Administration of two macrophage-derived interferon-γ-inducing factors (IL-12 and IL-15) induces a lethal systemic inflammatory response in mice that is dependent on natural killer cells but does not require interferon-γ

CELLULAR RESPONSES TO INTERFERON-γ

1997 • 2,885 citations

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

1994 • 1,772 citations

Multiple Defects of Immune Cell Function in Mice with Disrupted Interferon-γ Genes

1993 • 1,753 citations

The Instructive Role of Innate Immunity in the Acquired Immune Response

1996 • 1,731 citations

Targeted Disruption of the Mouse Stat1 Gene Results in Compromised Innate Immunity to Viral Disease

1996 • 1,560 citations

Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice

1996 • 1,277 citations

THE INTERLEUKIN-12/INTERLEUKIN-12-RECEPTOR SYSTEM: Role in Normal and Pathologic Immune Responses

1998 • 1,253 citations

Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

1996 • 1,182 citations

Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor.

1994 • 1,079 citations

Biology and clinical relevance of human natural killer cells

1990 • 930 citations

Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts.

1993 • 837 citations

Effects of Single-Dose Interleukin-12 Exposure on Interleukin-12–Associated Toxicity and Interferon-γ Production

1997 • 788 citations

TNF Receptor-Deficient Mice Reveal Divergent Roles for p55 and p75 in Several Models of Inflammation

1998 • 715 citations

Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4.

1995 • 675 citations

Differential Cytokine and Chemokine Gene Expression by Human NK Cells Following Activation with IL-18 or IL-15 in Combination with IL-12: Implications for the Innate Immune Response

1999 • 644 citations

Activation and function of natural killer cell responses during viral infections

1997 • 430 citations

Tyrosine phosphorylation and activation of STAT5, STAT3, and Janus kinases by interleukins 2 and 15.

1995 • 397 citations

Endogenous production of interleukin 15 by activated human monocytes is critical for optimal production of interferon-gamma by natural killer cells in vitro.

1995 • 357 citations

Cytokines acting on or secreted by macrophages during intracellular infection (IL-10, IL-12, IFN-γ)

1997 • 349 citations

The liver as a crucial organ in the first line of host defense: the roles of Kupffer cells, natural killer (NK) cells and NK1.1 Ag+ T cells in T helper 1 immune responses

2000 • 339 citations

Role of Cytokines in Sepsis

1997 • 293 citations

T Cell–mediated Pathology in Two Models of Experimental Colitis Depends Predominantly on the Interleukin 12/Signal Transducer and Activator of Transcription (Stat)-4 Pathway, but Is Not Conditional on Interferon γ Expression by T Cells

1998 • 288 citations

Signaling pathways activated by interferons

1999 • 268 citations

IL-18 (IFN-gamma-inducing factor) regulates early cytokine production in, and promotes resolution of, bacterial infection in mice.

1998 • 238 citations

A block in both early T lymphocyte and natural killer cell development in transgenic mice with high-copy numbers of the human CD3E gene.

1994 • 233 citations

Role of CD14 in Cellular Recognition of Bacterial Lipopolysaccharides

1999 • 201 citations

IL-18 (IFN-γ-Inducing Factor) Regulates Early Cytokine Production in, and Promotes Resolution of, Bacterial Infection in Mice

1998 • 195 citations

Cytokines as Mediators in the Pathogenesis of Septic Shock

1996 • 176 citations

Production of IL-5 by human NK cells and regulation of IL-5 secretion by IL-4, IL-10, and IL-12.

1995 • 168 citations

IL-13 production by NK cells: IL-13-producing NK and T cells are present in vivo in the absence of IFN-gamma.

1999 • 150 citations

Elevated Plasma Concentrations of Interferon (IFN)–γ and the IFN‐γ–Inducing Cytokines Interleukin (IL)–18, IL‐12, and IL‐15 in Severe Melioidosis

1999 • 144 citations

IL-13 Production by NK Cells: IL-13-Producing NK and T Cells Are Present In Vivo in the Absence of IFN-γ

1999 • 122 citations

Interleukin 1 participates in the development of anti-Listeria responses in normal and SCID mice.

1992 • 110 citations

Pivotal Role of Signal Transducer and Activator of Transcription (Stat)4 and Stat6 in the Innate Immune Response during Sepsis

2001 • 106 citations

Coadministration of interleukin-18 and interleukin-12 induces a fatal inflammatory response in mice: critical role of natural killer cell interferon-γ production and STAT-mediated signal transduction

2000 • 103 citations

A Fatal Cytokine-Induced Systemic Inflammatory Response Reveals a Critical Role for NK Cells

1999 • 101 citations

Cytokines and inflammation

1992 • 101 citations

Differential utilization of Janus kinase-signal transducer activator of transcription signaling pathways in the stimulation of human natural killer cells by IL-2, IL-12, and IFN-alpha.

1996 • 96 citations

Localization of pro-inflammatory (IL-12, IL-15) and anti-inflammatory (IL-11, IL-13) cytokines at the foetomaternal interface during murine pregnancy

2001 • 89 citations

Altered Interleukin-12 Responsiveness in Th1 and Th2 Cells Is Associated With the Differential Activation of STAT5 and STAT1

1998 • 78 citations

Cytokine cross‐talk between phagocytic cells and lymphocytes: Relevance for differentiation/activation of phagocytic cells and regulation of adaptive immunity

1993 • 72 citations

Transforming growth factor-beta expression and natural killer cell responses during virus infection of normal, nude, and SCID mice.

1993 • 72 citations

The effect of interleukin 12 desensitization on the antitumor efficacy of recombinant interleukin 12.

1997 • 69 citations

The Regulation and Biological Activity of Interleukin 12

1998 • 69 citations

Effect of corticosteroid on the antitumor activity of lymphokine-activated killer cells and interleukin 2 in mice.

1986 • 67 citations

Low-dose interleukin 2 prevents the development of Epstein-Barr virus (EBV)-associated lymphoproliferative disease in scid/scid mice reconstituted i.p. with EBV-seropositive human peripheral blood lymphocytes.

1994 • 67 citations

Cytokines and inflammation

2015 • 63 citations

Cutting Edge: IL-15 Costimulates the Generalized Shwartzman Reaction and Innate Immune IFN-γ Production In Vivo

2000 • 60 citations

The cytokine factsbook

1994 • 60 citations

The Physiologic Basis for Anticytokine Clinical Trials in the Treatment of Sepsis 1

1998 • 58 citations

Protective Effect of a Single Interleukin-12 (IL-12) Predose Against the Toxicity of Subsequent Chronic IL-12 in Mice: Role of Cytokines and Glucocorticoids

1997 • 39 citations

Secretion of cytokines by natural killer cells primed with interleukin‐2 and stimulated with different lipoproteins

1997 • 37 citations

TGF-beta mediates natural suppressor activity of IL-2-activated lymphocytes.

1994 • 34 citations

β-Catenin Expression Enhances IL-7 Receptor Signaling in Thymocytes during Positive Selection

2007 • 31 citations

Design of clinical trials in sepsis: problems and pitfalls

1998 • 26 citations

Cytokines are critical in linking the innate and adaptive immune responses to bacterial, fungal, and parasitic infection.

1999 • 26 citations

Ibuprofen Causes Reduced Toxic Effects of Interleukin 2 Administration in Patients With Metastatic Cancer

1989 • 25 citations

Natural Killer Cells and Their Precursors in Mice With Severe Combined Immunodeficiency

1989 • 24 citations

Interleukin 15: A Potential Player during the Innate Immune Response to Infection

1996 • 16 citations