Unexpected heterogeneity of BCR-ABL fusion mRNA detected by polymerase chain reaction in Philadelphia chromosome-positive acute lymphoblastic leukemia.

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

[21] Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction

1987 • 5,745 citations

A New Consistent Chromosomal Abnormality in Chronic Myelogenous Leukaemia identified by Quinacrine Fluorescence and Giemsa Staining

1973 • 4,217 citations

Purification of Mouse Immunoglobulin Heavy‐Chain Messenger RNAs from Total Myeloma Tumor RNA

1980 • 2,696 citations

Fused transcript of abl and bcr genes in chronic myelogenous leukaemia

1985 • 1,650 citations

Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22

1984 • 1,644 citations

Structural organization of the bcr gene and its role in the Ph′ translocation

1985 • 920 citations

Diagnosis of chronic myeloid and acute lymphocytic leukemias by detection of leukemia-specific mRNA sequences amplified in vitro.

1988 • 741 citations

Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene

1986 • 489 citations

A novel abl protein expressed in Philadelphia chromosome positive acute lymphoblastic leukaemia positive acute lymphoblastic leukaemia

1987 • 448 citations

Unique fusion of bcr and c-abl genes in Philadelphia chromosome positive acute lymphoblastic leukemia

1987 • 405 citations

Unique Forms of the abl Tyrosine Kinase Distinguish Ph ¹ -Positive CML from Ph ¹ -Positive ALL

1987 • 344 citations

Cell lines and clinical isolates derived from Ph1-positive chronic myelogenous leukemia patients express c-abl proteins with a common structural alteration.

1985 • 282 citations

A novel c-abl protein product in Philadelphia-positive acute lymphoblastic leukaemia

1987 • 278 citations

Expression of a Distinctive BCR-ABL Oncogene in Ph ¹ -Positive Acute Lymphocytic Leukemia (ALL)

1988 • 252 citations

Chronic myelogenous leukemia: recent advances

1985 • 247 citations

A new fused transcript in Philadelphia chromosome positive acute lymphocytic leukaemia

1987 • 201 citations

bcr rearrangement and translocation of the c-abl oncogene in Philadelphia positive acute lymphoblastic leukemia

1986 • 186 citations

Chromosome Abnormalities in Malignant Hematologic Diseases

1982 • 180 citations

The first intron in the human c-abl gene is at least 200 kilobases long and is a target for translocations in chronic myelogenous leukemia.

1987 • 179 citations

Heterogeneity of chromosome 22 breakpoint in Philadelphia-positive (Ph+) acute lymphocytic leukemia.

1986 • 160 citations

Ph¹‐POSITIVE ACUTE LEUKAEMIA AND CHRONIC GRANULOCYTIC LEUKAEMIA: ONE OR TWO DISEASES?

1979 • 142 citations

Overlapping cDNA clones define the complete coding region for the P210c-abl gene product associated with chronic myelogenous leukemia cells containing the Philadelphia chromosome.

1986 • 138 citations

Novel chimaeric protein expressed in Philadelphia positive acute lymphoblastic leukaemia

1987 • 102 citations

Expression of c-abl in Philadelphia-positive acute myelogenous leukemia

1987 • 89 citations

Variable Philadelphia breakpoints and potential lineage restriction of bcr rearrangement in acute lymphoblastic leukemia

1988 • 61 citations

Long-range mapping of the Philadelphia chromosome by pulsed-field gel electrophoresis

1988 • 61 citations

Identification of molecular variants of p210bcr-abl in chronic myelogenous leukemia

1987 • 59 citations

Variable breakpoints on the Philadelphia chromosome in chronic myelogenous leukemia

1985 • 58 citations

Philadelphia-negative chronic myelogenous leukemia with breakpoint cluster region rearrangement: molecular analysis, clinical characteristics, and response to therapy.

1988 • 51 citations

Heterogeneity of genomic fusion of BCR and ABL in Philadelphia chromosome-positive acute lymphoblastic leukemia.

1988 • 51 citations

The Third International Workshop on Chromosomes in Leukemia

1981 • 45 citations

Utility of molecular genetic analysis of bcr rearrangement in the diagnosis of chronic myeloid leukemia

1987 • 33 citations

The First Intron in the Human c-abl Gene Is at Least 200 Kilobases Long and Is a Target for Translocations in Chronic Myelogenous Leukemia

1987 • 31 citations

Additional c-abl/bcr rearrangements in a CML patient exhibiting two Ph1 chromosomes during blast crisis

1986 • 30 citations