Mapping of the minimal domain encoding a conformational epitope by λ phage surface display: factor VIII inhibitor antibodies from haemophilia A patients

Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase

1988 • 17,059 citations

Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mpl8 and pUC19 vectors

1985 • 15,222 citations

Enzyme-linked immunosorbent assay (ELISA) quantitative assay of immunoglobulin G

1971 • 3,630 citations

Light-Directed, Spatially Addressable Parallel Chemical Synthesis

1991 • 2,692 citations

Searching for Peptide Ligands with an Epitope Library

1990 • 2,080 citations

Three-Dimensional Structure of an Antigen-Antibody Complex at 2.8 Å Resolution

1986 • 1,173 citations

Molecular cloning of a cDNA encoding human antihaemophilic factor

1984 • 937 citations

Structure of human factor VIII

1984 • 898 citations

Strategies for epitope analysis using peptide synthesis

1987 • 887 citations

Expression of active human factor VIII from recombinant DNA clones

1984 • 699 citations

Incidence of development of factor VIII and factor IX inhibitors in haemophiliacs

1992 • 613 citations

The role of phospholipid and factor VIIIa in the activation of bovine factor X.

1981 • 590 citations

Interactions of protein antigens with antibodies.

1996 • 543 citations

Mutations that Allow Disulfide Bond Formation in the Cytoplasm of Escherichia coli

1993 • 420 citations

Mutagenic PCR.

1994 • 298 citations

Efficient mapping of protein antigenic determinants.

1986 • 292 citations

Mimicking of discontinuous epitopes by phage-displayed peptides, I. Epitope mapping of human H ferritin using a phage library of constrained peptides

1993 • 235 citations

Human factor VIIIa subunit structure. Reconstruction of factor VIIIa from the isolated A1/A3-C1-C2 dimer and A2 subunit

1991 • 217 citations

High resolution functional analysis of antibody-antigen interactions

1992 • 213 citations

A Factor VIII Neutralizing Monoclonal Antibody and a Human Inhibitor Alloantibody Recognizing Epitopes in the C2 Domain Inhibit Factor VIII Binding to von Willebrand Factor and to Phosphatidylserine

1993 • 199 citations

Synthetic factor VIII peptides with amino acid sequences contained within the C2 domain of factor VIII inhibit factor VIII binding to phosphatidylserine

1990 • 198 citations

The Acidic Region of the Factor VIII Light Chain and the C2 Domain Together Form the High Affinity Binding Site for von Willebrand Factor

1997 • 196 citations

An Antibody Binding Site on Cytochrome C Defined by Hydrogen Exchange and Two-Dimensional NMR

1990 • 187 citations

Molecular basis of factor VIII inhibition by human antibodies. Antibodies that bind to the factor VIII light chain prevent the interaction of factor VIII with phospholipid.

1989 • 183 citations

Some factor VIII inhibitor antibodies recognize a common epitope corresponding to C2 domain amino acids 2248 through 2312, which overlap a phospholipid-binding site

1995 • 181 citations

Display of peptides and proteins on the surface of bacteriophage lambda.

1995 • 181 citations

The Inhibitor Antibody Response Is More Complex in Hemophilia A Patients Than in Most Nonhemophiliacs With Factor VIII Autoantibodies

1997 • 180 citations

FVIII inhibitor IgG subclass and FVIII polypeptide specificity determined by immunoblotting

1987 • 158 citations

Lambda foo: a lambda phage vector for the expression of foreign proteins.

1994 • 140 citations

Role of Capsid Structure and Membrane Protein Processing in Determining the Size and Copy Number of Peptides Displayed on the Major Coat Protein of Filamentous Bacteriophage

1996 • 137 citations

Residues 484-508 Contain a Major Determinant of the Inhibitory Epitope in the A2 Domain of Human Factor VIII

1995 • 137 citations

Surface Display of Proteins on Bacteriophage λ Heads

1996 • 134 citations

Localization of epitopes for human factor VIII inhibitor antibodies by immunoblotting and antibody neutralization

1989 • 130 citations

Identification of biologically active peptides using random libraries displayed on phage

1995 • 119 citations

Eficient display of an HCV cDNA expression library as C-terminal fusion to the capsid protein D of bacteriophage lambda

1998 • 100 citations

A Mechanism for Inhibition of Factor VIII Binding to Phospholipid by von Willebrand Factor

1995 • 97 citations

Some Human Inhibitor Antibodies Interfere With Factor VIII Binding to Factor IX

1998 • 94 citations

Epitope mapping by phage display: Random versus gene-fragment libraries

1997 • 91 citations

Use of a gene-targeted phage display random epitope library to map an antigenic determinant on the bluetongue virus outer capsid protein VP5

1995 • 83 citations

Display of peptides and proteins on the surface of bacteriophage λ

1995 • 76 citations

The Canine Factor VIII cDNA and 5’ Flanking Sequence

1998 • 75 citations

Locations of disulfide bonds and free cysteines in the heavy and light chains of recombinant human factor VIII (antihemophilic factor A)

1995 • 71 citations

Common inhibitory effects of human anti‐C2 domain inhibitor alloantibodies on factor VIII binding to von Willebrand factor

1995 • 69 citations

Mapping of linear epitopes recognized by monoclonal antibodies with gene-fragment phage display libraries

1995 • 67 citations

Assembly of Functional Bacteriophage Lambda Virions Incorporating C-Terminal Peptide or Protein Fusions with the Major Tail Protein

1995 • 56 citations

A Human Alloantibody Interferes With Binding of Factor IXa to the Factor VIII Light Chain

1998 • 53 citations

A Soluble Recombinant Factor VIII Fragment Containing the A2 Domain Binds to Some Human Anti-Factor VIII Antibodies that Are not Detected by Immunoblotting

1992 • 51 citations

Analysis of the Human Factor VIII A2 Inhibitor Epitope by Alanine Scanning Mutagenesis

1997 • 47 citations

A Model for Transmembrane Signalling by the Aspartate Receptor Based on Random-cassette Mutagenesis and Site-directed Disulphide Cross-linking

1995 • 46 citations

A Human Alloantibody Interferes With Binding of Factor IXa to the Factor VIII Light Chain

1998 • 46 citations

Identification of functional interaction sites on proteins using bacteriophage-displayed random epitope libraries

1995 • 44 citations

Efficient epitope mapping by bacteriophage λ surface display

1997 • 36 citations

NMR Mapping of the Antigenic Determinant Recognized by an Anti-Gp120, Human Immunodeficiency Virus Neutralizing Antibody

1995 • 31 citations

NMR Mapping of the Antigenic Determinant Recognized by an Anti-Gp120, Human Immunodeficiency Virus Neutralizing Antibody

1995 • 28 citations

Epitope mapping by negative selection of randomized antigen libraries displayed on filamentous phage 1 1Edited by J. Karn

1997 • 24 citations

Epitope mapping of human factor VIII inhibitor antibodies by site-directed mutagenesis of a factor VIII polypeptide

1992 • 22 citations

Characterization of a factor VIII immunogenic site using factor VIII synthetic peptide 1687–1695 and rabbit anti-peptide antibodies

1992 • 13 citations

Tea Bag Synthesis of Positional Scanning Synthetic Combinatorial Libraries and Their Use for Mapping Antigenic Determinants

2003 • 12 citations

Epitope mapping and serodiagnosis using Ata- and (Lys)7 peptides

1998 • 4 citations