A Structure-Based Analysis of the Inhibition of Class A .beta.-Lactamases by Sulbactam

Theoretical studies of enzymic reactions: Dielectric, electrostatic and steric stabilization of the carbonium ion in the reaction of lysozyme

1976 • 4,264 citations

The determination of enzyme inhibitor constants

1953 • 4,050 citations

Atomic charges derived from semiempirical methods

1990 • 3,157 citations

More extended-spectrum beta-lactamases

1991 • 740 citations

Molecular structure of the acyl-enzyme intermediate in β-lactam hydrolysis at 1.7 Å resolution

1992 • 515 citations

CP-45,899, a Beta-Lactamase Inhibitor That Extends the Antibacterial Spectrum of Beta-Lactams: Initial Bacteriological Characterization

1978 • 399 citations

Crystal structure of Escherichia coli TEM1 β‐lactamase at 1.8 Å resolution

1993 • 349 citations

Bacterial Resistance to β-Lactam Antibiotics: Crystal Structure of β-Lactamase from Staphylococcus aureus PC1 at 2.5 Å Resolution

1987 • 349 citations

Refined crystal structure of β-lactamase from Citrobacter freundiiindicates a mechanism for β-lactam hydrolysis

1990 • 299 citations

Kinetic interactions of tazobactam with beta-lactamases from all major structural classes

1993 • 273 citations

Penicillin resistance: the chemistry of .beta.-lactamase inhibition

1985 • 223 citations

Refined crystal structure of β-lactamase from Staphylococcus aureus PC1 at 2.0 Å resolution

1991 • 217 citations

Evolution of an enzyme activity: crystallographic structure at 2-A resolution of cephalosporinase from the ampC gene of Enterobacter cloacae P99 and comparison with a class A penicillinase.

1993 • 194 citations

The mechanisms of reactions of .beta.-lactam antibiotics

1984 • 189 citations

β‐Lactamase of Bacillus licheniformis 749/C at 2 Å resolution

1990 • 175 citations

Mechanism of acyl transfer by the class A serine β-lactamase of Streptomyces albus G

1991 • 172 citations

The crystal structure of the β-lactamase of Streptomyces albus G at 0.3 nm resolution

1987 • 149 citations

β-Lactamase of Bacillus licheniformis 749/C

1991 • 141 citations

Inactivation of class A .beta.-lactamases by clavulanic acid: the role of arginine-244 in a proposed nonconcerted sequence of events

1993 • 135 citations

Clinical isolates of Escherichia coli producing TRI β-lactamases: novel TEM-enzymes conferring resistance to β-lactamase inhibitors

1992 • 119 citations

-Lactamases of Gram-Negative Bacteria: New Challenges for New Drugs

1992 • 117 citations

Elucidation of the role of arginine-224 in the turnover processes of class A .beta.-lactamases

1992 • 116 citations

Inactivation of the RTEM .beta.-lactamase from Escherichia coli. Interaction of penam sulfones with the enzyme

1981 • 110 citations

Penicillanic acid sulfone: an unexpected isotope effect in the interaction of 6.alpha.- and 6.beta.-monodeuterio and of 6,6-dideuterio derivatives with RTEM .beta.-lactamase from Escherichia coli. Crystal structure of penicillanic acid sulfone

1981 • 107 citations

Analysis of Enzyme Structure and Activity by Protein Engineering

1984 • 97 citations

Site-directed mutagenesis at the active site of Escherichia coli TEM-1 beta-lactamase. Suicide inhibitor-resistant mutants reveal the role of arginine 244 and methionine 69 in catalysis.

1992 • 96 citations

The role of lysine-234 in .beta.-lactamase catalysis probed by site-directed mutagenesis

1990 • 87 citations

Hydrogen bonding in enzymatic catalysis analysed by protein engineering

1985 • 78 citations

Vinylogous imides. II. Ultraviolet spectra and the application of Woodward's rules

1970 • 69 citations

Inactivation of radiolabeled RTEM .beta.-lactamase from Escherichia coli by clavulanic acid and 9-deoxyclavulanic acid

1981 • 67 citations

Elimination of a good leaving group from the 3'-position of a cephalosporin need not be concerted with .beta.-lactam ring opening: TEM-2 .beta.-lactamase-catalyzed hydrolysis of pyridine-2-azo-4'-(N',N'-dimethylaniline) cephalosporin (PADAC) and of cephaloridine

1984 • 66 citations

Augmentin (amoxycillin and clavulanic acid) therapy in complicated infections due to β-lactamase producing bacteria

1981 • 61 citations

Penicillanic acid sulfone: nature of irreversible inactivation of the RTEM .beta.-lactamase from Escherichia coli

1984 • 56 citations

Efficient preparation of 6,6-dihalopenicillanic acids. Synthesis of penicillanic acid S,S-dioxide (sulbactam)

1982 • 56 citations

Mechanism of .beta.-lactam ring opening in cephalosporins

1984 • 55 citations

Replacement of lysine 234 affects transition state stabilization in the active site of beta-lactamase TEM1.

1991 • 48 citations

Site-saturation mutagenesis and three-dimensional modelling of ROB-1 define a substrate binding role of Ser 130 in class A β-lactamases

1992 • 47 citations

Engineering a novel β-Iactamase by a single point mutation

1990 • 41 citations

Use of binding energy in catalysis: Optimization of rate in a multistep reaction

1993 • 35 citations

Critical hydrogen bonding by serine 235 for cephalosporinase activity of TEM-1 beta-lactamase

1993 • 33 citations

Halogenation of acetone. A method for determining pKas of ketones in aqueous solution, with an examination of the thermodynamics and kinetics of alkaline halogenation and a discussion of the best value for the rate constant for a diffusion-controlled reaction. Energetic requirements for a diffusion-controlled reaction involving heavy-atom bond formation

1984 • 31 citations

Base-catalyzed halogenation of acetone

1982 • 31 citations

Streptomyces albus G serine β-lactamase. Probing of the catalytic mechanism via molecular modelling of mutant enzymes

1992 • 27 citations

Determination of the configuration of some penicillin S-oxides by 13C nuclear magnetic resonance spectroscopy

1976 • 27 citations

Interactions between active-site-serine β-lactamases and mechanism-based inactivators: a kinetic study and an overview

1993 • 20 citations

Ammonolysis of cephamycins: carbon-13 NMR characterization of the intermediates from .beta.-lactam ring cleavage prior to loss of the 3'-group

1985 • 20 citations

Equilibrium and kinetic studies of some reactions of 1-anthraquinonesulfenic acid and its methyl ester

1989 • 14 citations

β-Lactamase Inhibition: Therapeutic Implications in Infectious Diseases—an Overview

1991 • 14 citations

The chemistry of penicillanic acids. Part I. 6,6-Dibromo- and 6,6-di-iodo-derivatives

1969 • 13 citations

Mechanism of beta-lactamase inhibition: Differences between sulbactam and other inhibitors

1989 • 9 citations

Penicillin and cephalosporin sulphoximines

1979 • 6 citations

Some observations regarding β-lactam-cleavage reactions of penicillanate 1,1-dioxides and related compounds

1984 • 5 citations

Conformational changes in the inactivation of .beta.-lactamase by penicillin sulfones

1989 • 3 citations