Higher-order organization and regulation of adenylyl cyclases

The role of hormone receptors and GTP-regulatory proteins in membrane transduction

1980 • 1,750 citations

A Role for Lipid Shells in Targeting Proteins to Caveolae, Rafts, and Other Lipid Domains

2002 • 1,130 citations

AKAP signalling complexes: focal points in space and time

2004 • 1,055 citations

Complexity and Diversity of Mammalian Adenylyl Cyclases

1996 • 857 citations

Unbiased quantitative proteomics of lipid rafts reveals high specificity for signaling factors

2003 • 839 citations

Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms

2002 • 754 citations

Requirement of a Macromolecular Signaling Complex for β Adrenergic Receptor Modulation of the KCNQ1-KCNE1 Potassium Channel

2002 • 702 citations

Lipid rafts: heterogeneity on the high seas

2004 • 689 citations

Regulation of Cardiac L-Type Calcium Channels by Protein Kinase A and Protein Kinase C

2000 • 592 citations

The ABC transporter structure and mechanism: perspectives on recent research

2004 • 557 citations

The protein kinase A anchoring protein mAKAP coordinates two integrated cAMP effector pathways

2005 • 542 citations

Differential Targeting of β-Adrenergic Receptor Subtypes and Adenylyl Cyclase to Cardiomyocyte Caveolae

2000 • 514 citations

A β ₂ Adrenergic Receptor Signaling Complex Assembled with the Ca ²⁺ Channel Ca _v 1.2

2001 • 509 citations

Emerging role of homo- and heterodimerization in G-protein-coupled receptor biosynthesis and maturation

2005 • 435 citations

Compartments of cyclic AMP and protein kinase in mammalian cardiomyocytes.

1983 • 428 citations

Assembly of Trp1 in a Signaling Complex Associated with Caveolin-Scaffolding Lipid Raft Domains

2000 • 403 citations

The evolving role of lipid rafts and caveolae in G protein‐coupled receptor signaling: implications for molecular pharmacology

2004 • 394 citations

Localization of cardiac L-type Ca ²⁺ channels to a caveolar macromolecular signaling complex is required for β ₂ -adrenergic regulation

2006 • 386 citations

The cellular and molecular basis of store-operated calcium entry

2002 • 366 citations

The Endothelial Nitric-oxide Synthase-Caveolin Regulatory Cycle

1998 • 357 citations

Regulation and organization of adenylyl cyclases and cAMP

2003 • 354 citations

A uniform extracellular stimulus triggers distinct cAMP signals in different compartments of a simple cell

2001 • 282 citations

RGS2 regulates signal transduction in olfactory neurons by attenuating activation of adenylyl cyclase III

2001 • 260 citations

Receptor Number and Caveolar Co-localization Determine Receptor Coupling Efficiency to Adenylyl Cyclase

2001 • 254 citations

Differential Targeting of Shaker-like Potassium Channels to Lipid Rafts

2000 • 249 citations

Identification of Reggie-1 and Reggie-2 as plasmamembrane-associated proteins which cocluster with activated GPI-anchored cell adhesion molecules in non-caveolar micropatches in neurons

1998 • 240 citations

Caveolar Localization Dictates Physiologic Signaling of β2-Adrenoceptors in Neonatal Cardiac Myocytes

2002 • 236 citations

G Protein-coupled Receptors Form Stable Complexes with Inwardly Rectifying Potassium Channels and Adenylyl Cyclase

2002 • 194 citations

An anchored PKA and PDE4 complex regulates subplasmalemmal cAMP dynamics

2006 • 182 citations

Functional Co-localization of Transfected Ca2+-stimulable Adenylyl Cyclases with Capacitative Ca2+ Entry Sites

1996 • 168 citations

Modification of the calcium and calmodulin sensitivity of the type I adenylyl cyclase by mutagenesis of its calmodulin binding domain.

1993 • 155 citations

Stabilization of Cortical Actin Induces Internalization of Transient Receptor Potential 3 (Trp3)-associated Caveolar Ca2+ Signaling Complex and Loss of Ca2+ Influx without Disruption of Trp3-Inositol Trisphosphate Receptor Association

2001 • 144 citations

Negative Feedback Exerted by cAMP-dependent Protein Kinase and cAMP Phosphodiesterase on Subsarcolemmal cAMP Signals in Intact Cardiac Myocytes

2004 • 137 citations

Arrestin times for compartmentalised cAMP signalling and phosphodiesterase-4 enzymes

2005 • 131 citations

Regulation of the Ca2+-inhibitable Adenylyl Cyclase Type VI by Capacitative Ca2+ Entry Requires Localization in Cholesterol-rich Domains

2000 • 128 citations

Truncation and Alanine-Scanning Mutants of Type I Adenylyl Cyclase

1995 • 127 citations

Adenylate cyclases: critical foci in neuronal signaling

1995 • 125 citations

Complexes of the α1C and β Subunits Generate the Necessary Signal for Membrane Targeting of Class C L-type Calcium Channels

1999 • 123 citations

Colocalization of ?-adrenergic receptors and caveolin within the plasma membrane

1999 • 108 citations

Inhibition of Adenylyl Cyclase by Caveolin Peptides*

1998 • 106 citations

Assembly of a Ca2+-dependent BK channel signaling complex by binding to β2 adrenergic receptor

2004 • 102 citations

Nitric Oxide Inhibition of Adenylyl Cyclase Type 6 Activity Is Dependent upon Lipid Rafts and Caveolin Signaling Complexes

2004 • 101 citations

Residence of Adenylyl Cyclase Type 8 in Caveolae Is Necessary but Not Sufficient for Regulation by Capacitative Ca2+Entry

2002 • 93 citations

Calmodulin-binding Sites on Adenylyl Cyclase Type VIII

1999 • 89 citations

Persistent membrane association of activated and depalmitoylated G protein α subunits

1999 • 87 citations

The Cytosolic Domains of Ca2+-sensitive Adenylyl Cyclases Dictate Their Targeting to Plasma Membrane Lipid Rafts

2004 • 86 citations

Discriminating between Capacitative and Arachidonate-activated Ca2+ Entry Pathways in HEK293 Cells

1999 • 85 citations

Functional Role of Lipid Raft Microdomains in Cyclic Nucleotide-Gated Channel Activation

2004 • 85 citations

Regulators of G-protein Signaling Form a Quaternary Complex with the Agonist, Receptor, and G-protein

2005 • 75 citations

Ca(2+)-sensitive adenylyl cyclases.

1998 • 73 citations

Persistent interactions between the two transmembrane clusters dictate the targeting and functional assembly of adenylyl cyclase

2001 • 68 citations

2 Ca2+-sensitive adenylyl cyclases

1997 • 63 citations

Modeling of Gαs and Gαi Regulation of Human Type V and VI Adenylyl Cyclase

2004 • 60 citations

Dimerization of mammalian adenylate cyclases

2002 • 52 citations

A Critical Interplay between Ca2+ Inhibition and Activation by Mg2+ of AC5 Revealed by Mutants and Chimeric Constructs

2002 • 50 citations

Increase in the size of soluble brain adenylate cyclase with activation by guanosine 5'-(beta, gamma-imino)triphosphate.

1980 • 48 citations

A Possible Role for Caveolin as a Signaling Organizer in Olfactory Sensory Membranes

2000 • 46 citations

Regulation of Type VI Adenylyl Cyclase by Snapin, a SNAP25-binding Protein

2004 • 45 citations

A Direct Interaction between the N Terminus of Adenylyl Cyclase AC8 and the Catalytic Subunit of Protein Phosphatase 2A

2005 • 44 citations

An isoform–specific interaction of the membrane anchors affects mammalian adenylyl cyclase type V activity

2001 • 31 citations

Inhibition of Adenylyl Cyclase by Caveolin Peptides

1998 • 22 citations

Isoform-Specific Regulation of Adenylyl Cyclase Function by Disruption of Membrane Trafficking

2004 • 14 citations