Purification, toxicity, and antiendotoxin activity of polymyxin B nonapeptide

Biological Defense Mechanisms. THE PRODUCTION BY LEUKOCYTES OF SUPEROXIDE, A POTENTIAL BACTERICIDAL AGENT

1973 • 2,955 citations

Treatment of Gram-Negative Bacteremia and Shock with Human Antiserum to a MutantEscherichia coli

1982 • 1,062 citations

Binding of polymyxin B to the lipid A portion of bacterial lipopolysaccharides

1976 • 818 citations

The microestimation of succinate and the extinction coefficient of cytochrome c

1959 • 751 citations

The role of superoxide anion generation in phagocytic bactericidal activity. Studies with normal and chronic granulomatous disease leukocytes.

1975 • 705 citations

An Evaluation of Ten Pairwise Multiple Comparison Procedures by Monte Carlo Methods

1973 • 654 citations

Priming of neutrophils for enhanced release of oxygen metabolites by bacterial lipopolysaccharide. Evidence for increased activity of the superoxide-producing enzyme.

1984 • 612 citations

Gram-negative bacteremia

1980 • 600 citations

Beyond ANOVA, basics of applied statistics

1986 • 585 citations

Bacteremia at Boston City Hospital: Occurrence and Mortality during 12 Selected Years (1935-1972), with Special Reference to Hospital-Acquired Cases

1975 • 511 citations

Adverse Effects of Sodium Colistimethate

1970 • 428 citations

Analysis of 1,186 Episodes of Gram-Negative Bacteremia in Non-University Hospitals: The Effects of Antimicrobial Therapy

1983 • 369 citations

Polycations as outer membrane-disorganizing agents

1983 • 254 citations

Kinetics of Endotoxin Release During Antibiotic Therapy For Experimental Gram-Negative Bacterial Sepsis

1984 • 235 citations

Interaction of polycationic antibiotics with Pseudomonas aeruginosa lipopolysaccharide and lipid A studied by using dansyl-polymyxin

1986 • 232 citations

Sensitization of Gram-negative bacteria to antibiotics and complement by a nontoxic oligopeptide

1983 • 227 citations

Polymyxin B is a more selective inhibitor for phospholipid-sensitive Ca2+-dependent protein kinase than for calmodulin-sensitive Ca2+-dependent protein kinase

1982 • 212 citations

Polycations sensitize enteric bacteria to antibiotics

1983 • 209 citations

Role of Antibiotic Class in the Rate of Liberation of Endotoxin During Therapy for Experimental Gram-Negative Bacterial Sepsis

1985 • 188 citations

Gram-negative rod bacteremia

1965 • 184 citations

Prevention by polymyxin B of endotoxin lethality in mice

1967 • 183 citations

The inhibitory effect of polymyxin B on endotoxin-induced endogenous pyrogen production

1982 • 179 citations

Serial Quantitation of Endotoxemia and Bacteremia During Therapy for Gram-Negative Bacterial Sepsis

1988 • 178 citations

The Changing Pattern of Life-Threatening Microbial Disease

1959 • 155 citations

This is Medical Progress?

1974 • 134 citations

Susceptibility of gram-negative bacteria to polymyxin B nonapeptide

1984 • 106 citations

Gram-Negative-Rod Bacteremia

1974 • 104 citations

Binding of polymyxin B nonapeptide to gram-negative bacteria

1985 • 88 citations

Endotoxin-induced intravascular coagulation: prevention with polymyxin B sulfate.

1971 • 78 citations

Binding and neutralization of bacterial lipopolysaccharide by colistin nonapeptide

1985 • 67 citations

Inhibition of endotoxin-induced priming of human neutrophils by lipid X and 3-Aza-lipid X.

1987 • 67 citations

Effect of Polymyxin B Sulfate on Endotoxin Activity in a Gram-Negative Septicemia Model

1979 • 66 citations

Polymyxin B sulfate modification of bacterial endotoxin: effects on the development of endotoxin shock in dogs

1979 • 58 citations

An outer membrane-disorganizing peptide PMBN sensitizes E. coli strains to serum bactericidal action.

1984 • 52 citations

Neutralization of the hemodynamic effects of endotoxin by polymyxin B.

1974 • 51 citations

Polymyxin B Moderates Acidosis and Hypotension in Established, Experimental Gram-Negative Septicemia

1987 • 50 citations

In vitro cytotoxicity and antibiotic activity of polymyxin B nonapeptide

1986 • 50 citations

Polymyxin B nonapeptide complexes with lipopolysaccharide

1983 • 49 citations

STUDIES ON TUBERCULIN FEVER

1965 • 48 citations

Inhibition of the Biologic Effects of Endotoxin on Neutrophils by Polymyxin B Sulfate

1977 • 47 citations

Polymyxin B causes coordinate inhibition of phorbol ester-induced C-kinase activity and proliferation of B lymphocytes

1985 • 42 citations

Dynamics of binding and release of the polymyxin antibiotics by tissues.

1973 • 39 citations

Polymyxin B inhibits phorbol 12‐myristate 13‐acetate, but not chemotactic factor, induced effects in rabbit neutrophils

1985 • 38 citations

Chemical Synthesis, Isolation and Characterization of α-N-Fattyacyl Colistin Nonapeptide with Special Reference to the Correlation between Antimicrobial Activity and Carbon Number of Fattyacyl Moiety

1974 • 37 citations

Comparison Between the Polymyxins and Gentamicin in Preventing Endotoxin-Induced Intravascular Coagulation and Leukopenia

1971 • 37 citations

POLYMYXIN B SULPHATE PROTECTS CATS AGAINST THE HAEMODYNAMIC AND METABOLIC EFFECTS OF E. coli ENDOTOXIN

1981 • 35 citations

TOXICITY OF POLYMYXIN B

1953 • 32 citations

Enzymatic Degradation of Colistin Isolation and Identification ofα-N-Acylα,γ-Diaminobutyric Acid and Colistin Nonapeptide

1973 • 31 citations

コリスチンの酵素分解 コリスチンノナペプチドおよびα-N-アシル-α,γ-ジアミノ酪酸の分離同定

1973 • 28 citations

Polymyxin B Inactivation of Lipopolysaccharide in Vaccines of Gram-Negative Bacteria

1981 • 26 citations

Effect of Immune Serum or Polymyxin B on Escherichia coli -Induced Inflammation and Vascular Injury

1982 • 19 citations

The relative nephrotoxicities of polymyxin B sulfate, sodium sulfomethyl-polymyxin B, sodium sulfomethyl-colistin (colymycin), and neomycin sulfate.

1969 • 16 citations

Deleted Work

1955 • 0 citations