Nitrate tolerance, rebound, and their clinical relevance in stable angina pectoris, unstable angina, and heart failure

A Comparison of Enalapril with Hydralazine–Isosorbide Dinitrate in the Treatment of Chronic Congestive Heart Failure

1991 • 2,867 citations

Effect of Vasodilator Therapy on Mortality in Chronic Congestive Heart Failure

1986 • 2,409 citations

Plaque fissuring--the cause of acute myocardial infarction, sudden ischaemic death, and crescendo angina.

1985 • 2,003 citations

Evidence for enhanced vascular superoxide anion production in nitrate tolerance. A novel mechanism underlying tolerance and cross-tolerance.

1995 • 660 citations

Mechanism of tolerance development to organic nitrates.

1973 • 486 citations

Prevention and Reversal of Nitrate Tolerance in Patients with Congestive Heart Failure

1987 • 366 citations

Oral Isosorbide dinitrate in angina pectoris: Comparison of duration of action and dose-response relation during acute and sustained therapy

1982 • 303 citations

Improved exercise capacity and differing arterial and venous tolerance during chronic isosorbide dinitrate therapy for congestive heart failure.

1983 • 295 citations

Trainsdermal nitroglycerin in angina pectoris

1984 • 257 citations

Organic nitrate esters: clinical use and mechanisms of actions.

1991 • 234 citations

Effect of Intervals between Doses on the Development of Tolerance to Isosorbide Dinitrate

1987 • 218 citations

Tolerance to intravenous nitroglycerin in patients with congestive heart failure: Role of increased intravascular volume, neurohumoral activation and lack of prevention with N-acetylcysteine

1990 • 211 citations

Tolerance to the circulatory effects of oral isosorbide dinitrate. Rate of development and cross-tolerance to glyceryl trinitrate.

1980 • 196 citations

Intermittent transdermal nitroglycerin therapy in the treatment of chronic stable angina

1989 • 190 citations

Platelets, vasoconstriction, and nitroglycerin during arterial wall injury. A new antithrombotic role for an old drug.

1988 • 152 citations

Tolerance to Organic Nitrates: Evidence, Mechanisms, Clinical Relevance, and Strategies for Prevention

1991 • 151 citations

Intravenous nitroglycerin infusion inhibits cyclic blood flow responses caused by periodic platelet thrombus formation in stenosed canine coronary arteries.

1991 • 146 citations

Prevention of tolerance to hemodynamic effects of nitrates with concomitant use of hydralazine in patients with chronic heart failure

1995 • 140 citations

Effects of nitroglycerin at therapeutic doses on platelet aggregation in unstable angina pectoris and acute myocardial infarction

1990 • 137 citations

Antianginal effects of intravenous nitroglycerin over 24 hours.

1988 • 129 citations

Isosorbide Dinitrate

1975 • 122 citations

Tolerance to the vascular effects of glyceryl trinitrate.

1970 • 119 citations

A study of cross-tolerance to circulatory effects of organic nitrates

1967 • 113 citations

Intravenous nitroglycerin in the treatment of spontaneous angina pectoris: a prospective, randomized trial.

1983 • 113 citations

Efficacy and safety of extended-release isosorbide mononitrate for stable effort angina pectoris

1993 • 113 citations

Concurrent hydralazine administration prevents nitroglycerin-induced hemodynamic tolerance in experimental heart failure.

1991 • 112 citations

Oral isosorbide dinitrate in the treatment of angina pectoris. Dose-response relationship and duration of action during acute therapy.

1980 • 111 citations

Nitrate tolerance and dependence

1980 • 109 citations

Mechanisms of nitrate tolerance

1994 • 100 citations

Nitrate tolerance: the lack of effect of N-acetylcysteine.

1987 • 97 citations

ACQUIRED TOLERANCE TO AND CROSS TOLERANCE BETWEEN THE NITROUS AND NITRIC ACID ESTERS AND SODIUM NITRITE IN MAN

1931 • 90 citations

Acute and chronic antianginal efficacy of continuous twenty-four-hour application of transdermal nitroglycerin

1991 • 89 citations

Altered spectrum of nitroglycerin action in long-term treatment: nitroglycerin-specific venous tolerance with maintenance of arterial vasodepressor potency.

1986 • 82 citations

Tolerance development during isosorbide dinitrate treatment: can it be circumvented?

1983 • 79 citations

Failure of captopril to prevent nitrate tolerance in congestive heart failure secondary to coronary artery disease

1990 • 72 citations

Dissociation of coronary vascular tolerance and neurohormonal adjustments during long-term nitroglycerin therapy in patients with stable coronary artery disease

1996 • 68 citations

TOLERANCE TO NITROGLYCERIN.

1905 • 66 citations

[Condition following myocardial infarct: which studies at what time and with what patients?].

1983 • 64 citations

The Cause, Relief and Prevention of Headaches Arising from Contact with Dynamite

1946 • 61 citations

Lack of Pharmacologic Tolerance and Rebound Angina Pectoris during Twice-Daily Therapy with Isosorbide-5-Mononitrate

1994 • 59 citations

Eccentric dosing with isosorbide-5-mononitrate in angina pectoris

1993 • 58 citations

Tolerance towards glyceryl trinitrate (trinitrin) in dogs.

1968 • 55 citations

Biochemical characterization of a membrane-bound enzyme responsible for generating nitric oxide from nitroglycerin in vascular smooth muscle cells

1993 • 54 citations

Nitroglycerin and long-acting nitrates in clinical practice

1983 • 52 citations

Short and long-acting oral nitrates for stable angina pectoris

1994 • 52 citations

Effects of diuretic therapy on the development of tolerance during continuous therapy with nitroglycerin

1992 • 45 citations

Isosorbide dinitrate and glyceryl trinitrate: Demonstration of cross tolerance in the capacitance vessels

1985 • 45 citations

Nonocclusive coronary disease after chronic exposure to nitrates: Evidence for physiologic nitrate dependence

1975 • 45 citations

Different susceptibility to the development of nitroglycerin tolerance in the arterial and venous circulation in humans. Effects of N-acetylcysteine administration.

1992 • 38 citations

Dose dependence of tolerance during treatment with mononitrates.

1983 • 37 citations

The daylong pattern of the antianginal effect of long-term three times daily administered isosorbide dinitrate

1990 • 37 citations

Occupational habituation to aliphatic nitrates and the withdrawal hazards of coronary disease and hypertension.

1977 • 34 citations

Nitrate therapy for myocardial ischemic syndromes: Current perspectives including tolerance

1988 • 34 citations

Ointments and transdermal nitroglycerin patches for stable angina pectoris

1994 • 32 citations

Mechanisms of nitrate action and vascular tolerance

1989 • 28 citations

Nitrates for unstable angina

1994 • 28 citations

Absence of vascular tolerance in conductance vessels after 48 hours of intravenous nitroglycerin in patients with coronary artery disease

1995 • 22 citations

Efficacy of continuous and intermittent transdermal treatment with nitroglycerin in effort angina pectoris: a multicentric study

1991 • 21 citations

Effects of 8:00 A.M. and 2:00 P.M. Doses of isosorbide-5-mononitrate during twice-daily therapy in stable angina pectoris

1992 • 20 citations

Nitrate tolerance in heart failure: Differential venous, pulmonary and systemic arterial effects

1990 • 17 citations

Effects of continuous intravenous infusion of isosorbide dinitrate on development of tolerance to vasodilating action in human epicardial coronary arteries

1994 • 15 citations

Lack of rebound during intermittent transdermal treatment with glyceryl trinitrate in patients with stable angina on background beta blocker.

1993 • 12 citations

Effect of intermittent exposure and drug-free intervals on the vascular tolerance to nitroglycerin

1989 • 11 citations