The First Intron in the Human c-abl Gene Is at Least 200 Kilobases Long and Is a Target for Translocations in Chronic Myelogenous Leukemia

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1984 • 4,899 citations

Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes

1986 • 4,785 citations

A New Consistent Chromosomal Abnormality in Chronic Myelogenous Leukaemia identified by Quinacrine Fluorescence and Giemsa Staining

1973 • 4,217 citations

Separation of yeast chromosome-sized DNAs by pulsed field gradient gel electrophoresis

1984 • 2,847 citations

Fused transcript of abl and bcr genes in chronic myelogenous leukaemia

1985 • 1,650 citations

Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22

1984 • 1,644 citations

The promoter-specific transcription factor Sp1 binds to upstream sequences in the SV40 early promoter

1983 • 1,471 citations

An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity

1984 • 913 citations

Separation of chromosomal DNA molecules from yeast by orthogonal-field-alternation gel electrophoresis

1984 • 887 citations

Localization of the c-abl oncogene adjacent to a translocation break point in chronic myelocytic leukaemia

1983 • 848 citations

Three regions upstream from the cap site are required for efficient and accurate transcription of the rabbit β-globin gene in mouse 3T6 cells

1983 • 596 citations

Abelson murine leukaemia virus protein is phosphorylated in vitro to form phosphotyrosine

1980 • 539 citations

Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene

1986 • 489 citations

Structure of the Abelson murine leukemia virus genome and the homologous cellular gene: Studies with cloned viral DNA

1980 • 474 citations

DISCONTINUOUS TRANSCRIPTION AND ANTIGENIC VARIATION IN TRYPANOSOMES

1986 • 418 citations

Alternative 5′ exons in c-abl mRNA

1986 • 290 citations

Gene within a gene: Nested Drosophila genes encode unrelated proteins on opposite DNA strands

1986 • 251 citations

Rearrangement and amplification of c-abl sequences in the human chronic myelogenous leukemia cell line K-562.

1983 • 244 citations

An 8-kilobase abl RNA transcript in chronic myelogenous leukemia.

1984 • 210 citations

Two Mammalian Genes Transcribed from Opposite Strands of the Same DNA Locus

1987 • 195 citations

Evidence for in vivo trans splicing of pre-mRNAs in tobacco chloroplasts

1987 • 138 citations

The chronic myelocytic cell line K562 contains a breakpoint in bcr and produces a chimeric bcr/c-abl transcript.

1986 • 128 citations

Amplified C lambda and c-abl genes are on the same marker chromosome in K562 leukemia cells.

1983 • 92 citations

Drosophila melanogaster DNA clones homologous to vertebrate oncogenes: Evidence for a common ancestor to the src and abl cellular genes

1983 • 91 citations

Homology between phosphotyrosine acceptor site of human c-abl and viral oncogene products

1983 • 86 citations

Pulsed field gradient electrophoresis of DNA digested in agarose allows the sizing of the large duplication unit of a surface antigen gene in trypanosomes

1986 • 66 citations

Cellular RNA Homologous to the Abelson Murine Leukemia Virus Transforming Gene: Expression and Relationship to the Viral Sequence

1983 • 42 citations