Nitrate therapy for myocardial ischemic syndromes: Current perspectives including tolerance
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Abstract
References (222)
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Oral Isosorbide dinitrate in angina pectoris: Comparison of duration of action and dose-response relation during acute and sustained therapy
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1980 • 302 citations
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1983 • 295 citations
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1959 • 291 citations
Effect of nitrates and other coronary dilators on large and small coronary vessels: an hypothesis for the mechanism of action of nitrates.
1969 • 268 citations
Nonatheromatous Ischemic Heart Disease following Withdrawal from Chronic Industrial Nitroglycerin Exposure
1972 • 260 citations
Trainsdermal nitroglycerin in angina pectoris
1984 • 257 citations
Hemodynamic Effects of Orally Administered Isosorbide Dinitrate in Patients with Congestive Heart Failure
1974 • 247 citations
Use of Sublingual Nitroglycerin in Congestive Failure following Acute Myocardial Infarction
1972 • 240 citations
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1987 • 233 citations
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1972 • 220 citations
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1984 • 220 citations
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1987 • 218 citations
NITRO-GLYCERINE AS A REMEDY FOR ANGINA PECTORIS.
1879 • 215 citations
Antianginal effects of nitroglycerin patches
1984 • 210 citations
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1980 • 196 citations
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1983 • 192 citations
Double-blind Evaluation of Verapamil, Propranolol, and Isosorbide Dinitrate against a Placebo in the Treatment of Angina Pectoris
1973 • 188 citations
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1974 • 187 citations
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1985 • 180 citations
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Reduction of CK and CK-MB indexes of infarct size by intravenous nitroglycerin.
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Clinical and Circulatory Effects of Isosorbide Dinitrate
1971 • 174 citations
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1980 • 173 citations
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Magnitude of dilatation of large and small coronary arteries of nitroglycerin.
1981 • 169 citations
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1987 • 169 citations
Nitroglycerin-induced severe hypotension and bradycardia in patients with acute myocardial infarction.
1976 • 158 citations
Site of increased resistance to coronary flow in patients with angina pectoris and normal epicardial coronary arteries
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1937 • 153 citations
Blood levels after sublingual nitroglycerin.
1979 • 153 citations
Effect of nitroglycerin on exercise-induced abnormalities of left ventricular regional function and ejection fraction in coronary artery disease. Assessment by radionuclide clineagiography in symptomatic and asymptomatic patients.
1978 • 152 citations
Effects of Nitroglycerin on Regional Myocardial Blood Flow in Coronary Artery Disease
1971 • 151 citations
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1979 • 146 citations
Reduction of Ischemic Injury by Nitroglycerin during Acute Myocardial Infarction
1975 • 140 citations
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1983 • 140 citations
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1983 • 137 citations
Hemodynamics and antianginal effects of high dose oral isosorbide dinitrate after chronic use.
1977 • 135 citations
Vasodilator therapy for chronic left ventricular failure.
1976 • 134 citations
Intravenous nitroglycerin for the treatment of angina at rest unresponsive to standard nitrate therapy
1983 • 134 citations
Coronary Artery Occlusion in the Conscious Dog
1973 • 130 citations
Management of vasospastic angina at rest with continuous infusion of isosorbide dinitrate
1979 • 130 citations
Hemodynamic assessment of oral peripheral vasodilator therapy in chronic congestive heart failure: Prolonged effectiveness of isosorbide dinitrate
1977 • 129 citations
Transdermal isosorbide dinitrate in angina pectoris: Effect of acute and sustained therapy
1984 • 129 citations
Antianginal effects of intravenous nitroglycerin over 24 hours.
1988 • 129 citations
Long-term prognosis of patients with variant angina.
1987 • 127 citations
Nitrate Therapy in Stable Angina Pectoris
1987 • 125 citations
Isosorbide Dinitrate
1975 • 122 citations
Sustained hemodynamic and antianginal effect of high dose oral isosorbide dinitrate.
1977 • 121 citations
Tolerance to the vascular effects of glyceryl trinitrate.
1970 • 119 citations
Angina Pectoris: Pathophysiology, Evaluation, and Treatment
1971 • 119 citations
Some Effects of Nitroglycerin upon the Splanchnic, Pulmonary, and Systemic Circulations
1966 • 117 citations
The effect of nitroglycerin on coronary blood flow and the hemodynamic response to exercise in coronary artery disease
1971 • 114 citations
A study of cross-tolerance to circulatory effects of organic nitrates
1967 • 113 citations
Intravenous nitroglycerin in the treatment of spontaneous angina pectoris: a prospective, randomized trial.
1983 • 113 citations
Oral isosorbide dinitrate in the treatment of angina pectoris. Dose-response relationship and duration of action during acute therapy.
1980 • 111 citations
Nitroglycerin Pharmacokinetics After Intravenous Infusion in Normal Subjects
1981 • 109 citations
Nitrate tolerance and dependence
1980 • 109 citations
Pharmacokinetic-hemodynamic studies of nitroglycerin ointment in congestive heart failure
1980 • 108 citations
Potentiation of nitroglycerin-induced coronary dilatation by N-acetylcysteine.
1986 • 108 citations
Randomized double-blind comparison of nifedipine and isosorbide dinitrate in patients with coronary arterial spasm
1982 • 106 citations
Transdermal Nitroglycerin Patches in Angina Pectoris
1986 • 104 citations
Failure of transdermal nitroglycerin to improve chronic stable angina: A randomized, placebo-controlled, double-blind, double crossover trial
1984 • 103 citations
Reduction in Severity and Extent of Myocardial Infarction When Nitroglycerin and Methoxamine are Administered during Coronary Occlusion
1974 • 103 citations
Circulatory changes associated with spontaneous angina pectoris
1966 • 98 citations
Active transient myocardial ischemia during daily life in asymptomatic patients with positive exercise tests and coronary artery disease
1986 • 98 citations
Nitrate tolerance: the lack of effect of N-acetylcysteine.
1987 • 97 citations
Orally administered isosorbide dinitrate in patients with and without left ventricular failure due to acute myocardial infarction
1977 • 91 citations
ACQUIRED TOLERANCE TO AND CROSS TOLERANCE BETWEEN THE NITROUS AND NITRIC ACID ESTERS AND SODIUM NITRITE IN MAN
1931 • 90 citations
Management of Stable Angina
1973 • 89 citations
Effect of sublingual nitroglycerin on regional flow in patients with and without coronary disease.
1978 • 88 citations
THE TREATMENT OF ANGINA PECTORIS WITH A NITROGLYCERIN OINTMENT
1955 • 86 citations
The Clinical Use of Transdermal Delivery Devices with Nitroglycerin
1983 • 84 citations
Therapeutic efficacy of a new transdermal system containing nitroglycerin in patients with angina pectoris
1982 • 82 citations
Failure of transdermal nitroglycerin to improve exercise capacity in patients with angina pectoris
1985 • 82 citations
The long-acting hemodynamic effects of isosorbide dinitrate
1972 • 82 citations
Therapy of angina pectoris with propranolol and long-acting nitrates.
1969 • 82 citations
Tolerance development during isosorbide dinitrate treatment: can it be circumvented?
1983 • 79 citations
The brief saga of transdermal nitroglycerin discs: Paradise lost?
1984 • 77 citations
Beneficial electrophysiologic effects of nitroglycerin during acute myocardial infarction
1974 • 77 citations
Sustained antianginal efficacy of transdermal nitroglycerin patches using an overnight 10-hour nitrate-free interval
1988 • 75 citations
THE EFFECTS OF NITROGLYCERIN ON THOSE ENGAGED IN ITS MANUFACTURE
1914 • 74 citations
Nitroglycerin lingual spray: Clinical efficacy and dose-response relation
1986 • 73 citations
Comparison of buccal nitroglycerin and oral isosorbide dinitrate for nitrate tolerance in stable angina pectoris
1985 • 72 citations
Clinical Pharmacokinetics of Glyceryl Trinitrate Following the Use of Systemic and Topical Preparations
1987 • 70 citations
Plasma nitroglycerin levels after sublingual, oral and topical administration.
1977 • 69 citations
Mode of action of nitrglycerin in angina pectoris. Correlation between haemodynamic effects during exercise and prevention of pain.
1968 • 69 citations
Transdermal nitroglycerin in angina pectoris: Efficacy of intermittent application
1987 • 67 citations
Effects of Nitroglycerin on "Maximal" Oxygen Intake and Exercise Electrocardiogram in Coronary Heart Disease
1971 • 67 citations
Sustained effect of orally administered isosorbide dinitrate on exercise performance of patients with angina pectoris
1979 • 67 citations
TOLERANCE TO NITROGLYCERIN.
1905 • 66 citations
[Condition following myocardial infarct: which studies at what time and with what patients?].
1983 • 64 citations
Persistent reduction in left ventricular asynergy in patients with acute myocardial infarction by intravenous infusion of nitroglycerin.
1983 • 64 citations
Relief of Refractory Angina with Continuous Intravenous Infusion of Nitroglycerin
1980 • 64 citations
Kinetics of isosorbide dinitrate and relationships to pharmacological effects.
1981 • 62 citations
Effect of nitroglycerin ointment on the clinical and hemodynamic response to exercise
1976 • 61 citations
The Cause, Relief and Prevention of Headaches Arising from Contact with Dynamite
1946 • 61 citations
Effect of swallowed isosorbide dinitrate on blood pressure, heart rate and exercise capacity in patients with coronary artery disease
1977 • 60 citations
Haemodynamic effects of angina pectoris, and of nitroglycerin in normal and anginal subjects.
1966 • 60 citations
Angina pectoris. I.
1971 • 60 citations
Antianginal Efficacy of Oral Therapy with Isosorbide Dinitrate Capsules
1978 • 59 citations
Effect of a new transdermal therapeutic system containing nitroglycerin on exercise capacity in patients with angina pectoris
1985 • 58 citations
Isosorbide 5‐mononitrate pharmacokinetics in humans
1981 • 57 citations
A Reappraisal of Nitrate Therapy
1988 • 57 citations
Tolerance towards glyceryl trinitrate (trinitrin) in dogs.
1968 • 55 citations
Intravenous Nitroglycerin for Rest Angina
1982 • 55 citations
A multicenter trial of transdermal nitroglycerin in exercise-induced angina: Individual antianginal response after repeated administration
1986 • 55 citations
Incomplete and delayed bioavailability of sublingual nitroglycerin
1985 • 53 citations
Induction and circumvention of nitrate tolerance applying different dosage intervals
1987 • 52 citations
Nitroglycerin and long-acting nitrates in clinical practice
1983 • 52 citations
HARMFUL EFFECTS OF NITROGLYCERIN. With Special Reference to Coronary Thrombosis
1932 • 52 citations
Nitroglycerin ointment in acute myocardial infarction
1976 • 51 citations
Pharmacokinetic determinants of nitrate action
1984 • 51 citations
Duration of effects and tolerance of slow-release isosorbide-5-mononitrate for angina pectoris
1987 • 50 citations
Intravenous Nitroglycerine in Refractory Unstable Angina Pectoris
1982 • 50 citations
Efficacy of transdermal glyceryl trinitrate in the treatment of chronic stable angina pectoris.
1985 • 49 citations
Pathogenesis of angina pectoris and role of nitrates in relief of myocardial ischemia
1983 • 48 citations
Syndrome of Severe Bradycardia and Hypotension following Sublingual Nitroglycerin Administration
1981 • 48 citations
Isosorbide dinitrate kinetics and dynamics after intravenous, sublingual, and percutaneous dosing in angina
1983 • 45 citations
Nocturnal angina: precipitating factors in patients with coronary artery disease and those with variant angina.
1986 • 45 citations
Isosorbide dinitrate and glyceryl trinitrate: Demonstration of cross tolerance in the capacitance vessels
1985 • 45 citations
Plasma concentrations and haemodynamic effects of nitroglycerin during and after intravenous infusion in healthy volunteers
1982 • 45 citations
Nitrates in the Prophylactic Treatment of Angina Pectoris
1973 • 42 citations
Mechanisms and therapy of silent myocardial ischemia and the effect of transdermal nitroglycerin
1985 • 42 citations
Nitroglycerin: a homeopathic remedy.
1986 • 42 citations
Acute and sustained effects of isosorbide 5-mononitrate in stable angina pectoris
1986 • 39 citations
Comparative hemodynamic effects of placebo and oral isosorbide dinitrate in patients with significant coronary artery disease
1975 • 39 citations
Prolonged salutary effects of isosorbide dinitrate and nitroglycerin ointment on regional left ventricular function
1977 • 39 citations
Evaluation of Nitroglycerin in Angina in Patients on Isosorbide Dinitrate
1970 • 38 citations
Isosorbide 5-mononitrate kinetics
1984 • 38 citations
Relationship of Pharmacokinetic and Pharmacodynamic Properties of the Organic Nitrates
1988 • 37 citations
Dose dependence of tolerance during treatment with mononitrates.
1983 • 37 citations
Plasma concentrations of isosorbide dinitrate and its metabolites after chronic high oral dosage in man.
1978 • 37 citations
Clinical Pharmacokinetics of Organic Nitrates
1983 • 37 citations
Effect of nitrates on left ventricular size and function during exercise: Comparison of sublingual nitroglycerin and nitroglycerin paste
1980 • 37 citations
The effects of nitroglycerin on cyclic nucleotides in the coronary artery
1980 • 36 citations
Pharmacokinetics and metabolism of isosorbide-dinitrate after intravenous and oral administration
1985 • 36 citations
Occupational habituation to aliphatic nitrates and the withdrawal hazards of coronary disease and hypertension.
1977 • 34 citations
Use of Nitrate and Nitrite Vasodilators by Glaucomatous Patients
1964 • 34 citations
The Effect of Nitroglycerin Ointment on the Exercise Capacity in Patients with Angina Pectoris
1976 • 34 citations
Dynamic vascular factors in the genesis of myocardial ischemia
1983 • 33 citations
Usefulness of twice-daily isosorbide-5-mononitrate in preventing development of tolerance in angina pectoris
1987 • 33 citations
Tolerance to glyceryl trinitrate patches: prevention by intermittent dosing.
1987 • 33 citations
Prolonged benefit of nitroglycerin ointment on exercise tolerance in patients with angina pectoris
1978 • 32 citations
Cardiocirculatory and Antianginal Actions of Nitroglycerin Ointment
1978 • 31 citations
Exercise capacity with transdermal nitroglycerin in patients with stable angina pectoris
1984 • 30 citations
Analysis, disposition and pharmacokinetics of nitroglycerin
1985 • 30 citations
A Double-Blind Cross-Over Study on the Effectiveness and Possible Development of Tolerance during Long-Term Therapy with Isosorbide-5-Mononitrate or Isosorbide Dinitrate Slow-Release in Coronary Artery Disease
1985 • 29 citations
The effects of moderate sustained exercise on the pharmacokinetics of nitroglycerine.
1987 • 27 citations
Studies on compensatory reflexes and tolerance to glyceryl trinitrate (GTN)
1971 • 27 citations
Post-Marketing Surveillance of the Transiderm-Nitro Patch in General Practice
1984 • 26 citations
Prophylactic Therapy of Angina Pectoris With Organic Nitrates: Relationship of Drug Efficacy and Clinical Experimental Design
1973 • 25 citations
Dose-response relation of antianginal activity of isosorbide dinitrate
1984 • 24 citations
"Monday Head": An Interesting Occupational Disorder
1961 • 24 citations
Effect of glyceryl trinitrate on echocardiographic left ventricular dimensions during exercise in the upright position.
1979 • 24 citations
Dose-dependent effects of isosorbide-5-mononitrate on the venous arterial and coronary arterial system of conscious dogs
1986 • 22 citations
Influence of glyceryl trinitrate during supine and upright exercise in patients with angina pectoris.
1978 • 21 citations
Effects of Acute and Chronic Administration of Isosorbide Dinitrate, Sustained-Release Form, in Patients with Angina Pectoris
1981 • 19 citations
The Additive Antianginal Action of Oral Isosorbide Dinitrate in Patients Receiving Propranolol
1983 • 19 citations
Complete Heart Block after Sublingual Nitroglycerin
1983 • 19 citations
Methemoglobin Levels Produced by Organic Nitrates in Patients with Coronary Artery Disease
1984 • 19 citations
Coronary and myocardial metabolic effects of combined glyceryl trinitrate and propranolol administration. Observations in patients with and without coronary disease.
1978 • 19 citations
Antianginöse Wirkung von transdermal appliziertem Nitroglycerin in Abhängigkeit von der Pflastergröße
2008 • 18 citations
Organic nitrates: tolerance at the level of the vascular smooth muscle.
1971 • 18 citations
Oral sustained-release nitroglycerin in chronic stable angina: A multicenter, double-blind, randomized crossover trial
1984 • 18 citations
The Prolonged Effect of Pentaerythritol Tetranitrate on Exercise Capacity in Stable Effort Angina Pectoris
1981 • 17 citations
Plasma concentrations of isosorbide dinitrate after oral administration of a sustained-release formulation to human subjects.
1977 • 16 citations
Role of the liver in the disposition of intravenous nitroglycerin in the rat
1984 • 16 citations
Determination of Nitroglycerin and Its Dinitrate Metabolites in Human Plasma by High-Performance Liquid Chromatography with Thermal Energy Analyzer Detection
1984 • 16 citations
Mechanism of nitroglycerin-induced coronary dilatation: Lack of relation to intracoronary thromboxane concentrations
1984 • 16 citations
Use of Nitrates as Antianginal Agents
1975 • 15 citations
THE RATE OF ELIMINATION OF GLYCERYL TRINITRATE FROM THE BLOOD STREAM AFTER INTRAVENOUS ADMINISTRATION IN DOGS
1929 • 15 citations
Isosorbide 5-Mononitrate Pharmacokinetics
1987 • 14 citations
Sustained anti‐anginal action of glyceryl trinitrate cream.
1983 • 14 citations
Excessive reduction in peripheral resistance during exercise and risk of orthostatic symptoms with sustained-release nitroglycerin and diltiazem treatment of angina
1985 • 14 citations
Intravenous Nitroglycerin in Unstable Angina
1981 • 14 citations
Double-blind crossover comparison of the antianginal effects of nifedipine and isosorbide dinitrate in patients with exertional angina receiving propranolol
1985 • 14 citations
Fate of orally given isosorbide dinitrate in man: factors of variability.
1983 • 13 citations
Cutaneous Administration of Nitroglycerin in Patients with Angina Pectoris
1981 • 13 citations
Nitroglycerin-Induced Asystole
1985 • 13 citations
Complete atrioventricular block after sublingual isosorbide dinitrate
1986 • 13 citations
The Effect of Pindolol and Isosorbide Dinitrate and Their Combination on Exercise Tolerance and ECG Changes in Angina Pectoris
1981 • 12 citations
Isosorbide-5-mononitrate in angina pectoris: Plasma concentrations and duration of effects after acute therapy
1987 • 11 citations
The effectiveness of transcutaneous nitrate preparations for angina pectoris
1987 • 11 citations
Assessment of dermal glyceryl trinitrate and isosorbide dinitrate for patients with angina pectoris.
1985 • 11 citations
Nitrate Tolerance A Relevant Clinical Problem?
1987 • 10 citations
Beneficial Effects of Isosorbide-5-Mononitrate on Exercise Performance in Patients with Chronic Stable Angina Pectoris
1985 • 9 citations
Paradoxical pulmonary vasoconstriction induced by nitroglycerin in idiopathic pulmonary hypertension
1985 • 9 citations
Efficacy of long-acting nitrates
1976 • 9 citations
Double-Blind, Randomized Crossover Study on the Coronary Therapeutic Efficacy and Tolerance of IS-5-MN (ISMO 20) in Comparison with IS-5-MN + Metipranolol (ISMO-DISORAT 20/5) and Placebo
1985 • 8 citations
Comparison of nitroglycerin-tts and long-acting nitroglycerin tablets in the treatment of angina pectoris: A double-blind controlled study
1987 • 8 citations
Reduction of infarct size by intravenous nitroglycerin infusion in conscious dogs
1978 • 7 citations
Nitrate therapy: continuous or pulse dosing.
1987 • 6 citations
Comparison of Changes on Exercise-Induced Ischemia After a Single Oral Dose of IS-5-MN and ISDN
1985 • 6 citations
Interaction of indomethacin and nitroglycerin on hemodynamics and exercise tolerance in patients with angina pectoris.
1983 • 6 citations
Dose response and duration of action of oral isosorbide dinitrate during sustained therapy in angina pectoris
1980 • 6 citations
Pharmacodynamics of Organic Nitrates — In Vitro and In Vivo Studies
1987 • 4 citations
Transgingival nitrate syncope.
1986 • 4 citations
Deleted Work
1955 • 0 citations