Chapter 24. Platelet Activating Factor (PAF), A Novel Type of Phospholipid with Diverse Biological Properties

Platelet-activating factor. Evidence for 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine as the active component (a new class of lipid chemical mediators).

1979 • 1,203 citations

Antihypertensive activity of an alkyl ether analog of phosphatidylcholine

1979 • 562 citations

Physicochemical and Functional Identity of Rabbit Platelet-Activating Factor (PAF) Released in Vivo during IgE Anaphylaxis with PAF Released in Vitro from IgE Sensitized Basophils

1979 • 454 citations

A specific acetylhydrolase for 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (a hypotensive and platelet-activating lipid).

1981 • 440 citations

Ether Lipids Chemistry and Biology

1972 • 437 citations

Platelet-activating factor induces a platelet-dependent bronchoconstriction unrelated to the formation of prostaglandin derivatives

1980 • 422 citations

Identification of platelet activating factor isolated from rabbit basophils as acetyl glyceryl ether phosphorylcholine.

1980 • 408 citations

Activation of human neutrophils with 1-O-hexadecyl/octadecyl-2-acetyl-sn-glycerol-3-phosphorylcholine (platelet activating factor).

1981 • 390 citations

BACKGROUND AND PRESENT STATUS OF RESEARCH ON PLATELET‐ACTIVATING FACTOR (PAF‐ACETHER)

1981 • 332 citations

Enzymatic synthesis of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine, a hypotensive and platelet-aggregating lipid.

1980 • 321 citations

A New Pteridine-requiring Enzyme System for the Oxidation of Glyceryl Ethers

1964 • 294 citations

Phosphatidate and oxidized fatty acids are calcium ionophores. Studies employing arsenazo III in liposomes.

1981 • 293 citations

Human neutrophil-derived platelet activating factor.

1980 • 260 citations

Pathobiology of the intravenous infusion of acetyl glyceryl ether phosphorylcholine (AGEPC), a synthetic platelet-activating factor (PAF), in the rabbit.

1980 • 259 citations

Platelet‐activating factor and macrophages. I. Evidence for the release from rat and mouse peritoneal macrophages and not from mastocytes

1979 • 244 citations

1-O-Alkyl-sn-glyceryl-3-phosphorylcholines: a novel class of neutrophil stimulants.

1981 • 237 citations

Release of platelet-activating factor (PAF) and histamine. II. The cellular origin of human PAF: monocytes, polymorphonuclear neutrophils and basophils.

1981 • 225 citations

Aggregation of rabbit platelets by platelet-activating factor is independent of the release reaction and the arachidonate pathway and inhibited by membrane-active drugs.

1979 • 217 citations

The Release of a Platelet-Activating Factor by Stimulated Rabbit Neutrophils

1979 • 214 citations

Preliminary studies of an acid-labile factor (ALF) in human sera that inactivates platelet-activating factor (PAF)

1980 • 207 citations

Biosynthesis of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor and a hypotensive lipid) by cholinephosphotransferase in various rat tissues

1981 • 200 citations

Human platelet stimulation by acetyl glyceryl ether phosphorylcholine.

1981 • 199 citations

Platelet‐Activating Factor (PAF‐Acether) Secretion from Platelets: Effect of Aggregating Agents

1980 • 195 citations

Release of platelet‐activating factor (PAF‐acether) from alveolar macrophages by the calcium ionophore A 23187 and phagocytosis

1980 • 186 citations

Biosynthesis of platelet-activating factor

1982 • 185 citations

Novel effects of 1-0-hexadecyl-2-acyl-sn-glycero-3-phosphorylcholine mediators on human leukocyte function: Delineation of the specific roles of the acyl substituents

1980 • 150 citations

Contraction of guinea pig ileal smooth muscle by acetyl glyceryl ether phosphorylcholine

1981 • 134 citations

Physical and chemical properties of platelet-activating factor obtained from human neutrophils and monocytes and rabbit neutrophils and basophils

1980 • 131 citations

Platelet activating factor (PAF‐acether): total synthesis of 1‐O‐octadecyl 2‐O‐acetyl sn‐glycero‐3‐phosphoryl choline

1980 • 120 citations

Mediators of Immune-Complex-Induced Aggregation of Polymorphonuclear Neutrophils

1981 • 118 citations

Biosynthetic labelling of platelet activating factor from radioactive acetate by stimulated platelets

1981 • 117 citations

Ether lipid content and fatty acid distribution in rabbit polymorphonuclear neutrophil phospholipids

1982 • 116 citations

The biocleavage of alkyl glyceryl ethers in Morris hepatomas and other transplantable neoplasms.

1970 • 115 citations

Modification of the polar head group of acetyl glyceryl ether phosphorylcholine and subsequent effects upon platelet activation.

1981 • 114 citations

Anaphylactic actions of platelet-activating factor.

1981 • 108 citations

Platelet-activating factor in anaphylaxis and phagocytosis. I. Release from human peripheral polymorphonuclears and monocytes during the stimulation by ionophore A23187 and phagocytosis but not from degranulating basophils.

1980 • 102 citations

Production and release of platelet-activating factor (PAF); dissociation from degranulation and superoxide production in the human neutrophil.

1980 • 95 citations

Stereospecific activity of 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine and comparison of analogs in the degranulation of platelets and neutrophils

1981 • 95 citations

New total synthesis and high resolution 1H NMR spectrum of platelet-activating factor, its enantiomer and racemic mixtures

1981 • 88 citations

1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor) stimulates calcium influx in rabbit platelets

1981 • 88 citations

Antihypertensive polar renomedullary lipid, a semisynthetic vasodilator.

1979 • 85 citations

Activation of rabbit platelet phospholipase and thromboxane synthesis by 1-o-hexadecyl/octadecyl-2-acetyl-sn-glyceryl-3-phosphorylcholine (platelet activating factor)

1981 • 83 citations

Basophil-derived platelet-activating factor (PAF) as an in vivo mediator of acute allergic reactions: demonstration of specific desensitization of platelets to PAF during IgE-induced anaphylaxis in the rabbit.

1977 • 83 citations

Release of 1-O-alkylglyceryl 3-phosphorylcholine, O-deacetyl platelet-activating factor, from leukocytes: chemical ionization mass spectrometry of phospholipids.

1980 • 79 citations

Platelet-activating factor (PAF-acether) and macrophages

1981 • 74 citations

Acetyl glyceryl ether phosphorylcholine. Intravascular alterations following intravenous infusion into the baboon.

1981 • 74 citations

Potent platelet stimulating activity of enantiomers of acetyl glyceryl ether phosphorylcholine and its methoxy analogues

1981 • 73 citations

Platelet Activating Factor (PAF) Induced Release of Platelet Factor 4 (PF4) in vitro and during IgE Anaphylaxis in the Rabbit

1979 • 72 citations

In vivo metabolism of a new class of biologically active phospholipids: 1-alkyl-2-acetyl--glycero-3-phosphocholine, a platelet activating-hypotensive phospholipid

1981 • 71 citations

Partial Characterization of the Alkylglycerol Cleavage Enzyme System of Rat Liver

1972 • 71 citations

Selective desensitization of neutrophils: further studies with 1-O-alkyl-sn-glycero-3-phosphocholine analogues.

1981 • 64 citations

Influence of alkyl ether chain length of acetyl glyceryl ether phosphorylcholine and its ethanolamine analog on biological activity toward rabbit platelets

1981 • 63 citations

Tetrahydropteridine-dependent cleavage enzyme for O-alkyl lipids: substrate specificity

1973 • 63 citations

Substrate specificity in the biocleavage of the O-alkyl bond: 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (a hypotensive and platelet-activating lipid) and its metabolites

1981 • 58 citations

Evidence for 5,12-dihydroxy-6,8,10,14-eicosatetraenoate as a mediator of human neutrophil aggregation

1981 • 57 citations

Generation and release of platelet-activating factor (PAF) from enriched preparations of rabbit basophils; failure of human basophils to release PAF.

1980 • 53 citations

Basophil-Derived Platelet-Activating Factor (PAF) as an in Vivo Mediator of Acute Allergic Reactions: Demonstration of Specific Desensitization of Platelets to PAF during IgE-Induced Anaphylaxis in the Rabbit

1977 • 52 citations

A facile method for the preparation of 1-O-alkyl-2-O-acetoyl-sn-glycero-3-phosphocholines (platelet activating factor)

1981 • 50 citations

Release of platelet-activating factor in human pathology. I. Evidence for the occurrence of basophil degranulation and release of platelet-activating factor in systemic lupus erythematosus.

1981 • 49 citations

The binding of rabbit basophil-derived platelet-activating factor to rabbit platelets.

1980 • 47 citations

Platelet-activating factor

1980 • 42 citations

Role of Prostaglandin Synthesis in Rabbit Platelet Activation Induced by Basophil-Derived Platelet-Activating Factor

1978 • 41 citations

The mechanism of ether bond formation in O-alkyl lipid synthesis.

1980 • 29 citations

Desensitization of the human neutrophil degranulation response: Studies with 5,12-dihydroxy-6,8,10,14-eicosatetraenoic acid

1981 • 29 citations

Role of extracellular calcium and neutrophil degranulation responses to 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine.

1981 • 28 citations

The enzymatic exchange of the acyl group of acyl dihydroxyacetone phosphat with free fatty acids.

1977 • 25 citations

Effect of prostacyclin on platelet-activating factor induced rabbit platelet aggregation

1980 • 24 citations

The enzymatic exchange of the acyl group of acyl dihydroxyacetone phosphate with free fatty acids

1977 • 21 citations

Hydrogen exchange in the formation of dihydroxyacetone phosphate from acyl dihydroxyacetone phosphate in O-alkyl lipid synthesis in Ehrlich ascites tumor cell microsomes.

1981 • 17 citations

The binding of platelet-activating factor (PAF) to polymorphonuclear neutrophils (PMN) as a trigger for the immune-induced PMN aggregation.

1980 • 12 citations

Platelet-activating factor (PAF) release from rat peritoneal cells, evidence for mastocyte-macrophage cooperation.

1980 • 3 citations

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