Phagocytosis of bacteria and phospholipid degradation

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

ARACHIDONIC ACID METABOLISM

1986 • 1,802 citations

The Enzymes of Biological Membranes

1985 • 1,362 citations

Intracellular phospholipases A

1980 • 989 citations

Molecular basis of bacterial outer membrane permeability.

1985 • 904 citations

Molecular architecture and functioning of the outer membrane of Escherichia coli and other gram-negative bacteria

1983 • 782 citations

Labeling of proteins by reductive methylation using sodium cyanoborohydride.

1979 • 776 citations

The Role of Protein Kinase C in Transmembrane Signalling

1986 • 557 citations

The Membrane Attack Complex of Complement

1986 • 510 citations

Structure and function of phospholiphase A2

1981 • 478 citations

Purification and characterization of a potent bactericidal and membrane active protein from the granules of human polymorphonuclear leukocytes.

1978 • 466 citations

Phosphoglyceride Metabolism

1974 • 416 citations

Amino acid sequence of phospholipase A2-alpha from the venom of Crotalus adamanteus. A new classification of phospholipases A2 based upon structural determinants.

1977 • 406 citations

Hormone-stimulated polyphosphoinositide breakdown in rat liver plasma membranes. Roles of guanine nucleotides and calcium.

1986 • 378 citations

Damage to Schistosomula of Schistosoma Mansoni Induced Directly by Eosinophil Major Basic Protein

1979 • 368 citations

Phospholipase A2 activity specific for phosphatidic acid. A possible mechanism for the production of arachidonic acid in platelets.

1981 • 368 citations

Is phosphatidic acid a calcium ionophore under neurohumoral control?

1980 • 331 citations

Receptor-Coupled Activation of Phosphoinositide-Specific Phospholipase C by an N Protein

1986 • 324 citations

Interaction of divalent cations and polymyxin B with lipopolysaccharide

1979 • 322 citations

Identification of neutral active phospholipase C which hydrolyzes choline glycerophospholipids and plasmalogen selective phospholipase A2 in canine myocardium.

1985 • 315 citations

Release and metabolism of arachidonic acid in human neutrophils.

1981 • 281 citations

Detoxification of Bacterial Lipopolysaccharides (Endotoxins) by a Human Neutrophil Enzyme

1986 • 278 citations

Ca2+ homeostasis in permeabilized human neutrophils. Characterization of Ca2+-sequestering pools and the action of inositol 1,4,5-triphosphate.

1984 • 266 citations

Separation and purification of a potent bactericidal/permeability-increasing protein and a closely associated phospholipase A2 from rabbit polymorphonuclear leukocytes. Observations on their relationship.

1979 • 247 citations

Arachidonic acid metabolism by human monocytes. Studies with platelet-depleted cultures.

1983 • 238 citations

Structure of porcine pancreatic phospholipase A2 at 2·6resolution and comparison with bovine phospholipase A2

1983 • 233 citations

The reticuloendothelial system: A comprehensive treatise

1984 • 224 citations

Phospholipid metabolism by phagocytic cells. Phospholipases A2 associated with rabbit polymorphonuclear leukocyte granules

1974 • 222 citations

Effect of phorbol 12-myristate 13-acetate and its analogue 4 alpha-phorbol 12,13-didecanoate on protein phosphorylation and lysosomal enzyme release in rabbit neutrophils.

1984 • 221 citations

The refined crystal structure of dimeric phospholipase A2 at 2.5 A. Access to a shielded catalytic center.

1985 • 213 citations

Bacterial lipopolysaccharides prime macrophages for enhanced release of arachidonic acid metabolites.

1986 • 211 citations

Plasma Membrane Synthesis in the Macrophage following Phagocytosis of Polystyrene Latex Particles

1972 • 208 citations

Interaction of phospholipase A₂ with micellar interfaces. Role of the N-terminal region

1975 • 206 citations

Quantitation of metal cations bound to membranes and extracted lipopolysaccharide of Escherichia coli

1983 • 181 citations

Stimulus response coupling in the human neutrophil. I. Kinetic analysis of changes in calcium permeability.

1984 • 177 citations

9 Phospholipases

1983 • 159 citations

Correlation of Enzymatic Activity and Anticoagulant Properties of Phospholipase A₂

1980 • 147 citations

A Reevaluation of the Roles of the O2-Dependent and O2-Independent Microbicidal Systems of Phagocytes

1983 • 143 citations

A cytosolic phospholipase in human neutrophils that hydrolyzes arachidonoyl-containing phosphatidylcholine

1986 • 137 citations

Structural and functional properties of a phospholipase A2 purified from an inflammatory exudate

1986 • 134 citations

CHOLESTEROL METABOLISM IN THE MACROPHAGE

1972 • 128 citations

The Primary Structure of Bovine Pancreatic Phospholipase A₂

1978 • 116 citations

Novel intestinal phospholipase A2: purification and some molecular characteristics

1982 • 113 citations

Approaches to the study of mammalian cellular phospholipases.

1985 • 112 citations

Dissociation of enzymatic activity from lethality and pharmacological properties by carbamylation of lysines in Naja nigricollis and Naja naja atra snake venom phospholipases A2

1981 • 101 citations

The Killing of Pathogens by Phagocytes

1981 • 101 citations

The role of lipopolysaccharides in the action of the bactericidal/permeability-increasing neutrophil protein on the bacterial envelope.

1984 • 94 citations

Degradation of Microorganisms by Phagocytic Cells

1980 • 94 citations

The 2.5 A crystal structure of a dimeric phospholipase A2 from the venom of Crotalus atrox.

1981 • 91 citations

Probing the phagolysosomal environment of human macrophages with a Ca2+-responsive operon fusion in Yersinia pestis

1986 • 91 citations

CHOLESTEROL METABOLISM IN THE MACROPHAGE

1971 • 88 citations

CHOLESTEROL METABOLISM IN THE MACROPHAGE

1971 • 87 citations

Isolation and characterization of a phospholipase A2 from an inflammatory exudate

1978 • 85 citations

Uptake and deacylation of bacterial lipopolysaccharides by macrophages from normal and endotoxin-hyporesponsive mice

1985 • 83 citations

Role of Charge and Hydrophobic Interactions in the Action of Bactericidal/Permeability-increasing Protein of Neutrophils on Gram-negative Bacteria

1983 • 83 citations

Increased synthesis of phospholipid during phagocytosis

1968 • 81 citations

Chemical modification of lysine and histidine residues in phospholipase A2 from the venom of Naja naja atra (Taiwan cobra)

1981 • 81 citations

Phospholipid metabolism by phagocytic cells

1966 • 79 citations

Molecular cloning of pldA, the structural gene for outer membrane phospholipase of E. coli K12

1983 • 69 citations

Phospholipase A activity associated with membranes of human polymorphonuclear leucocytes

1977 • 67 citations

Some properties of phospholipases of alveolar macrophages

1973 • 62 citations

Chapter 24. Platelet Activating Factor (PAF), A Novel Type of Phospholipid with Diverse Biological Properties

1982 • 62 citations

Crotalus atrox phospholipase A2. Amino acid sequence and studies on the function of the NH2-terminal region.

1982 • 57 citations

Metabolism of phospholipids by polymorphonuclear leukocytes

1965 • 57 citations

Activation of porcine pancreatic phospholipase A2 by the presence of negative charges at the lipid-water interface

1986 • 53 citations

Amino acid sequence of a basic Agkistrodon halys blomhoffii phospholipase A2. Possible role of amino-terminal lysines in action on phospholipids of Escherichia coli

1986 • 50 citations

Phospholipase A₂ activity in the plasma membrane of human polymorphonuclear leukocytes

1981 • 50 citations

Ribonuclease inhibitor from human placenta: interaction with derivatives of ribonuclease A.

1979 • 46 citations

Lysophospholipase and lysophosphatidylcholine:Lysophosphatidylcholine transacylase from rat lung: Evidence for a single enzyme and some aspects of its specificity

1978 • 46 citations

On the relationship between formylmethionyl-leucyl-phenylalanine stimulation of arachidonyl phosphatidylinositol turnover and lysosomal enzyme secretion by rabbit neutrophils.

1981 • 38 citations

The Reaction of Cyanate with the a and b Subunits in Hemoglobin

1973 • 37 citations

Activation of (arachidonyl) phosphatidylinositol turnover in rabbit neutrophils by the calcium ionophore A23187

1981 • 37 citations

Metabolism of lysophosphatidyl ethanolamine and lysophosphatidyl choline by homogenates of rabbit polymorphonuclear leukocytes and alveolar macrophages

1967 • 35 citations

Inflammation: Basic principles and clinical correlates

1988 • 35 citations

The appearance of lecithin-32P, synthesized from lysolecithin-32P, in phagosomes of polymorphonuclear leukocytes

1972 • 31 citations

The role of intramembrane Ca2+ in the hydrolysis of the phospholipids of Escherichia coli by Ca2+-dependent phospholipases.

1985 • 31 citations

Conformational studies of aqueous melittin: determination of ionization constants of lysine-21 and lysine-23 by reactivity toward 2,4,6-trinitrobenzenesulfonate

1983 • 25 citations

Carbamylation with cyanate of basic phospholipase A2 from the venom of Naja nigricollis (Spitting cobra)

1981 • 24 citations

The role of phospholipase A2 lysines in phospholipolysis of Escherichia coli killed by a membrane-active neutrophil protein.

1982 • 22 citations

Lipid metabolism by phagocytes.

1972 • 19 citations

Semisynthesis of Phospholipase A₂

1983 • 18 citations

Characteristics of Detergent-Resistant Phospholipase A Overproduced in E. coli Cells Bearing Its Cloned Structural Gene1

1984 • 17 citations

Purified phospholipase A2 from sheep erythrocyte membrane

1979 • 13 citations

Identification and Cloning of the Gene Coding for Lysophospholipase L2 of E. coli K-121

1983 • 9 citations

Biogenesis of the outer membrane of Salmonella.

1982 • 9 citations