Sumoylation of the Transcriptional Intermediary Factor 1β (TIF1β), the Co-repressor of the KRAB Multifinger Proteins, Is Required for Its Transcriptional Activity and Is Modulated by the KRAB Domain

SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins

2002 • 1,207 citations

Functional Heterogeneity of Small Ubiquitin-related Protein Modifiers SUMO-1 versus SUMO-2/3

2000 • 848 citations

Polymeric Chains of SUMO-2 and SUMO-3 Are Conjugated to Protein Substrates by SAE1/SAE2 and Ubc9

2001 • 782 citations

SUMO—Nonclassical Ubiquitin

2000 • 764 citations

SUMO and ubiquitin in the nucleus: different functions, similar mechanisms?

2004 • 744 citations

Differential transcriptional activation by Oct-1 and Oct-2: Interdependent activation domains induce Oct-2 phosphorylation

1990 • 696 citations

Histone sumoylation is associated with transcriptional repression

2003 • 668 citations

KAP-1, a novel corepressor for the highly conserved KRAB repression domain.

1996 • 637 citations

The Polycomb Protein Pc2 Is a SUMO E3

2003 • 558 citations

PIASy, a nuclear matrix–associated SUMO E3 ligase, represses LEF1 activity by sequestration into nuclear bodies

2001 • 538 citations

A possible involvement of TIF1 alpha and TIF1 beta in the epigenetic control of transcription by nuclear receptors.

1996 • 532 citations

Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2α subunit of NuRD

2001 • 504 citations

The Mechanisms of PML-Nuclear Body Formation

2006 • 493 citations

Something about SUMO inhibits transcription

2005 • 491 citations

KRAB-containing zinc-finger repressor proteins.

2003 • 489 citations

Insights into E3 ligase activity revealed by a SUMO–RanGAP1–Ubc9–Nup358 complex

2005 • 473 citations

Quantitative Assessment of β1- and β2-Adrenergic Receptor Homo- and Heterodimerization by Bioluminescence Resonance Energy Transfer

2002 • 466 citations

p300 Transcriptional Repression Is Mediated by SUMO Modification

2003 • 447 citations

Modification with SUMO

2003 • 429 citations

PIAS Proteins Modulate Transcription Factors by Functioning as SUMO-1 Ligases

2002 • 420 citations

Structure determination of the small ubiquitin-related modifier SUMO-1

1998 • 415 citations

Role of SUMO-Interacting Motif in Daxx SUMO Modification, Subnuclear Localization, and Repression of Sumoylated Transcription Factors

2006 • 413 citations

RING domains: master builders of molecular scaffolds?

2000 • 396 citations

SUMO: ligases, isopeptidases and nuclear pores

2003 • 387 citations

Generation of protein-reactive antibodies by short peptides is an event of high frequency: implications for the structural basis of immune recognition.

1983 • 378 citations

The evolutionarily conserved Krüppel-associated box domain defines a subfamily of eukaryotic multifingered proteins.

1991 • 368 citations

SUMO-1 Modification Represses Sp3 Transcriptional Activation and Modulates Its Subnuclear Localization

2002 • 365 citations

Regulated recruitment of HP1 to a euchromatic gene induces mitotically heritable, epigenetic gene silencing: a mammalian cell culture model of gene variegation

2003 • 362 citations

A M55V Polymorphism in a Novel SUMO Gene (SUMO-4) Differentially Activates Heat Shock Transcription Factors and Is Associated with Susceptibility to Type I Diabetes Mellitus

2004 • 356 citations

Interaction with members of the heterochromatin protein 1 (HP1) family and histone deacetylation are differentially involved in transcriptional silencing by members of the TIF1 family

1999 • 352 citations

The Krüppel-associated box-A (KRAB-A) domain of zinc finger proteins mediates transcriptional repression.

1994 • 346 citations

SUMO Promotes HDAC-Mediated Transcriptional Repression

2004 • 339 citations

Histone sumoylation is a negative regulator in Saccharomyces cerevisiae and shows dynamic interplay with positive-acting histone modifications

2006 • 323 citations

The SUMO E3 ligase RanBP2 promotes modification of the HDAC4 deacetylase

2002 • 316 citations

Identification of Three Major Sentrinization Sites in PML

1998 • 305 citations

The KAP1 Corepressor Functions To Coordinate the Assembly of De Novo HP1-Demarcated Microenvironments of Heterochromatin Required for KRAB Zinc Finger Protein-Mediated Transcriptional Repression

2006 • 299 citations

A novel member of the RING finger family, KRIP-1, associates with the KRAB-A transcriptional repressor domain of zinc finger proteins

1996 • 278 citations

Transcriptional Repression by RING Finger Protein TIF1 That Interacts with the KRAB Repressor Domain of KOX1

1996 • 277 citations

Dynamic Interplay of the SUMO and ERK Pathways in Regulating Elk-1 Transcriptional Activity

2003 • 252 citations

In VitroSUMO-1 Modification Requires Two Enzymatic Steps, E1 and E2

1999 • 224 citations

Sumoylation of the Estrogen Receptor α Hinge Region Regulates Its Transcriptional Activity

2005 • 222 citations

Post-translational modification by the small ubiquitin-related modifier SUMO has big effects on transcription factor activity

2003 • 220 citations

Mice lacking the transcriptional corepressor TIF1β are defective in early postimplantation development

2000 • 206 citations

The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain

2005 • 202 citations

Molecular Determinants for Targeting Heterochromatin Protein 1-Mediated Gene Silencing: Direct Chromoshadow Domain–KAP-1 Corepressor Interaction Is Essential

2000 • 202 citations

Solution structure of the PHD domain from the KAP-1 corepressor: structural determinants for PHD, RING and LIM zinc-binding domains

2001 • 197 citations

Reconstitution of the KRAB-KAP-1 repressor complex: a model system for defining the molecular anatomy of RING-B box-coiled-coil domain-mediated protein-protein interactions

2000 • 196 citations

Transcriptional Activity of Peroxisome Proliferator-activated Receptor γ Is Modulated by SUMO-1 Modification

2004 • 180 citations

Covalent Attachment of the SUMO-1 Protein to the Negative Regulatory Domain of the c-Myb Transcription Factor Modifies Its Stability and Transactivation Capacity

2002 • 178 citations

Opposed Regulation of Corepressor CtBP by SUMOylation and PDZ Binding

2003 • 169 citations

Characterization of the Localization and Proteolytic Activity of the SUMO-specific Protease, SENP1

2003 • 167 citations

SUMO and transcriptional regulation

2004 • 162 citations

TIF1γ, a novel member of the transcriptional intermediary factor 1 family

1999 • 161 citations

The RanBP2 SUMO E3 ligase is neither HECT- nor RING-type

2004 • 154 citations

Pc2-mediated Sumoylation of Smad-interacting Protein 1 Attenuates Transcriptional Repression of E-cadherin

2005 • 144 citations

Transcriptional Activity of CCAAT/Enhancer-binding Proteins Is Controlled by a Conserved Inhibitory Domain That Is a Target for Sumoylation

2002 • 143 citations

SUMO-1: wrestling with a new ubiquitin-related modifier

1997 • 143 citations

KRAB Zinc Finger Proteins: An Analysis of the Molecular Mechanisms Governing Their Increase in Numbers and Complexity During Evolution

2002 • 123 citations

Common Properties of Nuclear Body Protein SP100 and TIF1α Chromatin Factor: Role of SUMO Modification

2001 • 123 citations

Repression of Smad4 transcriptional activity by SUMO modification

2004 • 110 citations

Involvement of the rfp tripartite motif in protein-protein interactions and subcellular distribution

1997 • 107 citations

NXP-2 association with SUMO-2 depends on lysines required for transcriptional repression

2006 • 106 citations

Association of the transcriptional corepressor TIF1β with heterochromatin protein 1 (HP1): an essential role for progression through differentiation

2004 • 104 citations

TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1

2001 • 104 citations

Cell differentiation induces TIF1β association with centromeric heterochromatin via an HP1 interaction

2002 • 98 citations

Bonus, a Drosophila Homolog of TIF1 Proteins, Interacts with Nuclear Receptors and Can Inhibit βFTZ-F1-Dependent Transcription

2001 • 95 citations

Hetero-oligomerization Among the TIF Family of RBCC/TRIM Domain-containing Nuclear Cofactors: A Potential Mechanism for Regulating the Switch Between Coactivation and Corepression

2002 • 88 citations

Role for SUMO Modification in Facilitating Transcriptional Repression by BKLF

2005 • 83 citations

A Small Conserved Surface in SUMO Is the Critical Structural Determinant of Its Transcriptional Inhibitory Properties

2005 • 79 citations

TIF1δ, a Novel HP1-interacting Member of the Transcriptional Intermediary Factor 1 (TIF1) Family Expressed by Elongating Spermatids

2004 • 78 citations

Coactivator TIF1β Interacts with Transcription Factor C/EBPβ and Glucocorticoid Receptor To Induce α1-Acid Glycoprotein Gene Expression

1998 • 74 citations

The KRAB Zinc Finger Gene Encodes an RNA-binding Protein Tightly Associated with the Nuclear Matrix

1996 • 67 citations

Crystal structures of the human SUMO‐2 protein at 1.6 Å and 1.2 Å resolution

2004 • 66 citations

Oligomerization of Transcriptional Intermediary Factor 1 Regulators and Interaction with ZNF74 Nuclear Matrix Protein Revealed by Bioluminescence Resonance Energy Transfer in Living Cells

2003 • 58 citations

MafG Sumoylation Is Required for Active Transcriptional Repression

2006 • 56 citations

SUMOylation of the Corepressor N-CoR Modulates Its Capacity to Repress Transcription

2006 • 54 citations

The promyelocytic leukemia protein stimulates SUMO conjugation in yeast

2006 • 52 citations

SUMO Modification Enhances p66-Mediated Transcriptional Repression of the Mi-2/NuRD Complex

2006 • 50 citations

RBP1 Family Proteins Exhibit SUMOylation-Dependent Transcriptional Repression and Induce Cell Growth Inhibition Reminiscent of Senescence

2006 • 44 citations

Transcriptional activity of megakaryoblastic leukemia 1 (MKL1) is repressed by SUMO modification

2005 • 32 citations

Role of Ubiquitin-Like Proteins in Transcriptional Regulation

2006 • 28 citations

Transcriptional Repression Mediated by the KRAB Domain of the Human C2H2 Zinc Finger Protein Kox1/ZNF10 Does Not Require Histone Deacetylation

2001 • 28 citations

Repression of SOX6 transcriptional activity by SUMO modification

2006 • 27 citations

A New Clue at the Nuclear Pore

2002 • 22 citations

Beginning at the end with SUMO

2005 • 19 citations

Alternative Promoter Usage and Splicing ofZNF74Multifinger Gene Produce Protein Isoforms with a Different Repressor Activity and Nuclear Partitioning

2001 • 16 citations

Requirement of the coiled-coil domain of PML-RARα oncoprotein for localization, sumoylation, and inhibition of monocyte differentiation

2005 • 10 citations

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