Interleukin-12: Role of Interferon-γ in IL-12 Adverse Effects

Interleukin-12: A Proinflammatory Cytokine with Immunoregulatory Functions that Bridge Innate Resistance and Antigen-Specific Adaptive Immunity

1995 • 2,437 citations

Immune Response in Mice that Lack the Interferon-γ Receptor

1993 • 1,570 citations

Antitumor and antimetastatic activity of interleukin 12 against murine tumors.

1993 • 1,206 citations

Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes

1994 • 1,066 citations

Recombinant IL-12 administration induces tumor regression in association with IFN-gamma production.

1994 • 796 citations

Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN-γ in vivo

1994 • 373 citations

Interferon gamma receptor deficient mice are resistant to endotoxic shock.

1994 • 293 citations

Effects of IL-12 on in vivo cytokine gene expression and Ig isotype selection.

1994 • 290 citations

Interleukin-12

1994 • 285 citations

The role of interleukin 12 in the immune response, disease and therapy

1994 • 221 citations

Role of interferon-gamma in interleukin 12-induced pathology in mice.

1995 • 122 citations

Cytotoxic lymphocyte maturation factor (interleukin 12) is a synergistic growth factor for hematopoietic stem cells.

1993 • 111 citations

The stimulatory effects of interleukin (IL)-12 on hematopoiesis are antagonized by IL-12-induced interferon gamma in vivo.

1995 • 86 citations

Biologic effects of recombinant human interleukin-12 in squirrel monkeys (Sciureus saimiri).

1994 • 82 citations

Dual stimulatory and inhibitory effect of NK cell stimulatory factor/IL-12 on human hematopoiesis.

1994 • 68 citations

Interleukin-12 and interferon-gamma. Do they always go together?

1995 • 55 citations

IL-12 at the Crossroads

1995 • 52 citations

Comparative Pathology of Recombinant Murine Interferon-γ in Mice and Recombinant Human Interferon-γ in Cynomolgus Monkeys

1993 • 47 citations