Elucidation of the role of arginine-224 in the turnover processes of class A .beta.-lactamases

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

The determination of enzyme inhibitor constants

1953 • 4,050 citations

Hydrogen bonding in globular proteins

1984 • 1,760 citations

Hydrogen bonding and biological specificity analysed by protein engineering

1985 • 1,050 citations

Bacterial Resistance to β-Lactam Antibiotics: Crystal Structure of β-Lactamase from Staphylococcus aureus PC1 at 2.5 Å Resolution

1987 • 349 citations

Tinkering with Enzymes: What Are We Learning?

1987 • 304 citations

.beta.-Lactamase proceeds via an acyl-enzyme intermediate. Interaction of the Escherichia coli RTEM enzyme with cefoxitin

1980 • 222 citations

β‐Lactamase of Bacillus licheniformis 749/C at 2 Å resolution

1990 • 175 citations

β-Lactamase of Bacillus licheniformis 749/C

1991 • 141 citations

Role of the conserved amino acids of the ‘SDN’ loop (Ser130, Asp131 and Asn132) in a class A β-lactamase studied by site-directed mutagenesis

1990 • 107 citations

Analysis of Enzyme Structure and Activity by Protein Engineering

1984 • 97 citations

The role of lysine-234 in .beta.-lactamase catalysis probed by site-directed mutagenesis

1990 • 87 citations

A METHOD FOR IMPROVED LYSIS OF SOME GRAM-NEGATIVE BACTERIA

1980 • 63 citations

Relationships between enzymatic catalysis and active site structure revealed by applications of site-directed mutagenesis

1987 • 54 citations

Replacement of lysine 234 affects transition state stabilization in the active site of beta-lactamase TEM1.

1991 • 48 citations

Arginine 220 is a critical residue for the catalytic mechanism of the Streptomyces albus G β-lactamase

1991 • 33 citations

The mutation Lys234His yields a class A β-lactamase with a novel pH-dependence

1991 • 32 citations

Cryoenzymology of staphylococcal .beta.-lactamase: trapping a serine-70-linked acyl-enzyme

1990 • 31 citations

A graphical method for extracting rate constants from some enzyme-catalyzed reactions not monitored to completion

1978 • 22 citations

Activation of factor V during intrinsic and extrinsic coagulation. Inhibition by heparin, hirudin and <scp>d</scp>-Phe-Pro-Arg-Ch2Cl

1990 • 19 citations