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Insights into the neural basis of response inhibition from cognitive and clinical neuroscience

Data up to Jan 2025

Published2008
Citations901
References244
Clinical Trials (1)

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Abstract

References (244)

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Impulsivity and rapid discounting of delayed hypothetical rewards in cocaine-dependent individuals.

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The neuropsychopharmacology of action inhibition: cross-species translation of the stop-signal and go/no-go tasks

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Abnormal Brain Activation During Inhibition and Error Detection in Medication-Naive Adolescents With ADHD

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Converging Evidence for a Fronto-Basal-Ganglia Network for Inhibitory Control of Action and Cognition: Figure 1.

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Impaired inhibitory control of behavior in chronic cocaine users

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Increased striatal dopamine transporter in adult patients with attention deficit hyperactivity disorder: effects of methylphenidate as measured by single photon emission computed tomography

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Role of the Human Medial Frontal Cortex in Task Switching: A Combined fMRI and TMS Study

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Executive "Brake Failure" following Deactivation of Human Frontal Lobe

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Response Inhibition and Response Selection: Two Sides of the Same Coin

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Impulsivity and rapid discounting of delayed hypothetical rewards in cocaine-dependent individuals.

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Prefrontal cognitive processes: Working memory and inhibition in the antisaccade task.

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Common and unique components of response inhibition revealed by fMRI

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Epidemiology of attention-deficit/hyperactivity disorder across the lifespan

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Infrequent Events Transiently Activate Human Prefrontal and Parietal Cortex as Measured by Functional MRI

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Dissociable Contributions of Prefrontal and Parietal Cortices to Response Selection

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Prefrontal Regions Orchestrate Suppression of Emotional Memories via a Two-Phase Process

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Quantitative morphology of the caudate nucleus in attention deficit hyperactivity disorder

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The role of the inferior frontal junction area in cognitive control

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Neurocognitive endophenotypes of obsessive-compulsive disorder

2007 • 429 citations

The functional neuroanatomical correlates of response variability: evidence from a response inhibition task

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The VNTR polymorphism of the human dopamine transporter (DAT1) gene affects gene expression

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Higher cortical functions in man

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Temporary interference in human lateral premotor cortex suggests dominance for the selection of movements. A study using transcranial magnetic stimulation

1998 • 412 citations

The role of the pre-supplementary motor area in the control of action

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An fMRI Stroop Task Study of Ventromedial Prefrontal Cortical Function in Pathological Gamblers

2003 • 398 citations

Impaired Cognitive Flexibility and Motor Inhibition in Unaffected First-Degree Relatives of Patients With Obsessive-Compulsive Disorder

2007 • 391 citations

Methylphenidate improves response inhibition in adults with attention-deficit/hyperactivity disorder

2003 • 388 citations

Stop-Signal Reaction-Time Task Performance: Role of Prefrontal Cortex and Subthalamic Nucleus

2007 • 387 citations

Effects of Focal Frontal Lesions on Response Inhibition

2006 • 377 citations

Similar Effects of the Selective Noradrenaline Reuptake Inhibitor Atomoxetine on Three Distinct Forms of Impulsivity in the Rat

2007 • 358 citations

Reflection Impulsivity in Current and Former Substance Users

2006 • 354 citations

Executive “Brake Failure” following Deactivation of Human Frontal Lobe

2006 • 342 citations

Differences in the functional neuroanatomy of inhibitory control across the adult life span.

2002 • 339 citations

Intracortical Inhibition During Volitional Inhibition of Prepared Action

2006 • 337 citations

Attentional bias predicts outcome in smoking cessation.

2003 • 335 citations

Prospective, Longitudinal Study of Tic, Obsessive-Compulsive, and Attention-Deficit/Hyperactivity Disorders in an Epidemiological Sample

2001 • 330 citations

Larger deficits in brain networks for response inhibition than for visual selective attention in attention deficit hyperactivity disorder (ADHD)

2004 • 326 citations

Functional deficits in basal ganglia of children with attention-deficit/hyperactivity disorder shown with functional magnetic resonance imaging relaxometry

2000 • 320 citations

Cognitive control mechanisms, emotion and memory: A neural perspective with implications for psychopathology

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Cognitive control in the posterior frontolateral cortex: evidence from common activations in task coordination, interference control, and working memory

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The variable number of tandem repeats element in DAT1 regulates in vitro dopamine transporter density

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fMRI evidence that the neural basis of response inhibition is task-dependent

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Role for Subthalamic Nucleus Neurons in Switching from Automatic to Controlled Eye Movement

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Parental investment theory and gender differences in the evolution of inhibition mechanisms.

1996 • 299 citations

Impaired response inhibition in obsessive compulsive disorder

2006 • 297 citations

Differences in the functional neuroanatomy of inhibitory control across the adult life span.

2002 • 292 citations

Inhibitory Control is Slowed in Patients with Right Superior Medial Frontal Damage

2006 • 291 citations

A topography of executive functions and their interactions revealed by functional magnetic resonance imaging

2004 • 288 citations

Activation of Right Inferior Frontal Gyrus during Response Inhibition across Response Modalities

2007 • 286 citations

Attention deficit hyperactivity disorder: binding of [99mTc]TRODAT-1 to the dopamine transporter before and after methylphenidate treatment

2000 • 285 citations

Common Neural Substrates for Inhibition of Spoken and Manual Responses

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Individual differences in the functional neuroanatomy of inhibitory control

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Attention deficit/hyperactivity disorder children with a 7-repeat allele of the dopamine receptor D4 gene have extreme behavior but normal performance on critical neuropsychological tests of attention

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Functional anatomy of GO/NO-GO discrimination and response selection – a PET study in man

1996 • 269 citations

Event-Related fMRI Evidence of Frontotemporal Involvement in Aberrant Response Inhibition and Task Switching in Attention-Deficit/Hyperactivity Disorder

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Stimulation of the Subthalamic Region Facilitates the Selection and Inhibition of Motor Responses in Parkinson's Disease

2006 • 263 citations

Basal Ganglia Volumes in Children With Attention-Deficit Hyperactivity Disorder

1996 • 263 citations

Response Inhibition in Adolescents Diagnosed With Attention Deficit Hyperactivity Disorder During Childhood: An Event-Related fMRI Study

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"Loss of control" in alcoholism and drug addiction: A neuroscientific interpretation.

2000 • 252 citations

Comorbidity of Juvenile Obsessive-Compulsive Disorder with Disruptive Behavior Disorders

1996 • 251 citations

Three decision‐making tasks in cocaine‐dependent patients: do they measure the same construct?

2001 • 250 citations

Inhibitory Control in Rats Performing a Stop-Signal Reaction-Time Task: Effects of Lesions of the Medial Striatum and d-Amphetamine.

2003 • 249 citations

Fast and slow parietal pathways mediate spatial attention

2004 • 249 citations

"Loss of control" in alcoholism and drug addiction: A neuroscientific interpretation.

2000 • 249 citations

Dopamine D4 Gene 7-Repeat Allele and Attention Deficit Hyperactivity Disorder

1999 • 243 citations

Brain-derived neurotrophic factor mediates estradiol-induced dendritic spine formation in hippocampal neurons

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Role for cells in the presupplementary motor area in updating motor plans.

1996 • 241 citations

Brain dopamine transporter levels in treatment and drug naïve adults with ADHD

2006 • 240 citations

Dissociable Mechanisms of Cognitive Control in Prefrontal and Premotor Cortex

2007 • 240 citations

Do Executive Deficits and Delay Aversion Make Independent Contributions to Preschool Attention-Deficit/Hyperactivity Disorder Symptoms?

2003 • 233 citations

Analysis of DRD4 and DAT polymorphisms and behavioral inhibition in healthy adults: Implications for impulsivity

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Neural Activation During Response Competition

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Increased Dopamine Receptor Sensitivity After Estrogen Treatment Using the Rat Rotation Model

1980 • 222 citations

Prefrontal‐subcortical dissociations underlying inhibitory control revealed by event‐related fMRI

2004 • 222 citations

Differential effects of DRD4 and DAT1 genotype on fronto-striatal gray matter volumes in a sample of subjects with attention deficit hyperactivity disorder, their unaffected siblings, and controls

2005 • 220 citations

Methylphenidate and cognitive flexibility: Dissociated dose effects in hyperactive children

1995 • 220 citations

Association of the dopamine transporter (DAT1) 10/10-repeat genotype with ADHD symptoms and response inhibition in a general population sample

2005 • 217 citations

Orbitofrontal cortex activity related to emotional processing changes across the menstrual cycle

2005 • 217 citations

Neuroimaging of Inhibitory Control Areas in Children With Attention Deficit Hyperactivity Disorder Who Were Treatment Naive or in Long-Term Treatment

2006 • 216 citations

A consistent attentional bias for drug-related material in active cocaine users across word and picture versions of the emotional Stroop task

2005 • 213 citations

Attention to Action: Specific Modulation of Corticocortical Interactions in Humans

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Premotor cortex and the conditions for movement in monkeys (Macaca fascicularis)

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Acute Stimulatory Effect of Estradiol on Striatal Dopamine Synthesis

1995 • 197 citations

Activation in Ventral Prefrontal Cortex is Sensitive to Genetic Vulnerability for Attention-Deficit Hyperactivity Disorder

2006 • 197 citations

Cognitive Control Mechanisms Revealed by ERP and fMRI: Evidence from Repeated Task-Switching

2003 • 196 citations

Inhibition of action, thought, and emotion: A selective neurobiological review

2007 • 194 citations

Gender differences in the neural correlates of response inhibition during a stop signal task

2006 • 190 citations

Common and Differential Ventrolateral Prefrontal Activity during Inhibition of Hand and Eye Movements

2007 • 187 citations

Control of prepotent responses by the superior medial frontal cortex

2008 • 186 citations

Dopamine transporter density in the basal ganglia assessed with [123I]IPT SPET in children with attention deficit hyperactivity disorder

2003 • 185 citations

The dopamine transporter and neuroimaging in attention deficit hyperactivity disorder

2003 • 185 citations

Association of the Dopamine D4 Receptor Gene 7-Repeat Allele With Neuropsychological Test Performance of Children With ADHD

2004 • 184 citations

Deficient Response Inhibition as a Cognitive Endophenotype of ADHD

2003 • 182 citations

Inhibition of ongoing responses following frontal, nonfrontal, and basal ganglia lesions.

2003 • 176 citations

Differential effects of modafinil and methylphenidate on stop-signal reaction time task performance in the rat, and interactions with the dopamine receptor antagonist cis-flupenthixol

2007 • 176 citations

Stop signal response inhibition is not modulated by tryptophan depletion or the serotonin transporter polymorphism in healthy volunteers: implications for the 5-HT theory of impulsivity

2005 • 175 citations

The influence of estrogen on nigrostriatal dopamine activity

1986 • 174 citations

Event-Related Functional Magnetic Resonance Imaging of Response Inhibition in Obsessive-Compulsive Disorder

2007 • 173 citations

Tryptophan depletion reduces right inferior prefrontal activation during response inhibition in fast, event-related fMRI

2005 • 171 citations

Association of cortical disinhibition with tic, ADHD, and OCD severity in Tourette syndrome

2004 • 171 citations

The effect of methylphenidate on three forms of response inhibition in boys with AD/HD.

2003 • 169 citations

Effects of estradiol and progesterone administration on human serotonin 2A receptor binding: a PET study

2000 • 167 citations

Addiction changes orbitofrontal gyrus function: involvement in response inhibition

2001 • 163 citations

The homozygosity for 10-repeat allele at dopamine transporter gene and dopamine transporter density in Korean children with attention deficit hyperactivity disorder: relating to treatment response to methylphenidate

2004 • 161 citations

Cocaine exposure causes long-term increases in impulsive choice.

2007 • 159 citations

Working memory and executive function: The influence of content and load on the control of attention

2005 • 159 citations

Cognitive motor control in human pre-supplementary motor area studied by subdural recording of discrimination/selection-related potentials

1999 • 158 citations

Risky decision making and the anterior cingulate cortex in abstinent drug abusers and nonusers

2005 • 158 citations

Effects of estrogen variation on neural correlates of emotional response inhibition

2006 • 158 citations

The interaction between stop signal inhibition and distractor interference in the flanker and Stroop task

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Enhancing the Sensitivity of a Sustained Attention Task to Frontal Damage: Convergent Clinical and Functional Imaging Evidence

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Saccadic eye movement and working memory deficits following damage to human prefrontal cortex

1998 • 154 citations

II. Localization and characterization of dopamine D4 binding sites in rat and human brain by use of the novel, D4 receptor-selective ligand [3H]NGD 94-1.

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Functional Magnetic Resonance Imaging Evidence for Abnormalities in Response Selection in Attention Deficit Hyperactivity Disorder: Differences in Activation Associated with Response Inhibition but Not Habitual Motor Response

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Sex differences in child-onset, life-course-persistent conduct disorder. A review of biological influences

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Acute effects of cocaine on the neurobiology of cognitive control

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Functional brain correlates of response time variability in children

2007 • 140 citations

Acute effects of oral cocaine on inhibitory control of behavior in humans

2002 • 139 citations

Deficient Inhibition as a Marker for Familial ADHD

2001 • 137 citations

Human Prefrontal Cortex Is Not Specific for Working Memory: A Functional MRI Study

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Neural Evidence for Representation-Specific Response Selection

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Tryptophan hydroxylase 2 (TPH2) gene variants associated with ADHD

2005 • 134 citations

Cerebral Integration of Ocular Movements

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Working Memory and the Suppression of Reflexive Saccades

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Latent Class Analysis of Gilles de la Tourette Syndrome Using Comorbidities: Clinical and Genetic Implications

2008 • 131 citations

Predicting Success: Patterns of Cortical Activation and Deactivation Prior to Response Inhibition

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Impaired Inhibitory Control in Recreational Cocaine Users

2007 • 128 citations

Estrogen Replacement Attenuates Effects of Scopolamine and Lorazepam on Memory Acquisition and Retention

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Modality-Specific Control of Strategic Spatial Attention in Parietal Cortex

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Comparative pharmacological and functional analysis of the human dopamine D4.2 and D4.10 receptor variants

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Genetics of human prefrontal function

2003 • 118 citations

Material-dependent and material-independent selection processes in the frontal and parietal lobes: an event-related fMRI investigation of response competition

2003 • 118 citations

Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in children and adolescents with obsessive–compulsive disorder

2005 • 116 citations

Inefficient response inhibition in individuals with mild cognitive impairment

2006 • 113 citations

Dopamine Transporter Genotype Conveys Familial Risk of Attention-Deficit/Hyperactivity Disorder Through Striatal Activation

2008 • 110 citations

Stop and Go: The Neural Basis of Selective Movement Prevention

2008 • 109 citations

An experimental investigation of Luria's theory on the effects of frontal lobe lesions in man

1975 • 109 citations

Impaired Cognitive Flexibility and Motor Inhibition in Unaffected First-Degree Relatives of Patients With Obsessive-Compulsive Disorder

2007 • 104 citations

The role of the ventrolateral frontal cortex in inhibitory oculomotor control

2007 • 98 citations

DRD4gene variants and sustained attention in attention deficit hyperactivity disorder (ADHD): Effects of associated alleles at the VNTR and −521 SNP

2005 • 96 citations

Relationship between VNTR polymorphisms of the human dopamine transporter gene and expression in post‐mortem midbrain tissue

2007 • 95 citations

Magnetic stimulation of the dorsal premotor cortex modulates the Simon effect

1999 • 95 citations

Inhibition of Motor Responses in Siblings Concordant and Discordant for Attention Deficit Hyperactivity Disorder

2005 • 87 citations

Reduced response-inhibition in obsessive–compulsive disorder measured with topographic evoked potential mapping

2003 • 86 citations

Transcranial Magnetic Stimulation-Evoked Cortical Inhibition: A Consistent Marker of Attention-Deficit/Hyperactivity Disorder Scores in Tourette Syndrome

2005 • 86 citations

Familial Vulnerability to ADHD Affects Activity in the Cerebellum in Addition to the Prefrontal Systems

2008 • 86 citations

The Role of a Right Fronto-Parietal Network in Cognitive Control

2006 • 85 citations

THE EFFECTS OF ALCOHOL CUE EXPOSURE ON NON-DEPENDENT DRINKERS' ATTENTIONAL BIAS FOR ALCOHOL-RELATED STIMULI

2003 • 84 citations

Dopamine transporter genotype influences the physiological response to medication in ADHD

2006 • 83 citations

Estimation of Prevalence of DSM-IV and Latent Class-Defined ADHD Subtypes in a Population-Based Sample of Child and Adolescent Twins

2005 • 81 citations

The effect of acute tryptophan depletion on the BOLD response during performance monitoring and response inhibition in healthy male volunteers

2006 • 81 citations

Beyond common resources: the cortical basis for resolving task interference

2004 • 74 citations

Neurodisruption of selective attention: insights and implications

2005 • 71 citations

Changes in sensory inattention, directional motor neglect and “release” of the fixation reflex following a unilateral frontal lesion: A case report

1988 • 67 citations

Absence of the 7‐repeat variant of the DRD4 VNTR is associated with drifting sustained attention in children with ADHD but not in controls

2008 • 67 citations

Possible association between response inhibition and a variant in the brain-expressed tryptophan hydroxylase-2 gene

2006 • 63 citations

Response selection deficits in frontal excisions

1995 • 55 citations

What stimulation of the supplementary motor area in humans tells about its functional organization.

1996 • 55 citations

Flexible cognitive control: Effects of individual differences and brief practice on a complex cognitive task

2006 • 54 citations

Estrogen regulates galanin but not tyrosine hydroxylase gene expression in the rat locus ceruleus

1997 • 46 citations

Familial Clustering of Executive Functioning in Affected Sibling Pair Families With ADHD

2005 • 42 citations

Human intraparietal sulcus (IPS) and competition between exogenous and endogenous saccade plans

2007 • 42 citations

Cocaine improves inhibitory control in a human model of response conflict.

2005 • 32 citations

The ventral premotor cortex (VPM) and resistance to interference.

2006 • 29 citations

5-HT, prefrontal function and aging: fMRI of inhibition and acute tryptophan depletion

2007 • 28 citations

Rapid stimulation of striatal dopamine synthesis by estradiol

1996 • 28 citations

Neuroimaging and Human Genetics

2005 • 27 citations

Exploring the contributions of premotor and parietal cortex to spatial compatibility using image-guided TMS

2004 • 24 citations

A rapid presentation event-related functional magnetic resonance imaging study of response inhibition in macaque monkeys

2004 • 22 citations

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