Reducing the immunogenicity and improving the in vivo activity of trichosanthin by site-directed pegylation

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

An Efficient mRNA‐Dependent Translation System from Reticulocyte Lysates

1976 • 3,994 citations

Poly(ethylene glycol) chemistry : biotechnical and biomedical applications

1992 • 1,437 citations

Alteration of immunological properties of bovine serum albumin by covalent attachment of polyethylene glycol.

1977 • 1,311 citations

Effect of covalent attachment of polyethylene glycol on immunogenicity and circulating life of bovine liver catalase.

1977 • 1,239 citations

Antibodies against Polyethylene Glycol Produced in Animals by Immunization with Monomethoxy Polyethylene Glycol Modified Proteins

1983 • 269 citations

Relationship of effective molecular size to systemic clearance in rats of recombinant interleukin-2 chemically modified with water-soluble polymers.

1988 • 265 citations

Long-acting Growth Hormones Produced by Conjugation with Polyethylene Glycol

1996 • 245 citations

Biomedical and biotechnological applications of PEG- and PM-modified proteins

1995 • 224 citations

Adenosine deaminase deficiency with late onset of recurrent infections: Response to treatment with polyethylene glycol-modified adenosine deaminase

1988 • 217 citations

Polyethylene Glycol Reactive Antibodies in Man: Titer Distribution in Allergic Patients Treated with Monomethoxy Polyethylene Glycol Modified Allergens or Placebo, and in Healthy Blood Donors

1984 • 208 citations

Site-Directed Pegylation of Recombinant Interleukin-2 at its Glycosylation Site

1990 • 155 citations

Immunogenicity of recombinant IL-2 modified by covalent attachment of polyethylene glycol.

1990 • 136 citations

PCA Reactions with Mouse Antibodies in Mice and Rats

1975 • 122 citations

A phase I/II study of trichosanthin treatment of HIV disease

1990 • 116 citations

A Phase II Study of Effect of Addition of Trichosanthin to Zidovudine in Patients with HIV Disease and Failing Antiretroviral Agents

1994 • 85 citations

Advances in Chinese medicinal materials research

1985 • 80 citations

Minireview: Trichosanthin - a protein with multiple pharmacological properties

1994 • 69 citations

Molecular design of hybrid tumour necrosis factor alpha with polyethylene glycol increases its anti-tumour potency

1995 • 64 citations

Safety, activity, and pharmacokinetics of GLQ223 in patients with AIDS and AIDS-related complex

1994 • 60 citations

Polyethylene glycol-modified chimeric toxin composed of transforming growth factor alpha and Pseudomonas exotoxin.

1993 • 43 citations

Trichosanthin treatment of HIV‐induced immune dysregulation

1992 • 40 citations

Molecular design of hybrid tumor necrosis factor-alpha III: polyethylene glycol-modified tumor necrosis factor-alpha has markedly enhanced antitumor potency due to longer plasma half-life and higher tumor accumulation.

1996 • 39 citations

A preliminary study on the evaluation of asparaginase. Polyethylene glycol conjugate against canine malignant lymphoma

1987 • 39 citations

High level synthesis of biologically active recombinant trichosanthin in Escherichia coli

1992 • 37 citations

Polyethylene glycol (PEG) modification of granulocyte‐macrophage colony stimulating factor (GM‐CSF) enhances neutrophil priming activity but not colony stimulating activity

1992 • 35 citations

Clinical Trials with Dismutec™ (Pegorgotein; Polyethylene Glycol-Conjugated Superoxide Dismutase; PEG-SOD) in the Treatment of Severe Closed Head Injury

1994 • 28 citations

Increasing the plasma half-life of trichosanthin by coupling to dextran

1991 • 22 citations

Neurological reactions in HIV‐infected patients treated with trichosanthin

1993 • 20 citations

The biological activities of trichosanthin after coupling to dextran

1993 • 7 citations

Renal Reabsorption of Trichosanthin and the Effect on GFR

1994 • 3 citations