Targeted Disruption of the β3-Adrenergic Receptor Gene

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular cloning: A laboratory manual

1990 • 85,659 citations

A simple salting out procedure for extracting DNA from human nucleated cells

1988 • 20,341 citations

Metabolism of Isolated Fat Cells

1964 • 4,431 citations

Targeted mutation of the DNA methyltransferase gene results in embryonic lethality

1992 • 3,907 citations

Altering the Genome by Homologous Recombination

1989 • 2,021 citations

Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes

1988 • 1,690 citations

MyoD or Myf-5 is required for the formation of skeletal muscle

1993 • 1,663 citations

The Cloning of a Family of Genes That Encode the Melanocortin Receptors

1992 • 1,616 citations

Hypothalamic and genetic obesity in experimental animals: an autonomic and endocrine hypothesis.

1979 • 1,145 citations

Molecular Characterization of the Human β ₃ -Adrenergic Receptor

1989 • 1,071 citations

Development of obesity in transgenic mice after genetic ablation of brown adipose tissue

1993 • 1,057 citations

Inactivation of MyoD in mice leads to up-regulation of the myogenic HLH gene Myf-5 and results in apparently normal muscle development

1992 • 973 citations

Methods for the determination of adipose cell size in man and animals

1968 • 896 citations

Atypical β-adrenoceptor on brown adipocytes as target for anti-obesity drugs

1984 • 724 citations

Comparison of three actin-coding sequences in the mouse; Evolutionary relationships between the actin genes of warm-blooded vertebrates

1986 • 678 citations

Fat cell adrenergic receptors and the control of white and brown fat cell function

1993 • 640 citations

Genetic Variation in the β₃-Adrenergic Receptor and an Increased Capacity to Gain Weight in Patients with Morbid Obesity

1995 • 620 citations

Time of Onset of Non-Insulin-Dependent Diabetes Mellitus and Genetic Variation in the β₃-Adrenergic–Receptor Gene

1995 • 602 citations

Association of a Polymorphism in the β₃-Adrenergic–Receptor Gene with Features of the Insulin Resistance Syndrome in Finns

1995 • 552 citations

Adipose cell hyperplasia and enhanced glucose disposal in transgenic mice overexpressing GLUT4 selectively in adipose tissue.

1993 • 510 citations

Highly efficient gene targeting in embryonic stem cells through homologous recombination with isogenic DNA constructs.

1992 • 450 citations

Adenyl Cyclase in Fat Cells

1969 • 437 citations

Cloning and expression of the mouse pgk-1 gene and the nucleotide sequence of its promoter

1987 • 361 citations

Brown adipose tissue thermogenesis and obesity

1989 • 329 citations

β₃ and Atypical β‐Adrenoceptors

1993 • 313 citations

cAMP-dependent protein kinase and lipolysis in rat adipocytes. I. Cell preparation, manipulation, and predictability in behavior.

1985 • 302 citations

An adipose tissue-specific beta-adrenergic receptor. Molecular cloning and down-regulation in obesity.

1991 • 291 citations

Molecular cloning and expression of the rat beta 3-adrenergic receptor.

1991 • 289 citations

Disodium (R,R)-5-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]-1,3-benzodioxole-2,2-dicarboxylate (CL 316,243). A potent .beta.-adrenergic agonist virtually specific for .beta.3 receptors. A promising antidiabetic and antiobesity agent

1992 • 286 citations

Molecular characterization of the mouse beta 3-adrenergic receptor: relationship with the atypical receptor of adipocytes.

1991 • 277 citations

Structural basis for receptor subtype-specific regulation revealed by a chimeric beta 3/beta 2-adrenergic receptor.

1993 • 227 citations

Adenosine release from isolated fat cells and its significance for the effects of hormones on cyclic 3?,5?-AMP levels and lipolysis

1973 • 211 citations

Beta-adrenergic, cAMP-mediated stimulation of proliferation of brown fat cells in primary culture. Mediation via beta 1 but not via beta 3 adrenoceptors.

1992 • 189 citations

Effect of dietary fat content on the incidence of obesity among ad libitum fed mice.

1985 • 188 citations

The human beta 3-adrenergic receptor is resistant to short term agonist-promoted desensitization.

1993 • 173 citations

The human β3-adrenoceptor: the search for a physiological function

1994 • 160 citations

Agonist and antagonist characterization of a putative adrenoceptor with distinct pharmacological properties from the α‐ and β‐subtypes

1988 • 152 citations

Is the adipocyte β-adrenoceptor a prototype for the recently cloned atypical ‘β3-adrenoceptor?’

1990 • 147 citations

Determinations of adipose cell size and number in suspensions of isolated rat and human adipose cells

1978 • 125 citations

Radiometric assays for glycerol, glucose, and glycogen

1989 • 121 citations

Long-term agonist exposure induces upregulation of beta 3-adrenergic receptor expression via multiple cAMP response elements.

1992 • 120 citations

Coexisting beta-adrenoceptor subtypes: significance for thermogenic process in brown fat cells

1994 • 114 citations

Targeted correction of a major histocompatibility class II E alpha gene by DNA microinjected into mouse eggs.

1989 • 113 citations

The promoter and intron/exon structure of the human and mouse β3‐adrenergic‐receptor genes

1993 • 100 citations

Direct evidence for the atypical nature of functional β‐adrenoceptors in rat adipocytes

1989 • 99 citations

Desensitization of beta-1 and beta-2, but not beta-3, adrenoceptor-mediated lipolytic responses of adipocytes after long-term norepinephrine infusion.

1993 • 91 citations

Rodent and human beta 3-adrenergic receptor genes contain an intron within the protein-coding block.

1992 • 88 citations

Inhibition of adenosine cyclic 3', 5'-monophosphate accumulation in fat cells by adenosine, N6-(phenylisopropyl) adenosine, and related compounds.

1973 • 87 citations

Effects of agonist exposure on the coupling of beta 1 and beta 3 adrenergic receptors to adenylyl cyclase in isolated adipocytes.

1992 • 84 citations

Multiple beta adrenergic receptor subclasses mediate the l-isoproterenol-induced lipolytic response in rat adipocytes.

1992 • 57 citations

Cell-specific down-regulation of the beta 3-adrenergic receptor.

1994 • 56 citations

Multiplex Solution Hybridization‐Ribonuclease Protection Assay for Quantitation of Different Ribonucleic Acid Transcripts from Snap‐Frozen Neuroendocrine Tissues of Individual Animals

1992 • 55 citations

Food intake of lean and obese Zucker rats following ventricular infusions of adrenergic agonists

1992 • 52 citations

Isoproterenol response following transfection of the mouse beta 2-adrenergic receptor gene into Y1 cells.

1988 • 48 citations

ICI D7114: a novel selective adrenoceptor agonist of brown fat and thermogenesis

1992 • 43 citations

A response to isoprenaline unrelated to α‐and β‐adrenoceptor agonism

1987 • 39 citations

The antidiabetic β3-adrenoceptor agonist BRL 26830A works by release of endogenous insulin

1992 • 32 citations

Presence of a functional inhibitory GTP-binding regulatory component, Gi, linked to adenylate cyclase in adipocytes of ob/ob mice.

1987 • 18 citations

Characterization of a Mouse β₁-Adrenergic Receptor Genomic Clone

1993 • 17 citations

Adrenergic Receptor Subtypes: Pharmacological Approaches

1994 • 3 citations