Oxidative Stress-mediated, Post-translational Loss of MafA Protein as a Contributing Mechanism to Loss of Insulin Gene Expression in Glucotoxic Beta Cells

Isolation and Characterization of Full-Length cDNA Clones for Human α-, β-, and γ-Actin mRNAs: Skeletal but Not Cytoplasmic Actins Have an Amino-Terminal Cysteine that Is Subsequently Removed

1983 • 1,220 citations

Glucose Toxicity in β-Cells: Type 2 Diabetes, Good Radicals Gone Bad, and the Glutathione Connection

2003 • 878 citations

Beneficial effects of antioxidants in diabetes: possible protection of pancreatic beta-cells against glucose toxicity.

1999 • 716 citations

Prevention of glucose toxicity in HIT-T15 cells and Zucker diabetic fatty rats by antioxidants

1999 • 457 citations

Regulation of insulin gene transcription

2002 • 354 citations

Prolonged exposure of human pancreatic islets to high glucose concentrations in vitro impairs the beta-cell function.

1992 • 309 citations

Identification of β-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA

2002 • 304 citations

MafA Is a Glucose-regulated and Pancreatic β-Cell-specific Transcriptional Activator for the Insulin Gene

2002 • 294 citations

Members of the Large Maf Transcription Family Regulate Insulin Gene Transcription in Islet β Cells

2003 • 291 citations

The world according to Maf

1997 • 285 citations

The Maf transcription factors: regulators of differentiation

1997 • 272 citations

The MafA transcription factor appears to be responsible for tissue-specific expression of insulin

2004 • 269 citations

v-maf, a viral oncogene that encodes a "leucine zipper" motif.

1989 • 266 citations

Preservation of insulin mRNA levels and insulin secretion in HIT cells by avoidance of chronic exposure to high glucose concentrations.

1992 • 233 citations

Chronic exposure of HIT cells to high glucose concentrations paradoxically decreases insulin gene transcription and alters binding of insulin gene regulatory protein.

1993 • 212 citations

Chronic exposure of betaTC-6 cells to supraphysiologic concentrations of glucose decreases binding of the RIPE3b1 insulin gene transcription activator.

1996 • 155 citations

Pancreatic beta-cell-type-specific transcription of the insulin gene is mediated by basic helix-loop-helix DNA-binding proteins.

1991 • 150 citations

Cell-specific and ubiquitous factors are responsible for the enhancer activity of the rat insulin II gene.

1991 • 130 citations

Differential expression of the insulin gene transcriptional repressor CCAAT/enhancer-binding protein beta and transactivator islet duodenum homeobox-1 in rat pancreatic beta cells during the development of diabetes mellitus.

1998 • 121 citations

Differentially expressed Maf family transcription factors, c-Maf and MafA, activate glucagon and insulin gene expression in pancreatic islet alpha- and beta-cells

2004 • 83 citations

Insulin Secretion and cAMP Metabolism in HIT Cells: Reciprocal and Serial Passage-Dependent Relationships

1989 • 78 citations

mafA, a novel member of the maf proto-oncogene family, displays developmental regulation and mitogenic capacity in avian neuroretina cells

1998 • 76 citations

The Islet ॆ Cell-enriched RIPE3b1/Maf Transcription Factor Regulates pdx-1 Expression

2003 • 59 citations

Mouse MafA, homologue of zebrafish somite Maf 1, contributes to the specific transcriptional activity through the insulin promoter

2003 • 58 citations

Oxidative stress induces the levels of a MAFG homolog in hamster HA-1 cells

1996 • 56 citations

Cooperativity of sequence elements mediates tissue specificity of the rat insulin II gene.

1990 • 56 citations

Reconstitution of glucotoxic HIT-T15 cells with somatostatin transcription factor-1 partially restores insulin promoter activity.

1998 • 41 citations

Glucose and other insulin secretagogues induce, rather than inhibit, expression of Id-1 and Id-3 in pancreatic islet beta cells

2001 • 35 citations

Sequence of a cDNA Encoding Syrian Hamster Preproinsulin

1984 • 28 citations

A RIPE3b1‐like factor binds to a novel site in the human insulin promoter in a redox‐dependent manner

1997 • 17 citations

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