A neural plasticity hypothesis of schizophrenia

The Need for a New Medical Model: A Challenge for Biomedicine

1977 • 10,409 citations

A permanent change in brain function resulting from daily electrical stimulation

1969 • 3,056 citations

The period of susceptibility to the physiological effects of unilateral eye closure in kittens

1970 • 2,965 citations

Toward a theory of schizophrenia

2007 • 2,645 citations

Synaptic density in human frontal cortex — Developmental changes and effects of aging

1979 • 2,587 citations

Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic Drugs

1976 • 2,224 citations

Schizotaxia, schizotypy, schizophrenia.

1962 • 1,985 citations

Influence of Family Life on the Course of Schizophrenic Disorders: A Replication

1972 • 1,769 citations

The Influence of Family and Social Factors on the Course of Psychiatric Illness

1976 • 1,680 citations

Plasticity of ocular dominance columns in monkey striate cortex

1977 • 1,630 citations

Antipsychotic drug doses and neuroleptic/dopamine receptors

1976 • 1,623 citations

Peptidergic neurones

1980 • 1,523 citations

Supplementary motor area and other cortical areas in organization of voluntary movements in man

1980 • 1,509 citations

Frontiers in Catecholamine Research

1973 • 1,252 citations

CEREBRAL VENTRICULAR SIZE AND COGNITIVE IMPAIRMENT IN CHRONIC SCHIZOPHRENIA

1976 • 1,235 citations

Developmental Neurobiology

1978 • 1,211 citations

THE BRAIN’S RECORD OF AUDITORY AND VISUAL EXPERIENCE

1963 • 1,203 citations

The Measurement of Expressed Emotion in the Families of Psychiatric Patients

1976 • 1,046 citations

Neural mechanisms of learning and memory

1977 • 864 citations

The Dopamine Hypothesis of Schizophrenia: A Review*

1976 • 862 citations

The role of the limbic system in experiential phenomena of temporal lobe epilepsy

1982 • 843 citations

Psychopharmacology: A generation of progress

1978 • 785 citations

Chemical and Anatomical Plasticity of Brain

1964 • 757 citations

Schizophrenia and genetics : a twin study vantage point

1972 • 727 citations

Evidence for coexistence of dopamine and CCK in meso-limbic neurones

1980 • 696 citations

The Measurement of Family Activities and Relationships

1966 • 688 citations

Animal models in psychiatry and neurology

1978 • 648 citations

Patterns of localization in precentral and "supplementary" motor areas and their relation to the concept of a premotor area.

1952 • 576 citations

Synapses as associative memory elements in the hippocampal formation

1979 • 573 citations

Localization of Functional Activity in the Central Nervous System by Measurement of Glucose Utilization with Radioactive Deoxyglucose

1981 • 572 citations

Interchangeability of Stress and Amphetamine in Sensitization

1980 • 565 citations

The premotor cortex of the monkey

1982 • 564 citations

Long-term potentiation phenomena in the rat limbic forebrain

1983 • 562 citations

Synapse replacement in the nervous system of adult vertebrates.

1981 • 545 citations

Relationship of neuroleptic drug effects at brain dopamine, serotonin, alpha-adrenergic, and histamine receptors to clinical potency

1980 • 543 citations

Cerebral Glucography With Positron Tomography

1982 • 538 citations

Long-term potentiation of the perforant path-granule cell synapse in the rat hippocampus

1975 • 501 citations

Relationships among local functional activity, energy metabolism, and blood flow in the central nervous system.

1981 • 486 citations

Neuropathology of Schizophrenia

1982 • 472 citations

Dendritic Growth in the Aged Human Brain and Failure of Growth in Senile Dementia

1979 • 466 citations

Long-lasting morphological changes in dendritic spines of dentate granular cells following stimulation of the entorhinal area

1977 • 450 citations

Cocaine and Other Stimulants

1977 • 421 citations

Neuronal plasticity and memory formation

1982 • 416 citations

Increased Brain Dopamine and Dopamine Receptors in Schizophrenia

1982 • 393 citations

The schizophrenic disorders: Long-term patient and family studies

1978 • 379 citations

Progressive dendritic changes in aging human cortex

1975 • 367 citations

Synaptic plasticity in the hippocampus

1979 • 357 citations

General Systems Theory

2017 • 350 citations

Activation of the Supplementary Motor Area During Voluntary Movement in Man Suggests It Works as a Supramotor Area

1979 • 345 citations

Supplementary motor area in the monkey: activity of neurons during performance of a learned motor task

1979 • 338 citations

Computed Tomography in Schizophreniform Disorder and Other Acute Psychiatric Disorders

1982 • 326 citations

Amphetamine psychosis: Behavioral and biochemical aspects

1974 • 325 citations

“Hyperfrontal” distribution of the cerebral grey matter flow in resting wakefulness; on the functional anatomy of the conscious state

2009 • 321 citations

Cocaine, kindling, and psychosis

1976 • 315 citations

Electrical Studies on the Unanesthetized Brain

1961 • 314 citations

Increase of Food Intake Induced by Electrical Stimulation of the Lateral Hypothalamus

1952 • 313 citations

Cerebral Metabolism and Neural Function

1981 • 308 citations

The Schizophrenic Disorders: Long-Term Patient and Family Studies

1979 • 297 citations

Response to stress of mesocortico-frontal dopaminergic neurones in rats after long-term isolation

1980 • 296 citations

Dopamine Nerve Terminals in the Rat Limbic Cortex: Aspects of the Dopamine Hypothesis of Schizophrenia

1974 • 290 citations

Persistent Seizure Susceptibility and Recurrent Spontaneous Seizures in Kindled Cats

1974 • 289 citations

Cerebellar Plasticity: Modification of Purkinje Cell Structure by Differential Rearing in Monkeys

1979 • 287 citations

The kindling model of epilepsy: A review

1980 • 287 citations

The dementia of dementia praecox

1978 • 274 citations

Consequences of monocular deprivation on visual behaviour in kittens

1970 • 272 citations

Dopaminergic supersensitivity after neuroleptics: Time-course and specificity

1978 • 271 citations

The Role of Maintenance Therapy and Relatives' Expressed Emotion in Relapse of Schizophrenia: A Two-Year Follow-up

1981 • 268 citations

MOTHER‐INFANT SEPARATION IN MONKEYS*

1962 • 260 citations

Poor premorbid adjustment and CT scan abnormalities in chronic schizophrenia

1980 • 258 citations

An Independent Analysis of the Copenhagen Sample of the Danish Adoption Study of Schizophrenia

1981 • 251 citations

Macromolecules and Behavior

1972 • 246 citations

Factors affecting the action of narcotics

1978 • 243 citations

Effects of atropine, reserpine, 6-hydroxydopamine, and handling on seizure development in the rat

1973 • 240 citations

Cerebral Ventricular Size and Neuropsychological Impairment in Young Chronic Schizophrenics

1980 • 228 citations

Glutamate as transmitter of hippocampal perforant path

1977 • 227 citations

SCHIZOPHRENIA AND THE LIMBIC SYSTEM

1974 • 223 citations

Effects of differential environments on plasticity of dendrites of cortical pyramidal neurons in adult rats

1978 • 222 citations

Does the Engram of Kindling Model the Engram of Normal Long Term Memory?

1975 • 220 citations

Ventricular enlargement in schizophrenia: definition and prevalence

1982 • 215 citations

Kindling of the mesolimbic dopamine system

1978 • 210 citations

Effects of environmental enrichment and impoverishment on rat cerebral cortex

1972 • 208 citations

Monoamine Mechanisms in Chronic Schizophrenia: Post-Mortem Neurochemical Findings

1979 • 208 citations

Cerebrospinal Fluid Amine Metabolites in Acute Schizophrenia

1975 • 202 citations

ELECTRO-ACUPUNCTURE AND PAIN THRESHOLD

1973 • 201 citations

Coping and the Stress-Induced Potentiation of Stimulant Stereotypy in the Rat

1983 • 181 citations

Schizophrenia as a Brain Disease

1983 • 179 citations

Subnormal CSF levels of neurotensin in a subgroup of schizophrenic patients: normalization after neuroleptic treatment

1982 • 176 citations

Characteristics and function of opioids

1979 • 174 citations

Dopamine receptors, neuroleptics, and schizophrenia

1981 • 171 citations

Calcium-induced long-term potentiation in the hippocampus

1982 • 170 citations

Structural changes in the aging brain

1975 • 170 citations

Effects of complex or isolated environments on cortical dendrites of middle-aged rats

1983 • 169 citations

Structural Brain Deficits in Schizophrenia

1981 • 167 citations

CSF monoamine metabolites in depression and schizophrenia

1980 • 165 citations

Reduced cholecystokinin-like and somatostatin-like immunoreactivity in limbic lobe is associated with negative symptoms in schizophrenia

1983 • 164 citations

Progressive dendritic changes in the aging human limbic system

1976 • 158 citations

Endogenous opiods may mediate post-ictal behavioral depression in amygdaloid-kindled rats

1979 • 156 citations

Knowing, Thinking, and Believing

1976 • 154 citations

Perspectives in schizophrenia research

1980 • 153 citations

STIMULATION OF THE AMYGDALOID NUCLEUS IN A SCHIZOPHRENIC PATIENT

1955 • 149 citations

The Antagonism of Amphetamine-Induced Symptomatology by a Neuroleptic

1974 • 149 citations

Environmentally-induced Changes in the Brains of Elderly Rats

1973 • 149 citations

Computed Tomography in Schizophrenics and Normal Volunteers

1982 • 140 citations

Cerebral Ventricular Enlargement in Subtypes of Chronic Schizophrenia

1982 • 139 citations

NEURAL MECHANISMS INVOLVED IN A CAT'S ATTACK ON A RAT

1970 • 139 citations

Acceleration by stress of dopamine synthesis and metabolism in prefrontal cortex: Antagonism by diazepam

1982 • 137 citations

The temporal evolution of the distribution of dendritic spines in the visual cortex of normal and dark raised mice

1969 • 135 citations

Regional Cerebral Blood Flow in Schizophrenics

1983 • 135 citations

Lateralized effects of monocular training on dendritic branching in adult split-brain rats

1982 • 135 citations

The supplementary motor area in the cerebral cortex of man

1950 • 133 citations

Experimental amblyopia in monkeys. Further behavioral observations and clinical correlations.

1973 • 133 citations

The development of synapses in kitten visual cortex during visual deprivation

1975 • 133 citations

Environmental complexity modulates growth of granule cell dendrites in developing but not adult hippocampus of rats

1978 • 132 citations

Spontaneous recurrent seizure state induced by daily electric amygdaloid stimulation in Senegalese baboons ( Papio papio )

1976 • 132 citations

Parental Representations of Schizophrenics and their Association with Onset and Course of Schizophrenia

1982 • 131 citations

The effect of monocular deprivation on the synaptic contacts of the visual cortex

1969 • 130 citations

Quantitative study on dendrites and dendritic spines in Alzheimer's disease and senile dementia.

1975 • 129 citations

Chemical and Anatomical Plasticity of Brain: Replications and Extensions, 1970

1972 • 128 citations

Principles for Scoring Communication Defects and Deviances in Parents of Schizophrenics:

1966 • 126 citations

The Dopamine Hypothesis: An Overview of Studies With Schizophrenic Patients

1982 • 126 citations

Inhibition of calcium-dependent regulator-stimulated phosphodiesterase activity by neuroleptic drugs is unrelated to their clinical efficacy.

1979 • 125 citations

Cytomegalovirus Antibody in Cerebrospinal Fluid of Schizophrenic Patients Detected by Enzyme Immunoassay

1982 • 125 citations

Synaptic transmission is required for initiation of long-term potentiation

1978 • 123 citations

Generality of the Kindling Phenomenon: Some Clinical Implications

1975 • 121 citations

Progressive effects of cocaine on behavior and central amine metabolism in rhesus monkeys: relationship to kindling and psychosis.

1976 • 121 citations

Regional Cerebral Blood Flow in Schizophrenia

1982 • 117 citations

Human prolactin responses to neuroleptic drugs correlate with antischizophrenic potency

1977 • 116 citations

The Viral Hypothesis of Schizophrenia*

1976 • 116 citations

Endogenous opioid peptides: review of physiological, pharmacological and clinical aspects

1982 • 115 citations

Effects of high-frequency synaptic stimulation on glumate receptor binding studied with a modified in vitro hippocampal slice preparation

1982 • 115 citations

Differential effects of electrical stimulation and lesions of the hippocampus and adjacent regions upon attack behavior in cats

1968 • 115 citations

Recent Stressful Life Events and Episodes of Schizophrenia

1981 • 111 citations

Schizophrenia: Science and Practice

1979 • 109 citations

Development and Plasticity of the Brain: An Introduction

1978 • 105 citations

The effect of monocular deprivation on dendritic spines in visual cortex of young and adult albino rats: evidence for a sensitive period

1979 • 104 citations

Limbic epilepsy and the dyscontrol syndrome

1981 • 103 citations

DOPAMINE-RECEPTOR-STIMULATING AUTOANTIBODIES: A POSSIBLE CAUSE OF SCHIZOPHRENIA

1982 • 103 citations

SEQUENCE DIVERSITY STUDIES OF RAT BRAIN RNA: EFFECTS OF ENVIRONMENTAL COMPLEXITY ON RAT BRAIN RNA DIVERSITY

1978 • 101 citations

The effect of unilateral deprivation on visual centers in rats

1970 • 101 citations

A probable neuroleptic effect on platelet monoamine oxidase in chronic schizophrenic patients

1981 • 98 citations

5-Hydroxyindoleacetic acid (5 HIAA) and homovanillic acid (HVA) following probenecid in acute psychotic patients treated with phenothiazines

1973 • 98 citations

Increase in glutamate receptors following repetitive electrical stimulation in hippocampal slices

1980 • 97 citations

Development of visuomotor behavior in normal and dark-reared cats

1976 • 95 citations

The effect of acidic amino acid antagonists on synaptic transmission in the hippocampal formation in vitro

1979 • 95 citations

Environmental influences on brain and behavior of year‐old rats

1971 • 94 citations

The Syndrome of Schizophrenia: Unresolved Questions and Opportunities for Research

1980 • 94 citations

Chronic phenylethylamine stereotypy in rats: A new animal model for schizophrenia?

1977 • 94 citations

Changes in cortical dendritic branching subsequent to partial social isolation in stumptailed monkeys

1978 • 87 citations

Mechanisms Mediating the Production of Environmentally Induced Brain Changes

1981 • 87 citations

Schizophrenia and cerebral asymmetry detected by computed tomography

1982 • 87 citations

Cerebellar vermal atrophy in psychiatric patients.

1982 • 85 citations

Neural Plasticity in Visual Cortex of Adult Cats After Exposure to Visual Patterns

1975 • 83 citations

Mechanisms mediating the production of environmentally induced brain changes.

1975 • 83 citations

Limbic kindling and animal behavior--implications for human psychopathology associated with complex partial seizures.

1983 • 82 citations

Trifluoperazine inhibits hippocampal long-term potentiation and the phosphorylation of a 40,000 dalton protein

1980 • 81 citations

The Relationship between Function and Energy Metabolism: Its Use in the Localization of Functional Activity in the Nervous System

1981 • 80 citations

Behavioral and Epileptic Determinants of Predatory Attack Behavior in the Cat

1975 • 80 citations

The supplementary motor area in the cerebral cortex in man

1949 • 80 citations

Deep Temporal Stimulation in Man

1969 • 79 citations

The effects of vision and dark-rearing on the size and density of synapses in the lateral geniculate nucleus measured by electron microscopy

1969 • 79 citations

Modulation of long-term potentiation: Effects of adrenergic and neuroleptic drugs

1982 • 78 citations

Haloperidol-Induced Plasticity of Axon Terminals in Rat Substantia Nigra

1983 • 74 citations

Environmental Influences on the Neocortex in Later Life

1978 • 74 citations

Catecholamine modulation of enkephalin-induced electrophysiological responses in cerebral cortex.

1980 • 74 citations

Monoamine fluorescence histochemistry of human post mortem brain

1973 • 72 citations

Family Factors in Schizophrenic Relapse: A Replication

1982 • 70 citations

Further Studies on the Effects of Amygdaloid Stimulation and Ablation on Hypothalamically Elicited Attack Behavior in Cats

1967 • 70 citations

Neurochemical correlates of the kindling model of epilepsy

1982 • 69 citations

Visual acuity and visual responsiveness in dark-reared monkeys (Macaca nemestrina)

1976 • 67 citations

The hippocampus: Organizational patterns in health and senescence

1979 • 65 citations

A pharmacological study of changes in central nervous system receptor responsiveness after long-term dexamphetamine and apomorphine administration

1978 • 64 citations

Effect of synthetic substance P on monoaminergic mechanisms in brain

1976 • 64 citations

Prediction of early relapse after pimozide discontinuation by response to d-amphetamine during pimozide treatment.

1982 • 62 citations

Parent-Child Relationships and Psychopathological Disorder in the Child

1975 • 61 citations

Computed Tomography in Schizophrenics and Normal Volunteers

1982 • 60 citations

Effects of deprivation on the visual cortex of cat and monkey.

1978 • 60 citations

The hippocampus and its response to differential environments

1980 • 60 citations

Sensitization to amphetamine and stress may involve nucleus accumbens and medial frontal cortex

1979 • 59 citations

Monoamines and monoamine metabolites in brains from demented schizophrenics

1979 • 59 citations

Recurrent Spontaneous Seizure State Induced by Prefrontal Kindling in Senegalese Baboons, Papio Papio

1975 • 58 citations

Systems thinking in psychiatry: some theoretical and clinical implications

1983 • 54 citations

A Further Investigation into the Mechanisms Underlying the Kindling Phenomenon

1978 • 51 citations

Changes of axosomatic synapses in the visual cortex of monocularly deprived rats

1970 • 50 citations

The neural control of behavior

1971 • 49 citations

The biologic basis of schizophrenia

1966 • 48 citations

The Effects of Environmental Manipulation On The Morphology of The Neonate Rat Brain

1971 • 46 citations

The Biologic Basis of Schizophrenia.

1966 • 44 citations

An Holistic Developmental View of Neural and Psychological Processes: a Neurobiologic-Psychoanalytic Integration

1979 • 44 citations

Specificity of Synaptic Growth in Brain: Remodeling Induced by Kainic Acid Lesions

1979 • 44 citations

An Independent Analysis of the Copenhagen Sample of the Danish Adoption Study of Schizophrenia

1982 • 43 citations

Schizophrenic Deterioration

1983 • 43 citations

Effect of atropine sulfate on amygdaloid kindling in the rat

1979 • 42 citations

Brain density deficits in chronic schizophrenia

1980 • 42 citations

Dendritic length in aged rats' occipital cortex: An environmentally induced response

1981 • 42 citations

Electroencephalographic studies in isolation-raised monkeys with behavioral impairment.

1972 • 42 citations

Increased length of terminal dendritic segments in old adult rats' somatosensory cortex: An environmentally induced response

1982 • 41 citations

Kindling as a model for limbic epilepsy

1981 • 41 citations

Brain monoamine changes in chronic paranoid schizophrenia and their possible relation to increased dopamine receptor sensitivity.

1980 • 41 citations

The schizophrenia syndrome. Examples of biological tools for subclassification.

1981 • 41 citations

Asymmetries in the densities of white and gray matter in the brains of schizophrenic patients

1983 • 40 citations

Immunocytochemical localization on neuropeptides in the fornix of rat, monkey and man

1983 • 39 citations

Levels of Schizophrenia

1982 • 39 citations

Do neurotrophic interactions control synapse formation in the adult rat brain?

1980 • 38 citations

Alpha-adrenergic receptor function in schizophrenia, affective disorders and some neurological diseases.

1980 • 37 citations

The Schizophrenia Syndrome

1981 • 37 citations

Anatomical Brain Changes Induced by Environment

1976 • 37 citations

Regional cerebral blood flow in schizophrenia: a preliminary report

1981 • 37 citations

Neuroleptic-induced decrease in platelet MAO activity of schizophrenic patients

1981 • 36 citations

Perceptual Development in Mammals

1976 • 35 citations

Biochemical and physiological studies of long-term synaptic plasticity.

1979 • 35 citations

Discovery of the mesocortical dopaminergic system: some pharmacological and functional characteristics.

1977 • 34 citations

Effect of neuroleptic drugs on platelet monoamine oxidase in psychiatric patients

1982 • 32 citations

Hallucinations Produced by Electrical Stimulation of the Temporal Lobes in Schizophrenic Patients

1964 • 30 citations

Behavioural, physiological, and anatomical consequences of monocular deprivation in the golden hamster (Mesocricetus auratus)

1982 • 29 citations

A quantitative Golgi study in the occipital cortex of the pyramidal dendritic topology of old adult rats from social or isolated environments

1982 • 29 citations

Distribution of glutamate in layers of the rabbit hippocampal fields CA1, CA3, and the dentate area

1979 • 29 citations

Towards an Ecology of Brain

1981 • 28 citations

Brain-specific proteins in the occipital cortex of rats housed in enriched and impoverished environments

1979 • 28 citations

Neuroplasticity in the Hippocampal Formation

1978 • 27 citations

Posttraining changes in excitability of the commissural path-CA1 pyramidal cell synapse in the hippocampus of mice

1981 • 25 citations

Lack of Behavioral Supersensitivity to d-Amphetamine After Pimozide Withdrawal

1980 • 24 citations

Low platelet MAO activity in chronic schizophrenics: A long-term effect of neuroleptic treatment?

1983 • 24 citations

Long-lasting behavioral and dendritic spine deficits in the monocularly deprived albino rat

1980 • 23 citations

Response threshold to levodopa in psychiatric patients.

1973 • 22 citations

NEUROTENSIN-NEUROLEPTIC SIMILARITIES: AN EXAMPLE OF PEPTIDE-CATECHOLAMINE INTERACTIONS

1979 • 21 citations

Behavioral recovery from binocular deprivation in the cat

1982 • 19 citations

Synaptic plasticity

1979 • 19 citations

The neural basis of prolonged suppression of predatory attack. I. Naturally occurring physiological differences in the limbic systems of killer and non-killer cats

1975 • 18 citations

SOMATOSENSORY RESTRICTION AND BEHAVIORAL DEVELOPMENT IN STUMPTAIL MONKEYS

1977 • 17 citations

Amygdaloid kindling procedure reduces severity of morphine withdrawal syndrome in rats

1980 • 17 citations

Neuronal Mechanisms in Experience Dependent Modification of Visual Cortex Function

1979 • 16 citations

Can Mother-infant Interaction Produce Vulnerability to Schizophrenia?

1981 • 16 citations

Effects of long-term neuroleptic use on brain density

1981 • 16 citations

Plastic and degenerative changes in visual centers.

1974 • 15 citations

Contemporary theories of schizophrenia : review and synthesis

1979 • 13 citations

Effect of Chlorpromazine treatment on Monoamine Oxidase activity in platelets isolated by the Corash method

1981 • 13 citations

Relationship between estimated premorbid adjustment and CSF homovanillic acid and 5-hydroxyindoleacetic acid levels

1981 • 12 citations

Changes in Neuronal Activity in the Neostriatum and Reticular Formation Following Acute or Long-Term Amphetamine Administration

1977 • 12 citations

Families Today: A Research Sampler on Families and Children.

1981 • 12 citations

Post-mortem fluorescence histochemistry of monoamine neuron systems in the human brain: A new approach in the search for a neuropathology of schizophrenia

1974 • 11 citations

Schizophrenic deterioration. 2.

1983 • 9 citations

Functional hyperinnervation of cerebral cortex by noradrenergic neurons results from fetal lesions: parallels with schizophrenia.

1980 • 8 citations

Reduction of dopaminergic supersensitivity by a single dose of amphetamine

1980 • 8 citations

MONOAMINE NEURON SYSTEMS IN THE NORMAL AND SCHIZOPHRENIC HUMAN BRAIN: FLUORESCENCE HISTOCHEMISTRY OF FETAL, NEUROSURGICAL AND POST MORTEM MATERIAL**Supported by the Swedish Medical Research Council (04X-3185), “Magnus Bergvalls Stiftelse” and “Karolinska Institutets Forskningsfonder”. The post mortem brains were obtained through the kind help of Dr. L. Wetterberg, Psychiatric Research Center, Ulleråker Hospital, Uppsala.

1973 • 6 citations

On the question of neuronal plasticity in the mature visual cortex.

1978 • 4 citations

Perspectives in Schizophrenia Research

1982 • 1 citations