Nociceptin/Orphanin FQ Metabolism: Role of Aminopeptidase and Endopeptidase 24.15

The Rat Brain in Stereotaxic Coordinates

1982 • 53,055 citations

Solid Phase Peptide Synthesis. I. The Synthesis of a Tetrapeptide

1963 • 7,266 citations

Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor

1995 • 1,887 citations

Orphanin FQ: A Neuropeptide That Activates an Opioidlike G Protein-Coupled Receptor

1995 • 1,800 citations

ORL1, a novel member of the opioid receptor family

1994 • 1,060 citations

Neutral endopeptidase 24.11: structure, inhibition, and experimental and clinical pharmacology.

1993 • 734 citations

Bestatin, an inhibitor of aminopeptidase B, produced by actinomycetes.

1976 • 706 citations

High-affinity enkephalin-degrading peptidase in brain is increased after morphine

1978 • 652 citations

Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family that is not a μ, δ or κ opioid receptor type

1994 • 593 citations

cDNA Cloning of an orphan opiate receptor gene family member and its splice variant

1994 • 379 citations

Molecular cloning, tissue distribution and chromosomal localization of a novel member of the opioid receptor gene family

1994 • 333 citations

A soluble metalloendopeptidase from rat brain

1983 • 270 citations

Molecular Cloning of a Novel G Protein‐Coupled Receptor Related to the Opiate Receptor Family

1995 • 249 citations

Complete amino acid sequence of human intestinal aminopeptidase N as deduced from cloned cDNA

1988 • 241 citations

Increase by the ORL₁ receptor (opioid receptor‐like₁) ligand, nociceptin, of inwardly rectifying K conductance in dorsal raphe nucleus neurones

1996 • 231 citations

Autoradiographic comparison of the distribution of the neutral endopeptidase "enkephalinase" and of mu and delta opioid receptors in rat brain.

1986 • 206 citations

Amino Acid Sequence Deduced from a Rat Kidney cDNA Suggests It Encodes the Zn-Peptidase Aminopeptidase N

1989 • 116 citations

Development of Highly Potent and Selective Phosphinic Peptide Inhibitors of Zinc Endopeptidase 24-15 Using Combinatorial Chemistry

1995 • 107 citations

In vitro and in vivo effects of kelatorphan on enkephalin metabolism in rodent brain

1985 • 87 citations

Potent and systemically active aminopeptidase N inhibitors designed from active-site investigation

1992 • 87 citations

Complete differentiation between enkephalinase and angiotensin-converting enzyme inhibition by retro-thiorphan.

1983 • 86 citations

Endopeptidases 24.16 and 24.15 Are Responsible for the Degradation of Somatostatin, Neurotensin, and Other Neuropeptides by Cultivated Rat Cortical Astrocytes

1994 • 84 citations

Inhibitory potency of various peptides on enkephalinase activity from mouse striatum

1979 • 71 citations

The degradation of dynorphin A in brain tissue in vivo and in vitro

1987 • 63 citations

Enkephalin Metabolism by Microglia Aminopeptidase N (CD13)

1995 • 61 citations

Neurotensin metabolism in various tissues of central and peripheral origins: ubiquitous involvement of a novel neurotensin degrading metalloendopeptidase

1988 • 54 citations

Endopeptidase‐24.11 Is the Integral Membrane Peptidase Initiating Degradation of Somatostatin in the Hippocampus

1995 • 53 citations

Degradation of Dynorphin‐Related Peptides by the Puromycin‐Sensitive Aminopeptidase and Aminopeptidase M

1995 • 52 citations

Identification of Dynorphins as Endogenous Ligands for an Opioid Receptor-like Orphan Receptor

1995 • 49 citations

Enkephalin Degrading Enzyme Inhibitors: A Physiological Way to New Analgesics and Psychoactive Agents

1986 • 48 citations

An Inhibitor of Endopeptidase‐24.15 Blocks the Degradation of Intraventricularly Administered Dynorphins

1990 • 45 citations

Metabolism of opioid peptides by cerebral microvascular aminopeptidase M

1987 • 43 citations

Rabbit liver microsomal endopeptidase with substrate specificity for processing proproteins is structurally related to rat testes metalloendopeptidase 24.15

1993 • 34 citations

Phosphorus‐containing peptides as mixed inhibitors of endopeptidase 3.4.24.15 and 3.4.24.16: effect on neurotensin degradation in vitro and in vivo

1995 • 33 citations

Cholecystokinin octa- and tetrapeptide degradation by synaptic membranes. I. Evidence for competition with enkephalins for in vitro common degradation pathways

1981 • 33 citations

Retro-inverso concept applied to the complete inhibitors of enkephalin-degrading enzymes

1988 • 33 citations

Charge polarity reversal inverses the specificity of neutral endopeptidase-24.11.

1992 • 28 citations

Antinociceptive properties of inhibitors of endopeptidase 24.15

1991 • 21 citations

Purification and Characterization of a Secreted Arginine-Specific Dibasic Cleaving Enzyme from EL-4 Cells

1995 • 19 citations

Neuropeptide metabolism on intact, regional brain slices: effect of dopaminergic agents on substance P, cholecystokinin and Met-enkephalin degradation.

1995 • 12 citations

Inhibitors of the enkephalin degrading enzymes Modulation of activity of hydroxamate containing compounds by modifications of the C‐terminal residue

1989 • 12 citations

Physiological role of endogenous peptide effectors studied with peptidase inhibitors.

1988 • 9 citations

MOLECULAR CLONING OF ENDOPEPTIDASE-24.15 FROM PIG BRAIN

1994 • 2 citations