Recognition and activation of the opioid receptor-like ORL1 receptor by nociceptin, nociceptin analogs and opioids

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor

1995 • 1,887 citations

Orphanin FQ: A Neuropeptide That Activates an Opioidlike G Protein-Coupled Receptor

1995 • 1,800 citations

ORL1, a novel member of the opioid receptor family

1994 • 1,060 citations

Pharmacological characterization of the cloned kappa-, delta-, and mu-opioid receptors.

1994 • 630 citations

Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family that is not a μ, δ or κ opioid receptor type

1994 • 593 citations

Opiate Agonists and Antagonists Discriminated by Receptor Binding in Brain

1973 • 527 citations

Specific receptor for the opioid peptide dynorphin: structure--activity relationships.

1981 • 411 citations

cDNA cloning and regional distribution of a novel member of the opioid receptor family

1994 • 404 citations

cDNA Cloning of an orphan opiate receptor gene family member and its splice variant

1994 • 379 citations

Molecular cloning, tissue distribution and chromosomal localization of a novel member of the opioid receptor gene family

1994 • 333 citations

Immunohistochemical localization of ORL-1 in the central nervous system of the rat

1996 • 283 citations

An aspartate conserved among G-protein receptors confers allosteric regulation of alpha 2-adrenergic receptors by sodium.

1990 • 266 citations

The cloned μ, δ and κ receptors and their endogenous ligands: Evidence for two opioid peptide recognition cores

1995 • 263 citations

Isolation of a novel cDNA encoding a putative membrane receptor with high homology to the cloned μ, δ, and κ opioid receptors

1994 • 254 citations

Molecular Cloning of a Novel G Protein‐Coupled Receptor Related to the Opiate Receptor Family

1995 • 249 citations

Structure-Activity Relationship Studies on the Novel Neuropeptide Orphanin FQ

1996 • 196 citations

Orphanin FQ: Receptor binding and analog structure activity relationships in rat brain

1996 • 147 citations

A single residue, aspartic acid 95, in the delta opioid receptor specifies selective high affinity agonist binding.

1993 • 146 citations

Nociceptin stimulates locomotion and exploratory behaviour in mice

1996 • 140 citations

Structure and Chromosomal Mapping of Genes for the Mouse κ-Opioid Receptor and an Opioid Receptor Homologue (MOR-C)

1994 • 116 citations

A separation method for the assay of adenylylcyclase, intracellular cyclic AMP, and cyclic-AMP phosphodiesterase using tritium-labeled substrates

1992 • 67 citations

Mutation of an aspartate at residue 89 in somatostatin receptor subtype 2 prevents Na+ regulation of agonist binding but does not alter receptor-G protein association.

1993 • 64 citations

Na+ ions and Gpp(NH)p selectively inhibit agonist interactions at μ- and κ-opioid receptor sites in rabbit and guinea-pig cerebellum membranes

1985 • 57 citations

Replacement of Gln²⁸⁰ by His in TM6 of the human ORL1 receptor increases affinity but reduces intrinsic activity of opioids

1996 • 44 citations

Pronociceptive effects of the neuropeptide, nociceptin, in the land snail, Cepaea nemoralis

1996 • 32 citations