Cellular Islet Autoimmunity Associates with Clinical Outcome of Islet Cell Transplantation

Islet Transplantation in Seven Patients with Type 1 Diabetes Mellitus Using a Glucocorticoid-Free Immunosuppressive Regimen

2000 • 5,125 citations

International Trial of the Edmonton Protocol for Islet Transplantation

2006 • 1,869 citations

Five-Year Follow-Up After Clinical Islet Transplantation

2005 • 1,606 citations

Type 1 diabetes: new perspectives on disease pathogenesis and treatment

2001 • 1,477 citations

Significance of the Positive Crossmatch Test in Kidney Transplantation

1969 • 1,453 citations

Determinant spreading and the dynamics of the autoimmune T-cell repertoire

1993 • 467 citations

C-Peptide Is the Appropriate Outcome Measure for Type 1 Diabetes Clinical Trials to Preserve β-Cell Function

2004 • 456 citations

Combined use of autoantibodies (IA-2 autoantibody, GAD autoantibody, insulin autoantibody, cytoplasmic islet cell antibodies) in type 1 diabetes: Combinatorial Islet Autoantibody Workshop.

1998 • 424 citations

The role of T-cells in the pathogenesis of Type 1 diabetes: From cause to cure

2003 • 410 citations

Recurrent diabetes mellitus in the pancreas iso- and allograft. A light and electron microscopic and immunohistochemical analysis of four cases.

1985 • 387 citations

Transplantation of Cultured Islets from Two-Layer Preserved Pancreases in Type 1 Diabetes with Anti-CD3 Antibody

2004 • 367 citations

Immunosuppression with Azathioprine and Prednisone in Recent-Onset Insulin-Dependent Diabetes Mellitus

1988 • 304 citations

Autoreactive CD8 T cells associated with β cell destruction in type 1 diabetes

2005 • 275 citations

Graft vascular function after transplantation of pancreatic islets

2002 • 274 citations

Development of Type 1 Diabetes despite Severe Hereditary B-Cell Deficiency

2001 • 251 citations

Recurrence of Disease in Pancreas Transplants

1989 • 241 citations

Humoral theory of transplantation: further evidence

2005 • 190 citations

Recurrence of Autoimmune Diabetes Mellitus in Recipients of Cadaveric Pancreatic Grafts

1996 • 183 citations

Challenges facing islet transplantation for the treatment of type 1 diabetes mellitus

2004 • 183 citations

Auto- and alloimmune reactivity to human islet allografts transplanted into type 1 diabetic patients.

1999 • 183 citations

Challenges facing islet transplantation for the treatment of type 1 diabetes mellitus

2004 • 173 citations

Correlation between β cell mass and glycemic control in type 1 diabetic recipients of islet cell graft

2006 • 171 citations

Limited Duration of Remission of Insulin Dependency in Children With Recent Overt Type I Diabetes Treated With Low-Dose Cyclosporin

1990 • 168 citations

T-Cell Responses to Autoantigens in IDDM: The Search for the Holy Grail

1996 • 164 citations

Implantation of standardized beta-cell grafts in a liver segment of IDDM patients: graft and recipient characteristics in two cases of insulin-independence under maintenance immunosuppression for prior kidney graft

1998 • 156 citations

Integrin Signaling via RGD Peptides and Anti-β1 Antibodies Confers Resistance to Apoptosis in Islets of Langerhans

2006 • 152 citations

Pancreas Transplantation for Treatment of Diabetes Mellitus

2001 • 131 citations

Autoantibody Response to Islet Transplantation in Type 1 Diabetes

2001 • 126 citations

Anti-thymocyte globulin and prednisone immunotherapy of recent onset type 1 diabetes mellitus.

1985 • 126 citations

Pancreatic Islet Transplantation

2004 • 121 citations

High frequency of persisting or increasing islet-specific autoantibody levels after diagnosis of type 1 diabetes presenting before 40 years of age. The Belgian Diabetes Registry.

2000 • 105 citations

Progressive Islet Graft Failure Occurs Significantly Earlier in Autoantibody-Positive Than in Autoantibody-Negative IDDM Recipients of Intrahepatic Islet Allografts

1997 • 98 citations

Modulation of humoral islet autoimmunity by pancreas allotransplantation influences allograft outcome in patients with type 1 diabetes.

2000 • 91 citations

T-Cell Reactivity to β-Cell Membrane Antigens Associated With β-Cell Destruction in IDDM

1995 • 83 citations

Computer aided design and evaluation of limiting and serial dilution experiments

1988 • 80 citations

Characterization of Preparations of GAD65, Proinsulin, and the Islet Tyrosine Phosphatase IA-2 for Use in Detection of Autoreactive T-Cells in Type 1 Diabetes

2001 • 79 citations

Islet Transplantation in Patients with Diabetes Mellitus

2004 • 65 citations

Determination of cytotoxic T-lymphocyte precursor frequencies using europium labeling as a nonradioactive alternative to labeling with chromium-51

1992 • 61 citations

Prevention of autoimmune recurrence and rejection by adenovirus-mediated CTLA4Ig gene transfer to the pancreatic graft in BB rat.

1999 • 47 citations

SUCCESSFUL LONG-TERM KIDNEY-PANCREAS TRANSPLANTS IN DIABETIC PATIENTS WITH HIGH C-PEPTIDE LEVELS

1998 • 45 citations

Requirements for Success in Clinical Islet Transplantation

2005 • 43 citations

Immunotherapy for the Prevention and Treatment of Type 1 Diabetes

2005 • 42 citations

Prevention of Type I Diabetes and Recurrent β-Cell Destruction of Transplanted Islets*

1997 • 42 citations

Islet autoantibodies as potential markers for disease recurrence in clinical islet transplantation

2000 • 40 citations

Evidence of recurrent type I diabetes following HLA-mismatched pancreas transplantation.

2000 • 38 citations

Alloreactivity Against Repeated HLA Mismatches of Sequential Islet Grafts Transplanted in Non-Uremic Type 1 Diabetes Patients

2005 • 30 citations

Feasibility, Safety, and Efficacy of Percutaneous Transhepatic Injection of β-Cell Grafts

2005 • 30 citations

PREVENTION OF AUTOIMMUNE ISLET ALLOGRAFT DESTRUCTION BY ENGRAFTMENT OF DONOR T CELLS1

1997 • 21 citations

The search for the Holy Grail

2007 • 20 citations