TIMP Independence of Matrix Metalloproteinase (MMP)-2 Activation by Membrane Type 2 (MT2)-MMP Is Determined by Contributions of Both the MT2-MMP Catalytic and Hemopexin C Domains

New functions for the matrix metalloproteinases in cancer progression

2002 • 5,937 citations

Matrix Metalloproteinases

1999 • 3,774 citations

A matrix metalloproteinase expressed on the surface of invasive tumour cells

1994 • 2,561 citations

Mechanism Of Cell Surface Activation Of 72-kDa Type IV Collagenase

1995 • 1,576 citations

Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I

2000 • 792 citations

Cellular Mechanisms for Human Procollagenase-3 (MMP-13) Activation

1996 • 741 citations

Regulation of Cell Invasion and Morphogenesis in a Three-Dimensional Type I Collagen Matrix by Membrane-Type Matrix Metalloproteinases 1, 2, and 3

2000 • 588 citations

The TIMP2 Membrane Type 1 Metalloproteinase “Receptor” Regulates the Concentration and Efficient Activation of Progelatinase A

1998 • 578 citations

The Soluble Catalytic Domain of Membrane Type 1 Matrix Metalloproteinase Cleaves the Propeptide of Progelatinase A and Initiates Autoproteolytic Activation

1996 • 564 citations

MT1‐MMP: A potent modifier of pericellular microenvironment

2005 • 484 citations

Identification of the Second Membrane-type Matrix Metalloproteinase (MT-MMP-2) Gene from a Human Placenta cDNA Library

1995 • 474 citations

Membrane‐Type Matrix Metalloproteinases 1 and 2 Exhibit Broad‐Spectrum Proteolytic Capacities Comparable to Many Matrix Metalloproteinases

1997 • 434 citations

TIMP-2 Is Required for Efficient Activation of proMMP-2 in Vivo

2000 • 383 citations

Homophilic complex formation of MT1-MMP facilitates proMMP-2 activation on the cell surface and promotes tumor cell invasion

2001 • 382 citations

Crystal structure of the complex formed by the membrane type 1-matrix metalloproteinase with the tissue inhibitor of metalloproteinases-2, the soluble progelatinase A receptor

1998 • 360 citations

Molecular cloning of a novel membrane-type matrix metalloproteinase from a human breast carcinoma.

1996 • 330 citations

Activation of progelatinase A (MMP‐2) by neutrophil elastase, cathepsin G, and proteinase‐3: A role for inflammatory cells in tumor invasion and angiogenesis

2001 • 324 citations

cDNA Sequence and mRNA Tissue Distribution of a Novel Human Matrix Metalloproteinase with a Potential Transmembrane Segment

1995 • 319 citations

Structural aspects of the metzincin clan of metalloendopeptidases

2003 • 312 citations

Tissue Inhibitor of Metalloproteinase-2 (TIMP-2) Binds to the Catalytic Domain of the Cell Surface Receptor, Membrane Type 1-Matrix Metalloproteinase 1 (MT1-MMP)

1998 • 285 citations

Expression and tissue localization of membrane-types 1, 2, and 3 matrix metalloproteinases in human invasive breast carcinomas.

1997 • 281 citations

Membrane protease proteomics: Isotope-coded affinity tag MS identification of undescribed MT1–matrix metalloproteinase substrates

2004 • 271 citations

Identification and Characterization of the Fifth Membrane-type Matrix Metalloproteinase MT5-MMP

1999 • 261 citations

Regulation of membrane-type matrix metalloproteinase 1 activity by dynamin-mediated endocytosis

2001 • 253 citations

cDNA Sequence and mRNA Tissue Distribution of a Novel Human Matrix Metalloproteinase with a Potential Transmembrane Segment

1995 • 244 citations

Intermolecular Autolytic Cleavage Can Contribute to the Activation of Progelatinase A by Cell Membranes

1995 • 242 citations

Endothelial tubulogenesis within fibrin gels specifically requires the activity of membrane-type-matrix metalloproteinases (MT-MMPs)

2002 • 238 citations

Extracellular Matrix Binding Properties of Recombinant Fibronectin Type II-like Modules of Human 72-kDa Gelatinase/Type IV Collagenase

1995 • 221 citations

Expression and Tissue Localization of Membrane-Type 1, 2, and 3 Matrix Metalloproteinases in Human Astrocytic Tumors

1999 • 220 citations

Claudin Promotes Activation of Pro-matrix Metalloproteinase-2 Mediated by Membrane-type Matrix Metalloproteinases

2001 • 218 citations

Membrane Type 4 Matrix Metalloproteinase (MMP17) Has Tumor Necrosis Factor-α Convertase Activity but Does Not Activate Pro-MMP2

2000 • 218 citations

Matrix Metalloproteinases (MMPs) Regulate Fibrin-invasive Activity via MT1-MMP–dependent and –independent Processes

2002 • 215 citations

Leukolysin/MMP25/MT6-MMP: a novel matrix metalloproteinase specifically expressed in the leukocyte lineage

1999 • 203 citations

Human MT6-matrix metalloproteinase: identification, progelatinase A activation, and expression in brain tumors.

2000 • 195 citations

Processing, shedding, and endocytosis of membrane type 1‐matrix metalloproteinase (MT1‐MMP)

2004 • 189 citations

Expression of Matrix Metalloproteinases and Their Tissue Inhibitors in Human Brain Tumors

1998 • 185 citations

Cell surface binding and activation of gelatinase A induced by expression of membrane‐type‐1‐matrix metalloproteinase (MT1‐MMP)

1996 • 182 citations

Cellular Activation of MMP-2 (Gelatinase A) by MT2-MMP Occurs via a TIMP-2-independent Pathway

2001 • 178 citations

MT1‐MMP: A tethered collagenase

2004 • 175 citations

Roles of membrane‐type matrix metalloproteinase‐1 in tumor invasion and metastasis

2005 • 174 citations

Extracellular Matrix-Driven Matrix Metalloproteinase Production in Endothelial Cells

1999 • 169 citations

Functional Interplay between Type I Collagen and Cell Surface Matrix Metalloproteinase Activity

2001 • 168 citations

Membrane‐Type‐2 Matrix Metalloproteinase Can Initiate the Processing of Progelatinase A and is Regulated by the Tissue Inhibitors of Metalloproteinases

1997 • 164 citations

Membrane Type 4 Matrix Metalloproteinase (MT4-MMP, MMP-17) Is a Glycosylphosphatidylinositol-anchored Proteinase

1999 • 163 citations

Characterization of the Distinct Collagen Binding, Helicase and Cleavage Mechanisms of Matrix Metalloproteinase 2 and 14 (Gelatinase A and MT1-MMP)

2004 • 157 citations

Plasmin activates pro‐matrix metalloproteinase‐2 with a membrane‐type 1 matrix metalloproteinase‐dependent mechanism

2002 • 154 citations

Membrane type-matrix metalloproteinases and tumor progression

2004 • 142 citations

Tissue inhibitor of metalloproteinases-4 inhibits but does not support the activation of gelatinase A via efficient inhibition of membrane type 1-matrix metalloproteinase.

2001 • 140 citations

Differential Inhibition of Membrane Type 3 (MT3)-Matrix Metalloproteinase (MMP) and MT1-MMP by Tissue Inhibitor of Metalloproteinase (TIMP)-2 and TIMP-3 Regulates Pro-MMP-2 Activation

2004 • 139 citations

Membrane‐type 6 matrix metalloproteinase (MT6‐MMP, MMP‐25) is the second glycosyl‐phosphatidyl inositol (GPI)‐anchored MMP

2000 • 135 citations

Collagen Binding Properties of the Membrane Type-1 Matrix Metalloproteinase (MT1-MMP) Hemopexin C Domain

2002 • 134 citations

Activation of pro-(matrix metalloproteinase-2) (pro-MMP-2) by thrombin is membrane-type-MMP-dependent in human umbilical vein endothelial cells and generates a distinct 63 kDa active species

2001 • 122 citations

Gelatinase A and membrane-type matrix metalloproteinases 1 and 2 are responsible for follicle rupture during ovulation in the medaka

2005 • 111 citations

Processing of a precursor of 72-kilodalton type IV collagenase/gelatinase A by a recombinant membrane-type 1 matrix metalloproteinase.

1996 • 110 citations

The Hemopexin-like Domain (C Domain) of Human Gelatinase A (Matrix Metalloproteinase-2) Requires Ca2+ for Fibronectin and Heparin Binding

1997 • 107 citations

Characterization of a truncated recombinant form of human membrane type 3 matrix metalloproteinase

1999 • 100 citations

Domain Interactions in the Gelatinase A·TIMP-2·MT1-MMP Activation Complex

2000 • 99 citations

The chemokine stromal cell derived factor-1 (CXCL12) promotes glioma invasiveness through MT2-matrix metalloproteinase

2005 • 91 citations

Catalytic Activities and Substrate Specificity of the Human Membrane Type 4 Matrix Metalloproteinase Catalytic Domain

1999 • 90 citations

The Involvement of the Fibronectin Type II-like Modules of Human Gelatinase A in Cell Surface Localization and Activation

1998 • 89 citations

Glycosylation Broadens the Substrate Profile of Membrane Type 1 Matrix Metalloproteinase

2004 • 87 citations

Identification of the Tissue Inhibitor of Metalloproteinases-2 (TIMP-2) Binding Site on the Hemopexin Carboxyl Domain of Human Gelatinase A by Site-directed Mutagenesis

1999 • 81 citations

Identification of MMP-15 as an Anti-apoptotic Factor in Cancer Cells

2005 • 77 citations

Characterization of the Role of the “MT-loop”

2001 • 75 citations

Activation of pro-(matrix metalloproteinase-2) (pro-MMP-2) by thrombin is membrane-type-MMP-dependent in human umbilical vein endothelial cells and generates a distinct 63 kDa active species

2001 • 74 citations

Dissecting the Role of Matrix Metalloproteinases (MMP) and Integrin αvβ3 in AngiogenesisIn vitro: Absence of Hemopexin C Domain Bioactivity, but Membrane-Type 1-MMP and αvβ3 Are Critical

2005 • 69 citations

Expression of Membrane-Type 1, 2, and 3 Matrix Metalloproteinases Messenger RNA in Ovarian Carcinoma Cells in Serous Effusions

2001 • 57 citations

Matrix Metalloproteinase Protocols

2010 • 55 citations

Isolation of a mouse MT2‐MMP gene from a lung cDNA library and identification of its product

1997 • 55 citations

Activation of Progelatinase A and Progelatinase A/TIMP-2 Complex by Membrane Type 2-Matrix Metalloproteinase

1997 • 52 citations

Type I Collagen Abrogates the Clathrin-mediated Internalization of Membrane Type 1 Matrix Metalloproteinase (MT1-MMP) via the MT1-MMP Hemopexin Domain

2005 • 50 citations

Expression pattern of four membrane‐type matrix metalloproteinases in the normal and diseased mouse mammary gland

2005 • 49 citations

Matrix Metalloproteinase Protocols

2000 • 47 citations

Expression and tissue localization of membrane-types 1, 2, and 3 matrix metalloproteinases in human urothelial carcinomas.

1998 • 45 citations

Malignant conversion of non-tumorigenic murine skin keratinocytes overexpressing PACE4

2002 • 44 citations

Pivotal Molecular Determinants of Peptidic and Collagen Triple Helicase Activities Reside in the S3′ Subsite of Matrix Metalloproteinase 8 (MMP-8)

2004 • 41 citations

EXPRESSION AND TISSUE LOCALIZATION OF MEMBRANE-TYPES 1, 2, AND 3 MATRIX METALLOPROTEINASES IN HUMAN UROTHELIAL CARCINOMAS

1998 • 40 citations

The Hemopexin Domain of Membrane-type Matrix Metalloproteinase-1 (MT1-MMP) Is Not Required for Its Activation of proMMP2 on Cell Surface but Is Essential for MT1-MMP-mediated Invasion in Three-dimensional Type I Collagen

2004 • 39 citations

Distinct Roles of Catalytic and Pexin-like Domains in Membrane-type Matrix Metalloproteinase (MMP)-mediated Pro-MMP-2 Activation and Collagenolysis

2003 • 38 citations

Utilization of a Novel Recombinant Myoglobin Fusion Protein Expression System to Characterize the Tissue Inhibitor of Metalloproteinase (TIMP)-4 and TIMP-2 C-terminal Domain and Tails by Mutagenesis

2002 • 32 citations

Human Membrane Type-2 Matrix Metalloproteinase Is Defective in Cell-Associated Activation of Progelatinase A

2000 • 29 citations

Monitoring MMP and TIMP mRNA Expression by RT-PCR

2003 • 20 citations

Mutational and Structural Analyses of the Hinge Region of Membrane Type 1-Matrix Metalloproteinase and Enzyme Processing

2005 • 13 citations