Myristoylation of the G alpha i2 polypeptide, a G protein alpha subunit, is required for its signaling and transformation functions.

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

Two G Protein Oncogenes in Human Endocrine Tumors

1990 • 1,038 citations

THE BIOLOGY AND ENZYMOLOGY OF EUKARYOTIC PROTEIN ACYLATION

1988 • 787 citations

Multiple components in an epidermal growth factor-stimulated protein kinase cascade

1991 • 502 citations

The G protein-gated atrial K+ channel is stimulated by three distinct GIα-subunits

1988 • 306 citations

G-protein alpha-subunit expression, myristoylation, and membrane association in COS cells.

1990 • 277 citations

Myristoylated alpha subunits of guanine nucleotide-binding regulatory proteins.

1987 • 276 citations

Lipid modifications of G protein subunits.

1991 • 274 citations

Synthesis in Escherichia coli of GTPase-deficient mutants of Gsα

1989 • 247 citations

MAP kinase is constitutively activated in gip2 and src transformed rat 1a fibroblasts.

1992 • 231 citations

Myristoylation of an inhibitory GTP-binding protein alpha subunit is essential for its membrane attachment.

1990 • 225 citations

Mutant α subunits of Gi2 inhibit cyclic AMP accumulation

1991 • 224 citations

Isolation and characterization of two growth factor-stimulated protein kinases that phosphorylate the epidermal growth factor receptor at threonine 669

1991 • 215 citations

Mutations in the GTP-binding site of GSα alter stimulation of adenylyl cyclase

1989 • 209 citations

Purification and characterization of Go alpha and three types of Gi alpha after expression in Escherichia coli.

1990 • 208 citations

Fatty acylated proteins as components of intracellular signaling pathways

1990 • 202 citations

Identification of a 32K plasma membrane protein that binds to the myristylated amino-terminal sequence of p60v-src

1990 • 162 citations

Construction and Characterization of a Retroviral Vector Demonstrating Efficient Expression of Cloned cDNA Sequences

1988 • 157 citations

The beta-PDGF receptor induces neuronal differentiation of PC12 cells.

1992 • 145 citations

A mutant alpha subunit of Gi2 induces neoplastic transformation of Rat-1 cells.

1991 • 138 citations

Specific and saturable binding of pp60v-src to plasma membranes: Evidence for a myristyl-src receptor

1989 • 137 citations

Analysis of the fibroblast transformation potential of GTPase-deficient gip2 oncogenes.

1992 • 101 citations

N-myristoylation is required for function of the pheromone-responsive G alpha protein of yeast: conditional activation of the pheromone response by a temperature-sensitive N-myristoyl transferase.

1991 • 83 citations

GTPase-deficient G alpha i2 oncogene gip2 inhibits adenylylcyclase and attenuates receptor-stimulated phospholipase A2 activity

1991 • 59 citations

Nonmyristoylated Abl proteins transform a factor-dependent hematopoietic cell line.

1992 • 51 citations

GTP-Binding proteins in brain and neutrophil are tethered to the plasma membrane via their amino termini

1987 • 50 citations

A dominant negative G alpha s mutant is rescued by secondary mutation of the alpha chain amino terminus.

1991 • 48 citations

Conformational changes of adenylate cyclase regulatory proteins mediated by guanine nucleotides.

1981 • 43 citations

Nonmyristoylated Abl Proteins Transform a Factor-Dependent Hematopoietic Cell Line

1992 • 19 citations

Membrane attachment of recombinant G-protein α-subunits in excess of βγ subunits in a eukaryotic expression system

1989 • 19 citations

Analysis of the Fibroblast Transformation Potential of GTPase-Deficient gip2 Oncogenes

1992 • 16 citations

Amino acids 367-376 of the Gs alpha subunit induce membrane association when fused to soluble amino-terminal deleted Gi1 alpha subunit.

1991 • 12 citations