Limitations of the use of spectral analysis of heart rate variability for the estimation of cardiac sympathetic activity in heart failure

Heart Rate Variability

1996 • 15,997 citations

Heart rate variability: Standards of measurement, physiological interpretation, and clinical use

1996 • 14,140 citations

Power Spectrum Analysis of Heart Rate Fluctuation: A Quantitative Probe of Beat-to-Beat Cardiovascular Control

1981 • 4,922 citations

Power spectral analysis of heart rate and arterial pressure variabilities as a marker of sympatho-vagal interaction in man and conscious dog.

1986 • 4,114 citations

Cardiovascular neural regulation explored in the frequency domain.

1991 • 3,551 citations

Plasma Norepinephrine as a Guide to Prognosis in Patients with Chronic Congestive Heart Failure

1984 • 3,130 citations

Baroreflex sensitivity and heart-rate variability in prediction of total cardiac mortality after myocardial infarction

1998 • 3,050 citations

Assessment of autonomic function in humans by heart rate spectral analysis

1985 • 2,846 citations

Frequency domain measures of heart period variability and mortality after myocardial infarction.

1992 • 1,702 citations

Comparison of neuroendocrine activation in patients with left ventricular dysfunction with and without congestive heart failure. A substudy of the Studies of Left Ventricular Dysfunction (SOLVD).

1990 • 1,397 citations

Prospective Study of Heart Rate Variability and Mortality in Chronic Heart Failure

1998 • 1,142 citations

Sympathovagal Balance

1997 • 1,067 citations

Norepinephrine spillover to plasma in patients with congestive heart failure: evidence of increased overall and cardiorenal sympathetic nervous activity.

1986 • 1,025 citations

Controlled trial of physical training in chronic heart failure. Exercise performance, hemodynamics, ventilation, and autonomic function.

1992 • 963 citations

Relationship Between Spectral Components of Cardiovascular Variabilities and Direct Measures of Muscle Sympathetic Nerve Activity in Humans

1997 • 869 citations

Direct evidence from intraneural recordings for increased central sympathetic outflow in patients with heart failure.

1986 • 815 citations

Important influence of respiration on human R-R interval power spectra is largely ignored

1993 • 755 citations

Assessment of autonomic regulation in chronic congestive heart failure by heart rate spectral analysis

1988 • 726 citations

Adverse consequences of high sympathetic nervous activity in the failing human heart

1995 • 666 citations

Effects of Continuous Positive Airway Pressure on Cardiovascular Outcomes in Heart Failure Patients With and Without Cheyne-Stokes Respiration

2000 • 641 citations

Depressed Heart Rate Variability as an Independent Predictor of Death in Chronic Congestive Heart Failure Secondary to Ischemic or Idiopathic Dilated Cardiomyopathy

1997 • 494 citations

How to assess sympathetic activity in humans

1999 • 445 citations

Cardiac Sympathetic Nerve Function in Congestive Heart Failure

1996 • 442 citations

Heart rate spectral analysis, cardiac norepinephrine spillover, and muscle sympathetic nerve activity during human sympathetic nervous activation and failure.

1994 • 407 citations

Power Law Behavior of RR-Interval Variability in Healthy Middle-Aged Persons, Patients With Recent Acute Myocardial Infarction, and Patients With Heart Transplants

1996 • 390 citations

Absence of Low-Frequency Variability of Sympathetic Nerve Activity in Severe Heart Failure

1997 • 378 citations

Parasympathetic withdrawal is an integral component of autonomic imbalance in congestive heart failure: Demonstration in human subjects and verification in a paced canine model of ventricular failure

1991 • 365 citations

Coarse-graining spectral analysis: new method for studying heart rate variability

1991 • 360 citations

Analysis of short-term oscillations of R-R and arterial pressure in conscious dogs

1990 • 355 citations

Heart rate and muscle sympathetic nerve variability during reflex changes of autonomic activity

1990 • 345 citations

Increased Cardiac Adrenergic Drive Precedes Generalized Sympathetic Activation in Human Heart Failure

1997 • 311 citations

Clinical and hemodynamic correlates of sympathetic nerve activity in normal humans and patients with heart failure: Evidence from direct micronenrographic recordings

1990 • 264 citations

Clinical, hemodynamic and sympathetic neural correlates of heart rate variability in congestive heart failure

1992 • 252 citations

Autonomic pathophysiology in heart failure patients. Sympathetic-cholinergic interrelations.

1990 • 218 citations

Abnormal Awake Respiratory Patterns Are Common in Chronic Heart Failure and May Prevent Evaluation of Autonomic Tone by Measures of Heart Rate Variability

1997 • 214 citations

Oscillatory Breathing Patterns During Wakefulness in Patients With Chronic Heart Failure

1999 • 205 citations

Reversal of autonomic derangements by physical training in chronic heart failure assessed by heart rate variability

1995 • 203 citations

Autonomic control of heart rate during physical exercise and fractal dimension of heart rate variability

1993 • 198 citations

Heart Rate Variability at Rest and Exercise: Influence of Age, Gender, and Physical Training

1996 • 180 citations

Pitfalls in the interpretation of spectral analysis of the heart rate variability during exercise in humans

1995 • 168 citations

Pulmonary and peripheral vascular factors are important determinants of peak exercise oxygen uptake in patients with heart failure

1993 • 152 citations

Endogenous catecholamine levels in chronic heart failure. Relation to the severity of hemodynamic abnormalities

1985 • 141 citations

Can power spectral analysis of heart rate variability identify a high risk subgroup of congestive heart failure patients with excessive sympathetic activation? A pilot study before and after heart transplantation.

1994 • 138 citations

Sympathetic predominance followed by functional denervation in the progression of chronic heart failure

1995 • 138 citations

Prognostic Value of Heart Rate Variability in Chronic Congestive Heart Failure Secondary to Idiopathic or Ischemic Dilated Cardiomyopathy

1997 • 137 citations

Acute Effects of β ₁ -Selective and Nonselective β-Adrenergic Receptor Blockade on Cardiac Sympathetic Activity in Congestive Heart Failure

1996 • 117 citations

Effects of age on intrinsic heart rate, heart rate variability, and AV conduction in healthy humans

1995 • 110 citations

Current clinical applications of heart rate variability

1998 • 107 citations

Heart rate variability and fractal dimension during orthostatic challenges

1993 • 107 citations

Ganglionic Mechanisms Contribute to Diminished Vagal Control in Heart Failure

1999 • 105 citations

Reducing Cardiac Filling Pressure Lowers Norepinephrine Spillover in Patients With Chronic Heart Failure

2000 • 102 citations

Spectral analysis of sympathetic discharge, R-R interval and systolic arterial pressure in decerebrate cats

1992 • 96 citations

Time course of sympathovagal imbalance and left ventricular dysfunction in conscious dogs with heart failure

1998 • 95 citations

Comparison of different methods for assessing sympathovagal balance in chronic congestive heart failure secondary to coronary artery disease

1992 • 90 citations

Impact of Changes in Respiratory Frequency and Posture on Power Spectral Analysis of Heart Rate and Systolic Blood Pressure Variability in Normal Subjects and Patients with Heart Failure

1996 • 89 citations

Role of beta-adrenergic receptor downregulation in the peak exercise response in patients with heart failure due to idiopathic dilated cardiomyopathy

1995 • 89 citations

Heart rate variability in left ventricular dysfunction and heart failure: effects and implications of drug treatment.

1994 • 83 citations

Parasympathetic Control of Cardiac Sympathetic Activity

1999 • 83 citations

Dissociation between microneurographic and heart rate variability estimates of sympathetic tone in normal subjects and patients with heart failure

1999 • 81 citations

Effect of autonomic blockade on power spectrum of heart rate variability during exercise

1997 • 81 citations

Contribution to Heart Rate Variability by Mechanoelectric Feedback

1996 • 79 citations

Resting muscle sympathetic nerve activity and peak oxygen uptake in heart failure and normal subjects

1999 • 75 citations

Frequency domain characteristics of muscle sympathetic nerve activity in heart failure and healthy humans

1997 • 74 citations

Early Left Ventricular Dysfunction Elicits Activation of Sympathetic Drive and Attenuation of Parasympathetic Tone in the Paced Canine Model of Congestive Heart Failure

1995 • 70 citations

Physical Training Enhances Sympathetic and Parasympathetic Control of Heart Rate and Peripheral Vessels in Chronic Heart Failure

1996 • 70 citations

Continuous positive airway pressure increases heart rate variability in congestive heart failure

1995 • 68 citations

Long-term β-blocker therapy improves autonomic nervous regulation in advanced congestive heart failure: A longitudinal heart rate variability study

1999 • 67 citations

Detection and significance of a discrete very low frequency rhythm in RR interval variability in chronic congestive heart failure

1996 • 60 citations

Low-frequency components of cardiovascular variabilities as markers of sympathetic modulation

1992 • 59 citations

Fractal Electrodynamics of the Heartbeat^a

1990 • 55 citations

Heart rate variability and cardiac failure

1998 • 55 citations

Relation between severity of disease and impairment of heart rate variability parameters in patients with chronic congestive heart failure secondary to coronary artery disease

1995 • 54 citations

Fractal Component of Variability of Heart Rate and Systolic Blood Pressure in Congestive Heart Failure

1997 • 54 citations

Role of spectral measures of heart rate variability as markers of disease progression in patients with chronic congestive heart failure not treated with angiotensin-converting enzyme inhibitors

1996 • 53 citations

Muscarinic receptor modulation of basal and beta-adrenergic stimulated function of the failing human left ventricle.

1996 • 52 citations

Chemoreceptor dependence of very low frequency rhythms in advanced chronic heart failure

1997 • 46 citations

Is heart rate variability a reliable method to assess autonomic modulation in left ventricular dysfunction and heart failure?

1998 • 44 citations

After-effects of exercise on haemodynamics and muscle sympathetic nerve activity in young patients with dilated cardiomyopathy.

1996 • 43 citations

Effects of enalapril on heart rate variability in patients with congestive heart failure

1995 • 38 citations

Functional Significance of Presynaptic α-Adrenergic Receptors in Failing and Nonfailing Human Left Ventricle

1995 • 36 citations

Sympathetic Rhythmicity in Cardiac Transplant Recipients

1999 • 32 citations

Dissociation between microneurographic and heart rate variability estimates of sympathetic tone in normal subjects and patients with heart failure

1999 • 32 citations

Normalization of total body and regional sympathetic hyperactivity in heart failure after heart transplantation.

1996 • 31 citations

Modulation of in situ canine intrinsic cardiac neuronal activity by nicotinic, muscarinic, and beta-adrenergic agonists

1993 • 30 citations

Repeatability of Spectral Components of Short-Term Blood Pressure and Heart Rate Variability during Acute Sympathetic Activation in Healthy Young Male Subjects

1997 • 27 citations

Catecholamines, Renin-Angiotensin-Aldosterone System, and Atrial Natriuretic Peptide at Rest and During Submaximal Exercise in Patients With Congestive Heart Failure

1996 • 25 citations

Effect of clonidine on heart rate variability in congestive heart failure

1998 • 22 citations

Low-Dose But Not High-Dose Captopril Increases Parasympathetic Activity in Patients with Heart Failure

1997 • 18 citations

Catecholamines, Renin-Angiotensin-Aldosterone System, and Atrial Natriuretic Peptide at Rest and During Submaximal Exercise in Patients With Congestive Heart Failure

1996 • 11 citations

Reversal of Autonomic Derangements by Physical Training in Chronic Heart Failure Assessed by Heart Rate Variability

1996 • 8 citations

Influence of Exercise Training and Restriction of Activity on Autonomic Balance in Patients with Severe Congestive Heart Failure

1996 • 8 citations

Sympathetic Stimulations by Exercise-Stress Testing and by Dobutamine Infusion Induce Similar Changes in Heart Rate Variability in Patients with Chronic Heart Failure

1995 • 8 citations

Heart Rate Variability and Autonomic Balance in Patients with Different Stages of Severe Congestive Heart Failure

1996 • 3 citations

Role of spectral measures of heart rate variability as markers of disease progression in patients with chronic congestive heart failure not treated with angiotensin-converting enzyme inhibitors

1997 • 1 citations