Effects of 8:00 A.M. and 2:00 P.M. Doses of isosorbide-5-mononitrate during twice-daily therapy in stable angina pectoris

Oral Isosorbide dinitrate in angina pectoris: Comparison of duration of action and dose-response relation during acute and sustained therapy

1982 • 303 citations

Trainsdermal nitroglycerin in angina pectoris

1984 • 257 citations

Effect of Intervals between Doses on the Development of Tolerance to Isosorbide Dinitrate

1987 • 218 citations

Tolerance to the circulatory effects of oral isosorbide dinitrate. Rate of development and cross-tolerance to glyceryl trinitrate.

1980 • 196 citations

Intermittent transdermal nitroglycerin therapy in the treatment of chronic stable angina

1989 • 190 citations

Tolerance to Organic Nitrates: Evidence, Mechanisms, Clinical Relevance, and Strategies for Prevention

1991 • 151 citations

Antianginal effects of intravenous nitroglycerin over 24 hours.

1988 • 129 citations

Transdermal Nitroglycerin Patches in Angina Pectoris

1986 • 104 citations

Acute and chronic antianginal efficacy of continuous twenty-four-hour application of transdermal nitroglycerin

1991 • 89 citations

Tolerance development during isosorbide dinitrate treatment: can it be circumvented?

1983 • 79 citations

Sustained antianginal efficacy of transdermal nitroglycerin patches using an overnight 10-hour nitrate-free interval

1988 • 75 citations

Clinical Pharmacokinetics of Glyceryl Trinitrate Following the Use of Systemic and Topical Preparations

1987 • 70 citations

[Condition following myocardial infarct: which studies at what time and with what patients?].

1983 • 64 citations

Isosorbide 5‐mononitrate pharmacokinetics in humans

1981 • 57 citations

A Reappraisal of Nitrate Therapy

1988 • 57 citations

Induction and circumvention of nitrate tolerance applying different dosage intervals

1987 • 52 citations

Limited usefulness of intermittent nitroglycerin patches in stable angina

1989 • 46 citations

Relationship of Pharmacokinetic and Pharmacodynamic Properties of the Organic Nitrates

1988 • 37 citations

Clinical Pharmacokinetics of Organic Nitrates

1983 • 37 citations

Dose dependence of tolerance during treatment with mononitrates.

1983 • 37 citations

The daylong pattern of the antianginal effect of long-term three times daily administered isosorbide dinitrate

1990 • 37 citations

Pharmacokinetics and metabolism of isosorbide-dinitrate after intravenous and oral administration

1985 • 36 citations

Nitrate therapy for myocardial ischemic syndromes: Current perspectives including tolerance

1988 • 34 citations

Tolerance to glyceryl trinitrate patches: prevention by intermittent dosing.

1987 • 33 citations

Usefulness of twice-daily isosorbide-5-mononitrate in preventing development of tolerance in angina pectoris

1987 • 33 citations

Interval therapy to avoid nitrate tolerance: Paradise regained?

1989 • 31 citations

Analysis, disposition and pharmacokinetics of nitroglycerin

1985 • 30 citations

Nitrate tolerance: a clinically significant problem?

1984 • 11 citations

Isosorbide-5-mononitrate in angina pectoris: Plasma concentrations and duration of effects after acute therapy

1987 • 11 citations

Nitrate Tolerance A Relevant Clinical Problem?

1987 • 10 citations

Overview of the Pharmacokinetics of Isosorbide-5-Mononitrate

1987 • 3 citations