What will be the role of I-123 MIBG in improving the outcome of medically treated heart failure patients?

Should We STOP Angiotensin Converting Enzyme Inhibitors/Angiotensin Receptor Blockers in Advanced Kidney Disease?

2016 • 11,500 citations

Effect of Enalapril on Survival in Patients with Reduced Left Ventricular Ejection Fractions and Congestive Heart Failure

1991 • 8,296 citations

Effect of Captopril on Mortality and Morbidity in Patients with Left Ventricular Dysfunction after Myocardial Infarction

1992 • 5,885 citations

The Cardiac Insufficiency Bisoprolol Study II (CIBIS-II): a randomised trial

1999 • 5,053 citations

Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in-Congestive Heart Failure (MERIT-HF)

1999 • 4,963 citations

Effects of Enalapril on Mortality in Severe Congestive Heart Failure

1987 • 4,763 citations

The Effect of Carvedilol on Morbidity and Mortality in Patients with Chronic Heart Failure

1996 • 4,580 citations

Heart Disease and Stroke Statistics—2009 Update

2009 • 3,914 citations

Effects of enalapril on mortality in severe congestive heart failure: Results of the Cooperative North Scandinavian Enalapril Survival Study (CONSENSUS)

1988 • 3,818 citations

Effect of Enalapril on Mortality and the Development of Heart Failure in Asymptomatic Patients with Reduced Left Ventricular Ejection Fractions

1992 • 3,708 citations

Plasma Norepinephrine as a Guide to Prognosis in Patients with Chronic Congestive Heart Failure

1984 • 3,130 citations

Heart Disease and Stroke Statistics—2009 Update

2008 • 3,119 citations

Effect of Carvedilol on Survival in Severe Chronic Heart Failure

2001 • 3,011 citations

A Comparison of Enalapril with Hydralazine–Isosorbide Dinitrate in the Treatment of Chronic Congestive Heart Failure

1991 • 2,867 citations

ACC/AHA 2005 Guideline Update for the Diagnosis and Management of Chronic Heart Failure in the Adult

2005 • 2,255 citations

Heart Rate, Life Expectancy and the Cardiovascular System: Therapeutic Considerations

2015 • 1,908 citations

Effect of ramipril on mortality and morbidity of survivors of acute myocardial infarction with clinical evidence of heart failure

1993 • 1,775 citations

Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: the CAPRICORN randomised trial

2001 • 1,774 citations

Overview of randomized trials of angiotensin-converting enzyme inhibitors on mortality and morbidity in patients with heart failure. Collaborative Group on ACE Inhibitor Trials

1995 • 1,526 citations

Overview of Randomized Trials of Angiotensin-Converting Enzyme Inhibitors on Mortality and Morbidity in Patients With Heart Failure

1995 • 1,301 citations

Effect of Carvedilol on the Morbidity of Patients With Severe Chronic Heart Failure

2002 • 1,287 citations

A double‐blind, placebo‐controlled trial

1986 • 1,281 citations

Effect of ramipril on mortality and morbidity of survivors of acute myocardial infarction with clinical evidence of heart failure. The Acute Infarction Ramipril Efficacy (AIRE) Study Investigators.

1993 • 1,240 citations

Beneficial effects of metoprolol in idiopathic dilated cardiomyopathy

1993 • 1,218 citations

Comparative Effects of Low and High Doses of the Angiotensin-Converting Enzyme Inhibitor, Lisinopril, on Morbidity and Mortality in Chronic Heart Failure

1999 • 1,194 citations

Prospective Study of Heart Rate Variability and Mortality in Chronic Heart Failure

1998 • 1,142 citations

A randomized trial of beta-blockade in heart failure. The Cardiac Insufficiency Bisoprolol Study (CIBIS). CIBIS Investigators and Committees.

1994 • 1,051 citations

Altered expression of beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart.

1993 • 877 citations

Digoxin in Heart Failure with a Reduced Ejection Fraction: A Risk Factor or a Risk Marker?

2016 • 872 citations

Myocardial Iodine-123 Meta-Iodobenzylguanidine Imaging and Cardiac Events in Heart Failure

2010 • 814 citations

Long-term beta-blockade in dilated cardiomyopathy. Effects of short- and long-term metoprolol treatment followed by withdrawal and readministration of metoprolol.

1989 • 447 citations

Captopril in heart failure. A double blind controlled trial.

1984 • 385 citations

Enalapril in patients with chronic heart failure: a placebo-controlled, randomized, double-blind study.

1984 • 267 citations

Contrasting peripheral short-term and long-term effects of converting enzyme inhibition in patients with congestive heart failure. A double-blind, placebo-controlled trial.

1989 • 246 citations

Abnormal Awake Respiratory Patterns Are Common in Chronic Heart Failure and May Prevent Evaluation of Autonomic Tone by Measures of Heart Rate Variability

1997 • 214 citations

I-123-mIBG myocardial imaging for assessment of risk for a major cardiac event in heart failure patients: insights from a retrospective European multicenter study

2007 • 210 citations

Cardiac Sympathetic Imaging With mIBG in Heart Failure

2010 • 188 citations

Clinical outcome with enalapril in symptomatic chronic heart failure; a dose comparison

1998 • 185 citations

Effect of spironolactone on cardiacsympathetic nerve activity and left ventricular remodeling in patients with dilated cardiomyopathy

2003 • 148 citations

Comparison of the prognostic value of cardiac iodine-123 metaiodobenzylguanidine imaging and heart rate variability in patients with chronic heart failure

2003 • 146 citations

Influence of pretreatment systolic blood pressure on the effect of carvedilol in patients with severe chronic heart failure

2004 • 144 citations

Iodine-123 metaiodobenzylguanidine myocardial scintigraphy for prediction of response to β-blocker therapy in patients with dilated cardiomyopathy

1997 • 130 citations

Effects of candesartan on cardiac sympathetic nerve activity in patients with congestive heart failure and preserved left ventricular ejection fraction

2005 • 119 citations

Mechanisms of Disease: β-adrenergic receptors—alterations in signal transduction and pharmacogenomics in heart failure

2005 • 116 citations

Clinical importance of the renin-angiotensin system in chronic heart failure: double blind comparison of captopril and prazosin.

1985 • 114 citations

ACE inhibition reduces cardiac iodine-123-MIBG release in heart failure.

1997 • 113 citations

Improvement of cardiac neuronal function after carvedilol treatment in dilated cardiomyopathy: a 123I-MIBG scintigraphic study.

2000 • 107 citations

Effect of Spironolactone on Cardiac Sympathetic Nerve Activity and Left Ventricular Remodeling in Patients with Dilated Cardiomyopathy

2003 • 105 citations

Normal values and within-subject variability of cardiac I-123 MIBG scintigraphy in healthy individuals: implications for clinical studies

2004 • 104 citations

Measurement of sympathetic nervous system activity in heart failure: the role of norepinephrine kinetics.

2000 • 104 citations

Carvedilol improves left ventricular function in heart failure patients with idiopathic dilated cardiomyopathy and a wide range of sympathetic nervous system function as measured by iodine 123 metaiodobenzylguanidine

2002 • 91 citations

Evaluation of cardiac sympathetic nerve activity and left ventricular remodelling in patients with dilated cardiomyopathy on the treatment containing carvedilol

2007 • 88 citations

Meta-analysis of observed mortality data from all-controlled, double-blind, multiple-dose studies of losartan in heart failure

2000 • 85 citations

Limitations of the use of spectral analysis of heart rate variability for the estimation of cardiac sympathetic activity in heart failure

2001 • 82 citations

Clinical outcome with enalapril in symptomatic chronic heart failure; a dose comparison The NETWORK investigators

1998 • 79 citations

Outcome of patients with congestive heart failure treated with standard versus high doses of enalapril: a multicenter study

2000 • 76 citations

Use of iodine-123 metaiodobenzylguanidine myocardial imaging to predict the effectiveness of ?-blocker therapy in patients with dilated cardiomyopathy

1997 • 60 citations

Prognostic Value of Iodine-123-Metaiodobenzylguanidine Myocardial Uptake and Heart Rate Variability in Chronic Congestive Heart Failure Secondary to Ischemic or Idiopathic Dilated Cardiomyopathy

2005 • 56 citations

Effects of carvedilol on myocardial sympathetic innervation in patients with chronic heart failure.

2005 • 53 citations

Captopril in heart failure.

1988 • 50 citations

Clinical Outcomes According to Baseline Blood Pressure in Patients With a Low Ejection Fraction in the CHARM (Candesartan in Heart failure: Assessment of Reduction in Mortality and morbidity) Program

2008 • 46 citations

Guideline adherence for pharmacotherapy of chronic systolic heart failure in general practice: a closer look on evidence-based therapy

2007 • 44 citations

Will Imaging Assist in the Selection of Patients With Heart Failure for an ICD?

2010 • 24 citations

Long-term effects of clinical outcome with low and high dose in the Captopril in Heart Insufficient Patients Study (CHIPS)

2000 • 20 citations

ACE inhibitor dosage at the time of listing predicts survival

2000 • 16 citations

The early anti-oxidant effect of carvedilol predicts the clinical course in congestive heart failure patients

2007 • 13 citations