mouse splenocytes by benzo(a)pyrene metabolites and inhibition of benzo(a)pyrene-induced immunosuppression by alpha-naphthoflavone.

1987 • 77 citations

Immunosuppression following 7,12-dimethylbenz[a]anthracene exposure in B6C3F1 mice—II. Altered cell-mediated immunity and tumor resistance

1986 • 71 citations

Alterations in cell-mediated immune functions induced in mouse splenic lymphocytes by polycyclic aromatic hydrocarbons.

1984 • 70 citations

Effects of N-nitrosodimethylamine on humoral immunity.

1984 • 69 citations

Biotransformation and Bioactivation of 7,12-Dimethylbenz[a]anthracene (7,12-DMBA)

1980 • 64 citations

Comparison of benzo(a)pyrene and (-)-trans-7,8-dihydroxy-7,8-dihydrobenzo(a)pyrene metabolism in human blood monocytes and lymphocytes.

1979 • 61 citations

Immunosuppression following exposure to 7,12-dimethylbenz[a]anthracene (DMBA) in Ah-responsive and Ah-nonresponsive mice

1987 • 60 citations

Immunomodulation by polyaromatic hydrocarbons in mice and murine cells.

1986 • 55 citations

DNA adduct formation in mouse tissues in relation to serum levels of benzo(a)pyrene-diol-epoxide after injection of benzo(a)pyrene or the diol-epoxide.

1990 • 51 citations

Comparison of metabolism-mediated binding to DNA of 7-hydroxymethyl-12-methylbenz(a)anthracene and 7, 12-dimethylbenz(a)anthracene.

1979 • 48 citations

Transport of DNA-adducting metabolites in mouse serum following benzo [a]pyrene administration

1989 • 45 citations

Identification of 7,12-dimethylbenz[ a ]anthracene metabolites that lead to mutagenesis in mammalian cells

1979 • 44 citations

Suppression of T-helper cell function in mice following exposure to the carcinogen 7,12-dimethylbenz[a]anthracene and its restoration by interleukin-2

1987 • 43 citations

Suppression of splenic lymphocyte function by 7,12-dimethylbenz[a]anthracene (DMBA) in vitro

1988 • 42 citations

Identification of four trans-3,4-dihydrodiol metabolites of 7,12-dimethylbenz[a]anthracene and their in vitro DNA-binding activities upon further metabolism.

1978 • 41 citations

Inhibition of lymphocyte activation in splenic and gut-associated lymphoid tissues following oral exposure of mice to 7,12-dimethylbenz[a]anthracene

1990 • 41 citations

³²P-Postlabeling analysis of DNA adducts in human and rat mammary epithelial cells

1988 • 34 citations

Benzo(a)pyrene metabolism by murine spleen microsomes.

1989 • 31 citations

Evidence for a free-radical-dependent metabolism of 7,12-dimethylbenz(a)anthracene in rat testis

1987 • 30 citations

Induction of immunotoxicity by polycyclic hydrocarbons: Role of the Ah locus

1984 • 30 citations

Effects of methylcholanthrene and benzanthracene on blastogenesis and aryl hydrocarbon hydroxylase induction in splenic lymphocytes from three inbred strains of mice

1983 • 29 citations

The effect of phenobarbital, 3-methylcholanthrene, 3,4-benzpyrene, and pregnenolone-16α-carbonitrile on microsomal heme oxygenase and splenic cytochrome P-450

1974 • 21 citations

The effects of epoxidized xenobiotics on mitogen responsiveness and antibody-producing ability of murine spleen cells in vitro

1991 • 11 citations

Functional and biochemical disposition of 7,12-dimethylbenz[a]anthracene in murine lymphoid cells

1989 • 11 citations

Aryl Hydrocarbon (Benzo[a]pyrene) Hydroxylase in Guinea Pig Lymphoid Tissue<xref ref-type="fn" rid="FN2">2</xref>

1981 • 4 citations

Effect of 7,12‐ dimethylbenz (A) anthracene (DMBA) on signal transduction following activation of human peripheral blood lymphocytes

1992 • 1 citations