Regulation of porcine brain alpha 2-adrenergic receptors by Na+,H+ and inhibitors of Na+/H+ exchange.

Pyrazine Diuretics. II. N-Amidino-3-amino-5-substituted 6-Halopyrazinecarboxamides

1967 • 323 citations

Structure-activity relationships of amiloride and certain of its analogues in relation to the blockade of the Na+/H+ exchange system.

1984 • 204 citations

Amiloride inhibits phorbol ester-stimulated Na+/H+ exchange and protein kinase C. An amiloride analog selectively inhibits Na+/H+ exchange.

1985 • 203 citations

Interaction of external H+ with the Na+-H+ exchanger in renal microvillus membrane vesicles.

1983 • 200 citations

Evidence that Na+/H+ exchange regulates receptor-mediated phospholipase A2 activation in human platelets.

1986 • 196 citations

Inhibition of adenylate cyclase by hormones and neurotransmitters

1979 • 187 citations

Ethylisopropyl-amiloride: A new and highly potent derivative of amiloride for the inhibition of the Na+H+ exchange system in various cell types

1983 • 168 citations

Agonist-specific effects of monovalent and divalent cations on adenylate cyclase-coupled alpha adrenergic receptors in rabbit platelets.

1978 • 162 citations

Inhibitors of Na+/H+ exchange block epinephrine- and ADP-induced stimulation of human platelet phospholipase C by blockade of arachidonic acid release at a prior step.

1986 • 158 citations

The regulation of cytoplasmic pH in human fibroblasts.

1984 • 157 citations

Amiloride directly inhibits growth factor receptor tyrosine kinase activity.

1985 • 155 citations

Inhibitors of Na+/H+ exchange block stimulus-provoked arachidonic acid release in human platelets. Selective effects on platelet activation by epinephrine, ADP, and lower concentrations of thrombin.

1985 • 144 citations

The growth factor-activatable Na+/H+ exchange system: a genetic approach

1985 • 119 citations

Influence of sodium on the alpha 2-adrenergic receptor system of human platelets. Role for intraplatelet sodium in receptor binding.

1983 • 112 citations

Sodium ion modulates agonist and antagonist interactions with the human platelet alpha 2-adrenergic receptor in membrane and solubilized preparations.

1982 • 101 citations

The influence of Na+ on the alpha 2-adrenergic receptor system of human platelets. A method for removal of extraplatelet Na+. Effect of Na+ removal on aggregation, secretion, and cAMP accumulation.

1983 • 74 citations

Alpha 2-adrenergic receptors accelerate Na+/H+ exchange in neuroblastoma X glioma cells.

1987 • 66 citations

Estimation of the number and turnover rate of Na+/H+ exchangers in lymphocytes. Effect of phorbol ester and osmotic shrinking.

1987 • 65 citations

[3H]Ethylpropylamiloride, a ligand to analyze the properties of the Na+/H+ exchange system in the membranes of normal and hypertrophied kidneys.

1985 • 51 citations

Inhibition of synaptosomal membrane Na+-Ca2+ exchange transport by amiloride and amiloride analogues.

1985 • 47 citations

Purification of the alpha 2-adrenergic receptor from porcine brain using a yohimbine-agarose affinity matrix.

1987 • 34 citations

Photoaffinity labeling of the porcine brain alpha 2-adrenergic receptor using a radioiodinated arylazide derivative of rauwolscine: identification of the hormone-binding subunit.

1986 • 14 citations