Global Natural Regulatory T Cell Depletion in Active Systemic Lupus Erythematosus

The 1982 revised criteria for the classification of systemic lupus erythematosus

1982 • 14,553 citations

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

2003 • 7,902 citations

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

2003 • 7,470 citations

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

Classification criteria for Sjogren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group

2002 • 5,065 citations

Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival

2004 • 4,872 citations

Derivation of the sledai. A disease activity index for lupus patients

1992 • 4,410 citations

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

1997 • 3,625 citations

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

2001 • 3,260 citations

An essential role for Scurfin in CD4+CD25+ T regulatory cells

2003 • 2,825 citations

Naturally arising Foxp3-expressing CD25+CD4+ regulatory T cells in immunological tolerance to self and non-self

2005 • 2,667 citations

CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production

1998 • 2,658 citations

Immunologic Self-Tolerance Maintained by Cd25+Cd4+Regulatory T Cells Constitutively Expressing Cytotoxic T Lymphocyte–Associated Antigen 4

2000 • 2,207 citations

CD4+CD25+ suppressor T cells: more questions than answers

2002 • 2,202 citations

B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes

2000 • 2,090 citations

CD4+CD25high Regulatory Cells in Human Peripheral Blood

2001 • 1,882 citations

Loss of Functional Suppression by CD4+CD25+ Regulatory T Cells in Patients with Multiple Sclerosis

2004 • 1,835 citations

Antinuclear Antibodies: Diagnostic Markers for Autoimmune Diseases and Probes for Cell Biology

1989 • 1,543 citations

Immunologic tolerance maintained by CD25⁺ CD4⁺ regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance

2001 • 1,515 citations

Induction of Tumor Immunity by Removing CD25+CD4+ T Cells: A Common Basis Between Tumor Immunity and Autoimmunity

1999 • 1,475 citations

Natural versus adaptive regulatory T cells

2003 • 1,363 citations

Identification and Functional Characterization of Human Cd4+Cd25+ T Cells with Regulatory Properties Isolated from Peripheral Blood

2001 • 1,293 citations

Compromised Function of Regulatory T Cells in Rheumatoid Arthritis and Reversal by Anti-TNFα Therapy

2004 • 1,242 citations

Regulatory T cells in the control of immune pathology

2001 • 1,197 citations

Ex Vivo Isolation and Characterization of Cd4+Cd25+ T Cells with Regulatory Properties from Human Blood

2001 • 1,168 citations

A COMPUTER-ASSISTED ANALYSIS OF 153 PATIENTS WITH POLYMYOSITIS AND DERMATOMYOSITIS

1977 • 1,027 citations

Human Cd25+Cd4+ T Regulatory Cells Suppress Naive and Memory T Cell Proliferation and Can Be Expanded in Vitro without Loss of Function

2001 • 1,008 citations

A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3

2005 • 957 citations

Induction and mechanism of action of transforming growth factor‐β‐secreting Th3 regulatory cells

2001 • 856 citations

Defective Suppressor Function in CD4+CD25+ T-Cells From Patients With Type 1 Diabetes

2005 • 825 citations

Impaired phagocytosis of apoptotic cell material by monocyte-derived macrophages from patients with systemic lupus erythematosus

1998 • 825 citations

Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome

2002 • 703 citations

Dubois' Lupus Erythematosus

1988 • 675 citations

Homeostasis and anergy of CD4+CD25+ suppressor T cells in vivo

2001 • 658 citations

Human CD4+CD25+ cells: a naturally occurring population of regulatory T cells

2001 • 615 citations

Dysfunctional Blood and Target Tissue CD4+CD25high Regulatory T Cells in Psoriasis: Mechanism Underlying Unrestrained Pathogenic Effector T Cell Proliferation

2005 • 561 citations

Human CD4+CD25+ thymocytes and peripheral T cells have immune suppressive activityin vitro

2001 • 498 citations

B cells and professional APCs recruit regulatory T cells via CCL4

2001 • 496 citations

Human anergic/suppressive CD4+CD25+ T cells: a highly differentiated and apoptosis-prone population

2001 • 460 citations

Isolation and functional characterization of regulatory CD25^brightCD4⁺ T cells from the target organ of patients with rheumatoid arthritis

2003 • 452 citations

Quantification of regulatory T cells in patients with systemic lupus erythematosus

2003 • 417 citations

CD4+CD25bright Regulatory T Cells Actively Regulate Inflammation in the Joints of Patients with the Remitting Form of Juvenile Idiopathic Arthritis

2004 • 403 citations

Phenotype, Localization, and Mechanism of Suppression of CD4+CD25+ Human Thymocytes

2002 • 384 citations

Defective Suppressor Function of Human CD4+ CD25+ Regulatory T Cells in Autoimmune Polyglandular Syndrome Type II

2004 • 359 citations

CD25brightCD4+regulatory T cells are enriched in inflamed joints of patients with chronic rheumatic disease

2004 • 354 citations

Decreased CD4⁺CD25⁺ T Cells in Peripheral Blood of Patients with Systemic Lupus Erythematosus

2004 • 286 citations

Natural regulatory T cells and self-tolerance

2005 • 234 citations

Characterization of human CD25⁺ CD4⁺ T cells in thymus, cord and adult blood

2002 • 232 citations

Depletion of CD25(+) CD4(+) T cells and treatment with tyrosinase-related protein 2-transduced dendritic cells enhance the interferon alpha-induced, CD8(+) T-cell-dependent immune defense of B16 melanoma.

2001 • 223 citations

CD4+CD25+ regulatory T-cell deficiency in patients with hepatitis C-mixed cryoglobulinemia vasculitis

2003 • 221 citations

The Impact of T Helper and T Regulatory Cells on the Regulation of Anti-Double-Stranded DNA B Cells

2002 • 220 citations

Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV

2005 • 216 citations

Chronic graft-versus-host disease is associated with increased numbers of peripheral blood CD4+CD25high regulatory T cells

2003 • 214 citations

High levels of circulating early apoptic peripheral blood mononuclear cells in systemic lupus erythematosus

1998 • 210 citations

Antigen-induced regulatory T cells

2004 • 120 citations

Skin‐versus gut‐skewed homing receptor expression and intrinsic CCR4 expression on human peripheral blood CD4⁺CD25⁺ suppressor T cells

2003 • 112 citations

Modulation of Fas-Dependent Apoptosis: A Dynamic Process Controlling Both the Persistence and Death of CD4 Regulatory T Cells and Effector T Cells

2002 • 112 citations

Regulation by CD25+ lymphocytes of autoantigen-specific T-cell responses in Goodpasture's (anti-GBM) disease

2003 • 111 citations

Adenovirus-transduced dendritic cells stimulate cellular immunity to melanoma via a CD4+ T cell-dependent mechanism

2001 • 83 citations

Dubois' Lupus Erythematosus, 6th ed

2003 • 54 citations

Increase of circulating CD4+CD25+ T cells in myasthenia gravis patients with stability and thymectomy

2004 • 45 citations

Circulating CD4⁺CD25⁺ and CD4⁺CD25⁻ T Cells in Myasthenia Gravis

2003 • 5 citations

Deleted Work

1955 • 0 citations