An extensive network of PHFτ‐rich dystrophic neurites permeates neocortex and nearly all neuritic and diffuse amyloid plaques in Alzheimer disease

Diagnosis of Alzheimer's Disease

1985 • 2,482 citations

Multiple isoforms of human microtubule-associated protein tau: sequences and localization in neurofibrillary tangles of Alzheimer's disease

1989 • 2,308 citations

Seeding “one-dimensional crystallization” of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?

1993 • 2,146 citations

Amyloid β-peptide is produced by cultured cells during normal metabolism

1992 • 1,888 citations

Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids

1992 • 1,701 citations

The distribution of tau in the mammalian central nervous system.

1985 • 1,518 citations

Production of the Alzheimer Amyloid β Protein by Normal Proteolytic Processing

1992 • 1,438 citations

A68: a Major Subunit of Paired Helical Filaments and Derivatized Forms of Normal Tau

1991 • 1,397 citations

Tau proteins of alzheimer paired helical filaments: Abnormal phosphorylation of all six brain isoforms

1992 • 1,058 citations

Abnormal tau phosphorylation at Ser396 in alzheimer's disease recapitulates development and contributes to reduced microtubule binding

1993 • 856 citations

Expression of separate isoforms of human tau protein: correlation with the tau pattern in brain and effects on tubulin polymerization.

1990 • 849 citations

A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis.

1990 • 715 citations

A Neuronal Antigen in the Brains of Alzheimer Patients

1986 • 577 citations

Hydrofluoric acid-treated tau PHF proteins display the same biochemical properties as normal tau.

1992 • 509 citations

Epitopes that span the tau molecule are shared with paired helical filaments

1988 • 494 citations

Phosphorylation determines two distinct species of tau in the central nervous system

1987 • 405 citations

The car☐yl third of tau is tightly bound to paired helical filaments

1988 • 342 citations

Distribution of tau proteins in the normal human central and peripheral nervous system.

1989 • 314 citations

Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides.

1993 • 223 citations

High affinity interactions between the Alzheimer's beta-amyloid precursor proteins and the basement membrane form of heparan sulfate proteoglycan

1991 • 211 citations

The Seminal Role of β-Amyloid in the Pathogenesis of Alzheimer Disease

1992 • 182 citations

Monoclonal Antibodies to Gel‐Excised Glial Filament Protein and Their Reactivities with Other Intermediate Filament Proteins

1984 • 168 citations

Epitope map of neurofilament protein domains in cortical and peripheral nervous system Lewy bodies.

1991 • 161 citations

Defined neurofilament, tau, and beta-amyloid precursor protein epitopes distinguish Alzheimer from non-Alzheimer senile plaques.

1990 • 154 citations

Characterization of high affinity binding between laminin and Alzheimer's disease amyloid precursor proteins.

1992 • 128 citations

Regions with abundant neurofibrillary pathology in human brain exhibit a selective reduction in levels of binding-competent tau and accumulation of abnormal tau-isoforms (A68 proteins).

1992 • 113 citations

Re-Evaluation of the Structural Organization of Neuritic Plaques in Alzheimerʼs Disease

1993 • 102 citations

Localization of the mitogen activated protein kinase ERK2 in Alzheimer's disease neurofibrillary tangles and senile plaque neurites

1993 • 90 citations

Immunological and conformational characterization of a phosphorylated immunodominant epitope on the paired helical filaments found in Alzheimer's disease

1992 • 85 citations

Comparative epitope analysis of neuronal cytoskeletal proteins in Alzheimer's disease senile plaque neurites and neuropil threads.

1991 • 82 citations

Amyloid plaques in cerebellar cortex and the integrity of Purkinje cell dendrites

1994 • 75 citations

Tau Proteins Are Abnormally Expressed in Olfactory Epithelium of Alzheimer Patients and Developmentally Regulated in Human Fetal Spinal Cord

1993 • 74 citations

Confocal microscopy: an overview.

1989 • 68 citations

Molecular features of hypothalamic plaques in Alzheimer's disease.

1991 • 60 citations

Is the "preamyloid" of diffuse plaques in Alzheimer's disease really nonfibrillar?

1993 • 48 citations

Alzheimer disease A68 proteins injected into rat brain induce codeposits of beta-amyloid, ubiquitin, and alpha 1-antichymotrypsin.

1993 • 45 citations

Continuity of neuropil threads with tangle-bearing and tangle-free neurons in Alzheimer disease cortex

1993 • 20 citations

Association of the carboxy-terminus of β-amyloid protein precursor with Alzheimer paired helical filaments

1992 • 20 citations

Chapter 24. Amyloidogenesis as a Therapeutic Target in Alzheimer's Disease

1991 • 15 citations

REVIEW

1993 • 14 citations