Modifications of Cell Signalling in the Cytotoxicity of Metals

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

1976 • 5,526 citations

INOSITOL TRISPHOSPHATE AND DIACYLGLYCEROL: TWO INTERACTING SECOND MESSENGERS

1987 • 3,302 citations

INTRACELLULAR CALCIUM HOMEOSTASIS

1987 • 2,183 citations

Programmed cell death involved in the schizolysigenous formation of the secretory cavity in Citrus sinensis L. (Osbeck)

2010 • 1,629 citations

Calcium channel modulation by neurotransmitters, enzymes and drugs

1983 • 1,267 citations

Repetitive transient rises in cytoplasmic free calcium in hormone-stimulated hepatocytes

1986 • 790 citations

The function and structure of the metal coordination sites within the glucocorticoid receptor DNA binding domain

1988 • 522 citations

Calcium oscillations.

1990 • 520 citations

Picomolar concentrations of lead stimulate brain protein kinase C

1988 • 442 citations

Inositol 1,4,5-trisphosphate receptor localized to endoplasmic reticulum in cerebellar Purkinje neurons

1989 • 431 citations

Role of Ca2+ channels in the ability of membrane depolarization to prevent neuronal death induced by trophic-factor deprivation: evidence that levels of internal Ca2+ determine nerve growth factor dependence of sympathetic ganglion cells.

1989 • 405 citations

Calcium content of mitochondria and endoplasmic reticulum in liver frozen rapidly in vivo

1985 • 356 citations

Regulation of the differentiation of PC12 pheochromocytoma cells.

1989 • 296 citations

ATP stimulates Ca2+ uptake and increases the free Ca2+ concentration in isolated rat liver nuclei.

1989 • 284 citations

Cadmium uptake and toxicity via voltage-sensitive calcium channels.

1987 • 282 citations

2,5-Di-(tert-butyl)-1,4-benzohydroquinone rapidly elevates cytosolic Ca2+ concentration by mobilizing the inositol 1,4,5-trisphosphate-sensitive Ca2+ pool

1989 • 261 citations

Cadmium evokes inositol polyphosphate formation and calcium mobilization

1989 • 212 citations

Mercury concentrations in the human brain and kidneys in relation to exposure from dental amalgam fillings.

1987 • 205 citations

The role of calcium in cell killing

1990 • 199 citations

Biological aspects of metals and metal-related diseases

1983 • 198 citations

Zinc can increase the activity of protein kinase C and contributes to its binding to plasma membranes in T lymphocytes.

1988 • 189 citations

Characterization of inositol 1,4,5-trisphosphate receptors and calcium mobilization in a hepatic plasma membrane fraction.

1988 • 178 citations

An inositol 1,4,5-trisphosphate-sensitive Ca2+ pool in liver nuclei.

1990 • 165 citations

A kinetic analysis of the effects of adrenaline on calcium distribution in isolated rat liver parenchymal cells

1981 • 136 citations

Increased free intrasynaptosomal Ca2+ by neurotoxic organometals: Distinctive mechanisms

1987 • 126 citations

Growth and Differentiation of Neural Cells in Defined Media

1985 • 117 citations

Accumulation of methylmercury and inorganic mercury in the brain

1989 • 116 citations

Receptor-mediated calcium influx in PC12 cells. ATP and bradykinin activate two independent pathways

1990 • 115 citations

Cadmium Inhibition of the Erythrocyte Ca2+ Pump

1989 • 107 citations

Dose-Dependence of Methylmercury Metabolism

1975 • 103 citations

The Prediction Of Intake Of Mercury Vapor from Amalgams

1988 • 103 citations

Cytosolic‐free Ca ²⁺ and cell killing in hepatoma 1c1c7 cells exposed to chemical anoxia

1989 • 102 citations

Evidence for the involvement of dithiol groups in mitochondrial calcium transport: Studies with cadmium

1985 • 102 citations

The Transport of Elemental Mercury into Fetal Tissues

1972 • 87 citations

Hg2+ causes neurotoxicity at an intracellular site following entry through Na and Ca channels

1983 • 80 citations

Inhibition of Phorbol Ester Binding and Protein Kinase C Activity by Heavy Metals

1989 • 68 citations

Increased free intracellular Ca2+ by toxic agents: an index of potential neurotoxicity?

1988 • 65 citations

Phorbol ester stimulates proliferation of astrocytes in primary culture

1987 • 61 citations

Why do neurons die when deprived of trophic factor?

1989 • 57 citations

Calcium metabolism in aluminum encephalopathy

1985 • 57 citations

Methylmercury inhibition of rat brain muscarinic receptors

1980 • 55 citations

Chronic toxicity of methylmercury in the adult cat interim report

1976 • 55 citations

Alterations in inositol phosphate production during oxidative stress in isolated hepatocytes.

1987 • 53 citations

The inhibition of cerebral high affinity receptor sites by lead and mercury compounds

1980 • 53 citations

Experimental Methyl Mercury Neurotoxicity: Locus of Mercurial Inhibition of Brain Protein Synthesis In Vivo and In Vitro

1985 • 52 citations

Inhibition of the liver cell receptor-activated Ca2+ inflow system by metal ion inhibitors of voltage-operated Ca2+ channels but not by other inhibitors of Ca2+ inflow

1989 • 48 citations

Effects of cadmium on lymphocyte activation

1989 • 47 citations

Cells without growth factors commit suicide

1988 • 37 citations

Changes in protein and RNA synthesis in rat brain neurons after a single dose of methylmercury

1982 • 36 citations

Cerebellar Calification: A Possible Marker of Lead Poisoning

1977 • 32 citations

Action of Mercurials on Activity of Partially Purified Soluble Protein Kinase C from Mice Brain

1988 • 31 citations

Activation of the EGF receptor tyrosine kinase by divalent metal ions: Comparison of holoreceptor and isolated kinase domain properties

1990 • 29 citations

Deleted Work

1955 • 0 citations